2. Gene
  3. Wwtr1 - WW domain containing transcription regulator 1 Gene

Wwtr1 - WW domain containing transcription regulator 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Taz; 2310058J06Rik; 2610021I22Rik

基因 ID: 97064 | 基因类型: protein coding

关于 Wwtr1

功能概要

This gene encodes a binding protein of the 14-3-3 family of proteins that regulate cell cycle progression, differentiation and Apoptosis. The encoded protein is a transcriptional co-activator that binds to the PPXY motif present on transcription factors. The gene product contains a WW domain and, in the C-terminus, a conserved PDZ-binding motif. This gene is distinct from the gene encoding tafazzin. Both genes share the gene symbol Taz. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]

Wwtr1 基因产物(2)

mRNA Protein Name
NM_001168281.1 NP_001161753.1 WW domain-containing transcription regulator protein 1 isoform 1
NM_133784.3 NP_598545.2 WW domain-containing transcription regulator protein 1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11118213 MGI
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
16332960 MGI
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
16332960 MGI
enables transcription corepressor activity IGI
IGI: 通过遗传相互作用推断
16099986 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
17636028 MGI
acts upstream of or within cilium assembly IMP
IMP: 通过突变表型推断
17251353 MGI
acts upstream of or within glomerulus development IMP
IMP: 通过突变表型推断
18172001 MGI
involved in heart process IMP
IMP: 通过突变表型推断
23918388 MGI
acts upstream of or within kidney morphogenesis IMP
IMP: 通过突变表型推断
17636028 MGI
acts upstream of or within mesenchymal cell differentiation IMP
IMP: 通过突变表型推断
17636028 MGI
acts upstream of or within multicellular organism growth IMP
IMP: 通过突变表型推断
17636028 MGI
acts upstream of or within negative regulation of fat cell differentiation IGI
IGI: 通过遗传相互作用推断
16099986 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
16099986 MGI
acts upstream of or within osteoblast differentiation IGI
IGI: 通过遗传相互作用推断
16099986 MGI
acts upstream of or within osteoblast differentiation IMP
IMP: 通过突变表型推断
16099986 MGI
involved in positive regulation of protein localization to nucleus IMP
IMP: 通过突变表型推断
21145499 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
14970209 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
14970209 MGI
acts upstream of or within protein ubiquitination IDA
IDA: 通过直接分析推断
17636028 MGI
involved in protein ubiquitination IMP
IMP: 通过突变表型推断
21474562 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
14970209 MGI
acts upstream of or within regulation of canonical Wnt signaling pathway IGI
IGI: 通过遗传相互作用推断
23974041 MGI
acts upstream of or within regulation of metanephric nephron tubule epithelial cell differentiation IGI
IGI: 通过遗传相互作用推断
23974041 MGI
involved in tissue homeostasis IMP
IMP: 通过突变表型推断
23918388 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
11118213 MGI
located in nucleus IDA
IDA: 通过直接分析推断
11118213 MGI
part of transcription regulator complex IDA
IDA: 通过直接分析推断
14970209 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

WW domain-containing transcription regulator protein 1

transcriptional coactivator with PDZ-binding motif

Wwtr1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Wwtr1 Q9EPK5 CCAR1 Homo sapiens Q8IX12
Anti Tag CoIP
20594350
种属间
Wwtr1 Q9EPK5 CCAR1 Homo sapiens Q8IX12
IF
20594350
种属间
Wwtr1 Q9EPK5 CTNNB1 Homo sapiens P35222
Anti Tag CoIP
23245942
种属间
Wwtr1 Q9EPK5 TJP1 Homo sapiens Q07157
Pull Down
20850437
种属间
Wwtr1 Q9EPK5 Nkx2-1 Rattus norvegicus P23441
Pull Down
14970209
种属间
Wwtr1 Q9EPK5 TJP2 Canis familiaris Q95168
Pull Down
20850437
种属间
Wwtr1 Q9EPK5 TJP2 Canis familiaris Q95168
IF
20850437
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS16236 Wwtr1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS15862 WWTR1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Wwtr1 NCBI NCBI:25937
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z