AIM2 - absent in melanoma 2 Gene

中文名称：黑色素瘤中缺失 2

种属: Homo sapiens

同用名: PYHIN4

基因 ID: 9447 | 基因类型: protein coding

关于 AIM2

Cytogenetic location: 1q23.1-q23.2 Genomic coordinates (GRCh38): 1:159,055,051-159,147,132 (from NCBI)

This gene has 8 transcripts (splice variants), 48 orthologues and 3 paralogues. Biased expression in lymph node (RPKM 9.4), appendix (RPKM 5.0) and 5 other tissues.

功能概要

AIM2 是 IFI20X /IFI16 系列的成员。它在致瘤性逆转中起着推定的作用，并可能控制细胞增殖。干扰素-γ 诱导 AIM2 的表达。[RefSeq 提供，2008 年 7 月]

AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. [provided by RefSeq, Jul 2008]

AIM2 基因产物(2)

mRNA	Protein	Name
NM_001348247.2	NP_001335176.1	interferon-inducible protein AIM2 isoform 2
NM_004833.3	NP_004824.1	interferon-inducible protein AIM2 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cysteine-type endopeptidase activator activity	IDA IDA: 通过直接分析推断	19158679	GOA
enables double-stranded DNA binding	IDA IDA: 通过直接分析推断	19158675	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	19158676	GOA
enables pattern recognition receptor activity	IDA IDA: 通过直接分析推断	26197926	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	19158675	GOA
enables signaling adaptor activity	IDA IDA: 通过直接分析推断	23530044	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in AIM2 inflammasome complex assembly	IDA IDA: 通过直接分析推断	19158676	GOA
involved in activation of innate immune response	IDA IDA: 通过直接分析推断	19158675	GOA
acts upstream of or within cellular response to xenobiotic stimulus	IDA IDA: 通过直接分析推断	19158679	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IDA IDA: 通过直接分析推断	16432157	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: 通过直接分析推断	19158675	GOA
involved in positive regulation of cysteine-type endopeptidase activity	IDA IDA: 通过直接分析推断	19158676	GOA
involved in positive regulation of interleukin-1 beta production	IDA IDA: 通过直接分析推断	19158675	GOA
involved in pyroptosome complex assembly	IDA IDA: 通过直接分析推断	19158676	GOA
involved in pyroptotic inflammatory response	IDA IDA: 通过直接分析推断	19158675	GOA
involved in tumor necrosis factor-mediated signaling pathway	IDA IDA: 通过直接分析推断	16432157	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of AIM2 inflammasome complex	IDA IDA: 通过直接分析推断	19158676	GOA
part of AIM2 inflammasome complex	IPI IPI: 通过物理相互作用推断	24630722	GOA
is active in cytoplasm	IDA IDA: 通过直接分析推断	8454910	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	19158676	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AIM2 蛋白结构

PYRIN

HIN

0
100
200
300
343 a.a.

蛋白主名

其他名称

interferon-inducible protein AIM2

重组 AIM2 蛋白

目录号	产品名	蛋白编号	纯度
HY-P72816	AIM2 Protein, Human (sf9, GST)	O14862/NP_004824.1 (M1-T343)	≥95%

关联疾病

疾病名称

别名

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Brucellosis

Mediterranean Fever	Malta Fever
Undulant Fever	Gibraltar Fever
Bang'S Disease	Maltese Fever
Cyprus Fever	Rock Fever
Brucellosis Infection	Brucella Infection

Tularemia

Francisella Tularensis Infection	Deerfly Fever
Lemming Fever	Ohara Disease
Pahvant Valley Plague	Rabbit Fever
Yatobyo

Renal Infectious Disease

Cinca Syndrome

CINCA	Nomid
Cryopyrin-Associated Periodic Syndrome 3	Chronic Neurologic Cutaneous And Articular Syndrome
Multisystem Inflammatory Disease, Neonatal-Onset	Caps3
Chronic Infantile Neurological Cutaneous Articular Syndrome	Infantile-Onset Multisystem Inflammatory Disease
Iomid Syndrome	Neonatal-Onset Multisystem Inflammatory Disease
Nomid Syndrome	Prieur-Griscelli Syndrome
Neonatal Onset Multisystem Inflammatory Disease	Chronic Infantile Neurological, Cutaneous And Articular Syndrome
Iomid	Infantile Onset Multisystem Inflammatory Disease
Prieur Griscelli Syndrome	Chronic Infantile Neurological Cutaneous And Articular Syndrome
Chronic, Infantile, Neurological, Cutaneous, Articular Syndrome	Chronic Infantile Neurologic Cutaneous And Articular Syndrome
Chronic Infantile Neurological, Cutaneous, And Articular Syndrome	Cryopyrin-Associated Periodic Syndromes

Muckle-Wells Syndrome

MWS	Urticaria-Deafness-Amyloidosis Syndrome
Uda Syndrome	Neutrophilic Urticaria
Urticaria, Deafness And Amyloidosis	Cryopyrin-Associated Periodic Syndrome 2
Caps2	Muckle Wells Syndrome
Urticaria-Deafness-Amyloidosis	Cryopyrin-Associated Periodic Syndromes

Pneumonic Tularemia

Pulmonary Tularemia	Bronchopneumonic Tularemia
Pneumonic Tularaemia

Familial Cold Autoinflammatory Syndrome

Familial Cold Urticaria	Fcas
Familial Polymorphous Cold Eruption	Fcu
Cold Hypersensitivity

Colon Sarcoma

Colonic Sarcoma

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Aicardi-Goutières Syndrome	Encephalopathy With Basal Ganglia Calcification
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Chilblain Lupus 1

Chilblain Lupus	CHBL1
Chilblain Lupus Erythematosus	Chle
Hutchinson Lupus	Chilblain Lupus, Type 1

Salmonellosis

Salmonella Infections

Salmonella Infection

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-N0822	Shikonin	Inhibitor	99.80%	否
HY-144226	NLRP3/AIM2-IN-3	Inhibitor	98.00%	否
HY-150751	ODN TTAGGG	Antagonist	99.87%	否
HY-152670	JC2-11	Inhibitor	98.02%	否
HY-144223	NLRP3/AIM2-IN-2	Inhibitor	99.88%	否
HY-150751C	ODN TTAGGG sodium	Antagonist	99.87%	否
HY-138646	Poly(deoxyadenylic-thymidylic) acid sodium	Activator	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	AIM2	RGD	RGD:1307283
Mus musculus	AIM2	MGD	MGI:2686159

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

AIM2 - absent in melanoma 2 Gene

关于 AIM2

功能概要

AIM2 基因产物(2)

AIM2 蛋白结构

重组 AIM2 蛋白

关联疾病

直系同源

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AIM2 - absent in melanoma 2 Gene

关于 AIM2

功能概要

AIM2 基因产物(2)

AIM2 蛋白结构

重组 AIM2 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z