1. Gene
  2. CD69 - CD69 molecule Gene

CD69 - CD69 molecule Gene

中文名称:CD69 分子

种属: Homo sapiens

同用名: AIM; EA1; MLR-3; CLEC2C; GP32/28; BL-AC/P26

基因 ID: 969 | 基因类型: protein coding

关于 CD69

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:9,752,486-9,760,901 (from NCBI)

This gene has 4 transcripts (splice variants), 221 orthologues and 23 paralogues. Biased expression in bone marrow (RPKM 55.9), lymph node (RPKM 41.3) and 13 other tissues.

功能概要

该基因编码 II 型跨膜受体的钙依赖性凝集素超家族的成员。编码蛋白的表达在 T 淋巴细胞激活后被诱导,并可能在增殖中发挥作用。此外,该蛋白质还可以在自然杀伤细胞和血小板中传递信号。[RefSeq 提供,2011 年 8 月]

This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. [provided by RefSeq, Aug 2011]

CD69 基因产物(1)

mRNA Protein Name
NM_001781.2 NP_001772.1 early activation antigen CD69
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IDA
IDA: 通过直接分析推断
11101293 GOA
enables molecular sequestering activity IDA
IDA: 通过直接分析推断
37039481 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16525420 GOA
enables transmembrane signaling receptor activity IDA
IDA: 通过直接分析推断
24752896 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of T cell migration IDA
IDA: 通过直接分析推断
37039481 GOA
involved in negative regulation of T-helper 17 cell lineage commitment IDA
IDA: 通过直接分析推断
24752896 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in plasma membrane IDA
IDA: 通过直接分析推断
37039481 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
11101293 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CD69 蛋白结构

Lectin_C

Lectin_C: Lectin C-type domain (103 - 196)

  • 0
  • 100
  • 199 a.a.
蛋白主名 其他名称

early activation antigen CD69

C-type lectin domain family 2, member C

重组 CD69 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72713 CD69 Protein, Human (HEK293, His) Q07108 (G64-K199) ≥95%

关联疾病

疾病名称 别名
Coccidioidomycosis

Valley Fever

Primary Extrapulmonary Coccidioidomycosis

Coccidioides Immitis Infection

Coccidiosis

Coccidioides Infection

Coccidioidomycosis, Unspecified

San Joaquin Fever

California Disease

Desert Fever

Desert Rheumatism

San Joaquin Valley Fever

Enteric Coccidiosis

Primary Pulmonary Coccidioidomycosis

Acute Coccidioidomycosis

Posadas Wernicke Disease

Eosinophilic Pneumonia

Pneumonia, Eosinophilic

Pulmonary Eosinophilia

Asthmatic Pulmonary Eosinophilia

Pneumonia Eosinophilic

Simple Pulmonary Eosinophilia

Eosinophilic Asthma

Milk Allergy

Milk Allergic Reaction

Milk Hypersensitivity

Allergy Milk

Intermediate Uveitis

Uveitis, Intermediate

Chronic Cyclitis

Peripheral Uveoretinitis

Iu

Uveitis Intermediate

Allergic Asthma

Atopic Asthma

Extrinsic Asthma

Extrinsic Asthma With Acute Exacerbation

Extrinsic Asthma With Status Asthmaticus

Asthma Allergic

Atopic Asthma, Susceptibility To

Ige-Mediated Allergic Asthma

Allergen-Induced Asthma

Allergic Asthma Without Stated Status Asthmaticus

Predominantly Allergic Asthma Without Stated Status Asthmaticus

Predominantly Allergic Asthma

Allergic Asthma Nos

Catarrh With Asthma

Allergic Bronchitis Nos

Extrinsic Allergic Asthma

Predominantly Allergic Asthma With Stated Status Asthmaticus

Peritonitis

Retractile Mesenteritis

Sclerosing Mesenteritis

Acute Generalized Peritonitis

Primary Bacterial Peritonitis

Idiopathic Sclerosing Mesenteritis

Mesenteric Panniculitis

Peritoneal Retractile Mesenteritis

Liposclerotic Mesenteritis

Mesenteric Fibromatosis

Mesenteric Lipodystrophy

Mesenteric Lipogranuloma

Fibromatosis, Abdominal

Peritoneum Inflammation

Peritonitis Of Undetermined Cause

Peritonitis Of Unspecified Cause

Pelviperitonitis

Pelvic Peritonitis, Nos

Generalised Peritonitis Nos

Abdominal Peritonitis

Acute Idiopathic Peritonitis

Acute Lesser Sac Peritonitis

Acute Peritoneal Inflammation

Diffuse Peritonitis

Peritoneal Inflammation

Acute Primary Peritonitis

Pneumococcal Peritonitis

Uveitis
Synovitis
Autoimmune Disease

Autoimmune Diseases

Autoimmune Hypersensitivity Disease

Hypersensitivity Reaction Type Ii Disease

Type Ii Hypersensitivity Reaction Disease

Human Immunodeficiency Virus Infectious Disease

Hiv Infections

Common Variable Immunodeficiency

Cvid

Common Variable Agammaglobulinemia

Common Variable Immune Deficiency

Acquired Hypogammaglobulinemia

Hypogamma-Globulinemia, Acquired

Idiopathic Immunoglobulin Deficiency

Primary Antibody Deficiency

Primary Hypogammaglobulinemia

Acquired Agammaglobulinemia

Sporadic Hypogammaglobulinemia

Common Variable Hypogamma-Globulinemia

Immunoglobulin Deficiency, Late-Onset

Common Variable Hypogammaglobulinemia

Immunodeficiency, Common Variable

Leishmaniasis

Post-Kala-Azar Dermal Leishmaniasis

Post Kala-Azar Dermal Leishmaniasis

Post-Kala-Azar Dermal Infectious Disease By Leishmaniasis

Cutaneous Leishmaniasis

Kala-Azar

Visceral Leishmaniasis

Leishmaniasis, Cutaneous

Leishmaniasis, Visceral

Leishmania

Leishmania Infection

Leishmaniosis

Hypereosinophilic Syndrome

Eosinophilia

HES

Eosinophilic Leukocytosis

Hypereosinophilic Syndrome, Idiopathic

Idiopathic Hypereosinophilic Syndrome

Disseminated Eosinophilic Collagen Disease

Eosinophilic Disorder

Disorders With Increased Eosinophil Counts

Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]

Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis

Mycobacterium Tuberculosis 1

Tuberculosis

Tuberculoma

Tuberculosis, Susceptibility To

Mycobacterium Tuberculosis, Susceptibility To, 1

Mtbs1

TB

Allergic Disease

Hypersensitivity

Allergic Hypersensitivity Disease

Allergic Condition

Allergic Reaction

Allergic Disposition

Immune Deficiency Disease

Immunodeficiency

Primary Immunodeficiency

Primary Immunodeficiency Disease

Immunologic Deficiency Syndromes

Hypoimmunity

Immune Deficiency Disorder

Immunodeficiency Syndrome

Immune Disorder

Primary Immune Deficiency Disorder

Immune System Diseases

Human Immunodeficiency Virus Infection

Hiv - [Human Immunodeficiency Virus Infection]

Hiv Positive Nos

Hiv Disease

Acquired Immune Deficiency Syndrome-Related Complex

Aids-Like Syndrome

Aids-Related Complex Nos

Arc - [Aids-Related Complex]

Immunodeficiency Due To Human Immunodeficiency Virus Infection

Unspecified Human Immunodeficiency Virus Disease

Hiv Disease Nos

Human Immunodeficiency Virus Positive Nos

Hiv Nos

Deficiency Of Complement Initial Pathway

Deficiency Of Complement Terminal Pathway

Cfdd - [Complement Factor D Deficiency]

Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency

Nonfamilial Hypogammaglobulinaemia

Common Variable Immune Deficiency

Nonfamilial Agammaglobulinaemia

Common Variable Agammaglobulinaemia

Agammaglobulinaemia Nos

Agammaglobulinaemia Antibody Deficiency Syndrome

Hypogammaglobulinaemia Antibody Deficiency Syndrome

Acquired Agammaglobulinaemia Nos

Hypogammaglobulinaemia Nos

Hyper Igm

Multiple Sclerosis

MS

Multiple Sclerosis, Susceptibility To

Disseminated Sclerosis

Multiple Sclerosis, Disease Progression, Modifier Of

Insular Sclerosis

Multiple Sclerosis Modifier Of Disease Progression

Multiple Sclerosis, Susceptibility To 1

Multiple Sclerosis, Susceptibility To, 1

Multiple Sclerosis 1

Generalized Multiple Sclerosis

Multiple Sclerosis Variant

Multiple Sclerosis Susceptibility To

Cerebrospinal Sclerosis

Generalised Multiple Sclerosis

Ms - [Multiple Sclerosis]

Disseminated Cerebrospinal Sclerosis

Disseminated Multiple Sclerosis

Disseminated Nervous System Myelosclerosis

Multiple Cerebrospinal Sclerosis

Multiple Combined Sclerosis

Multiple Sclerosis Generalised

Disseminated Brain Sclerosis

Disseminated Spinal Sclerosis

Insular Brain Sclerosis

Miliary Brain Sclerosis

Multiple Combined Sclerosis Of Spinal Cord

Multiple Ascending Sclerosis

Multiple Brain Sclerosis

Multiple Sclerosis Of Brain Stem

Multiple Sclerosis Of The Brain Stem

Multiple Sclerosis Of Cord

Sclérose En Plaques

Plaque Sclerosis

Multiple Sclerosis Of The Spinal Cord

Psoriasis
Sarcoidosis 1

Sarcoidosis

Boeck Sarcoid

Besnier-Boeck-Schaumann Disease

SS1

Sarcoidosis, Susceptibility To, 1

Lymphogranulomatosis

Hodgkin Disease

Boeck'S Disease

Boeck'S Sarcoid

Schaumann'S Disease Or Syndrome

Hutchinson-Boeck Disease Or Syndrome

Dermatitis, Atopic

Atopic Dermatitis

Atopic Eczema

Dermatitis, Atopic, Susceptibility To, 1

Atod

Eczema, Atopic

Dermatitis, Atopic 1

Allergic Dermatitis

Atopic Neurodermatitis

Besnier'S Prurigo

Dermatitis, Atopic, 1

Dermatitis Atopic

Eczema

Besnier Prurigo

Carbapenem Allergy
Bacterial Infectious Disease

Bacterial Infections

Bacterial Infection Nos

Disease Caused By Bacteria

Bacterial Disease Or Disorder

Primary Bacterial Infectious Disease
Co-Trimoxazole Allergy

Bactrim Allergy

Cotrimoxazol Allergy

Tmp/Smx Allergy

Trimethoprim/Sulfamethoxazole Allergy

Myelodysplastic Syndrome

Myelodysplastic Syndromes

Myelodysplasia

MDS

Myelodysplastic Syndrome Included

Myelodysplastic Syndrome, Susceptibility To, Included

Myelodysplastic Syndrome, Somatic

Myelodysplastic Syndrome, Susceptibility To

Celiac Disease 1

Celiac Disease

Coeliac Disease

Celiac Sprue

Celiac Disease, Susceptibility To

Gluten-Sensitive Enteropathy

Nontropical Sprue

Sprue

CELIAC1

Celiac Disease, Susceptibility To, 1

Celiac Sprue 1

Celiac Sprue, Susceptibility To, 1

Gluten-Sensitive Enteropathy 1

Gluten-Sensitive Enteropathy, Susceptibility To, 1

Idiopathic Steatorrhea

Cœliac Disease

Gluten Intolerance

Gluten-Induced Enteropathy

Gluten Enteropathy

Celiac Disease, Susceptibility To, Type 1

Childhood Celiac Disease

Coeliac Rickets

Gee Disease

Gee-Herter Disease

Heubner-Herter Disease

Idiopathic Steatorrhoea

Thaysen'S Disease

Herter Gee Syndrome

Skin Disease

Skin Diseases

Genodermatosis

Abnormality Of The Skin

Skin Diseases, Genetic

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders

Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta CD69 VGNC VGNC:70776
Mus musculus CD69 MGD MGI:88343
Felis catus CD69 VGNC VGNC:83519
Rattus norvegicus CD69 RGD RGD:61318
Canis familiaris CD69 VGNC VGNC:38968
Bos taurus CD69 VGNC VGNC:27043
Macaca fascicularis CD69 NCBI NCBI:102141561
Others CD69 NCBI