VGLL4 - vestigial like family member 4 Gene

中文名称：退化样家族成员 4

种属: Homo sapiens

同用名: VGL-4

基因 ID: 9686 | 基因类型: protein coding

关于 VGLL4

Cytogenetic location: 3p25.3-p25.2 Genomic coordinates (GRCh38): 3:11,556,067-11,721,815 (from NCBI)

This gene has 18 transcripts (splice variants) and 267 orthologues. Ubiquitous expression in ovary (RPKM 26.1), thyroid (RPKM 18.5) and 25 other tissues.

功能概要

预测启用转录辅激活因子结合活性。参与 Wnt 信号通路的负调控；细胞生长的负调节；和河马信号的负调节。预测位于核内。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable transcription coactivator binding activity. Involved in negative regulation of Wnt signaling pathway; negative regulation of cell growth; and negative regulation of hippo signaling. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

VGLL4 基因产物(6)

mRNA	Protein	Name
NM_001128219.3	NP_001121691.1	transcription cofactor vestigial-like protein 4 isoform a
NM_001128220.3	NP_001121692.1	transcription cofactor vestigial-like protein 4 isoform c
NM_001128221.3	NP_001121693.1	transcription cofactor vestigial-like protein 4 isoform d
NM_001284390.2	NP_001271319.1	transcription cofactor vestigial-like protein 4 isoform e
NM_001284391.1	NP_001271320.1	transcription cofactor vestigial-like protein 4 isoform f
NM_014667.4	NP_055482.2	transcription cofactor vestigial-like protein 4 isoform b

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	21044950	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of Wnt signaling pathway	IDA IDA: 通过直接分析推断	28051067	GOA
involved in negative regulation of cell growth	IDA IDA: 通过直接分析推断	28051067	GOA
involved in negative regulation of hippo signaling	IDA IDA: 通过直接分析推断	28051067	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

VGLL4 蛋白结构

VGLL4

0
100
200
290 a.a.

蛋白主名

其他名称

transcription cofactor vestigial-like protein 4

Vestigial-like 4

VGLL4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	VGLL4	Q14135	TEAD3	Homo sapiens	Q99594	Validated Y2H	32296183
种属内	VGLL4	Q14135	TEAD3	Homo sapiens	Q99594	Anti Tag CoIP	33961781
种属内	VGLL4	Q14135	TEAD3	Homo sapiens	Q99594	Y2H Prey Pooling	32296183
种属内	VGLL4	Q14135	TEAD3	Homo sapiens	Q99594	Y2H Array	32296183
种属内	VGLL4	Q14135	TEAD4	Homo sapiens	Q15561	BLI	24525233
种属内	VGLL4	Q14135	TEAD4	Homo sapiens	Q15561	Anti Tag CoIP	33961781
种属内	VGLL4	Q14135	TERF2IP	Homo sapiens	Q9NYB0	Pull Down	21044950
种属内	VGLL4	Q14135	TERF2IP	Homo sapiens	Q9NYB0	BiFC	21044950
种属内	VGLL4	Q14135	TEAD2	Homo sapiens	Q15562-2	Validated Y2H	32296183
种属内	VGLL4	Q14135	TEAD2	Homo sapiens	Q15562-2	Y2H Array	32296183
种属内	VGLL4	Q14135	TEAD2	Homo sapiens	Q15562-2	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Sveinsson Chorioretinal Atrophy

SCRA	Atrophia Areata
Helicoid Peripapillary Chorioretinal Degeneration	Hpcd
Aa	Peripapillary Chorioretinal Degeneration, Icelandic Type
Helicoidal Peripapillary Chorioretinal Degeneration	Atrophy, Chorioretinal, Sveinsson

Cerebral Cavernous Malformations

Cerebral Cavernous Malformation	Cavernous Malformations Of Cns And Retina
Cerebral Cavernous Malformation 1	Cavernous Angiomatous Malformations
Cerebral Capillary Malformations	CCM
Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations	Familial Cavernous Angioma
Cavernous Angioma	Familial Cerebral Cavernous Malformation
Cerebral Cavernous Malformations 1	Cavernous Angioma, Familial
Cam	Cerebral Cavernous Malformations-1
Cavernoma	Central Nervous System Cavernous Hemangioma
Cerebral Cavernous Hemangioma	Familial Cavernous Hemangioma
Familial Cavernous Malformation	Familial Cerebral Cavernous Angioma
Intracerebral Cavernous Hemangioma	CCM1
Cavernous Hemangioma Of The Brain	Cerebral Cavernoma
Cerebral Cavernous Malformations, Type 1	Hemangioma, Cavernous, Central Nervous System
Hemangioma, Cavernous	Angioma, Cavernous

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-137479	TEAD-IN-1	Inhibitor	/	否
HY-RS15647	VGLL4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	VGLL4	VGNC	VGNC:36793
Canis familiaris	VGLL4	VGNC	VGNC:48260
Macaca mulatta	VGLL4	VGNC	VGNC:79755
Rattus norvegicus	VGLL4	RGD	RGD:1311653
Mus musculus	VGLL4	MGD	MGI:2652840
Felis catus	VGLL4	VGNC	VGNC:80753

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

VGLL4 - vestigial like family member 4 Gene

关于 VGLL4

功能概要

VGLL4 基因产物(6)

VGLL4 蛋白结构

VGLL4 蛋白互作信息

关联疾病

直系同源

热门区域

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VGLL4 - vestigial like family member 4 Gene

关于 VGLL4

功能概要

VGLL4 基因产物(6)

VGLL4 蛋白结构

VGLL4 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z