ARHGEF11 - Rho guanine nucleotide exchange factor 11 Gene

中文名称：Rho 鸟嘌呤核苷酸交换因子 11

种属: Homo sapiens

同用名: GTRAP48; PDZ-RHOGEF

关于 ARHGEF11

功能概要

Rho GTP 酶在许多细胞过程中起着重要作用，这些过程由通过 G 蛋白偶联受体起作用的细胞外刺激物启动。编码的蛋白质可能与 G 蛋白形成复合物并刺激 Rho 依赖性信号。大鼠中的一种类似蛋白质与谷氨酸转运蛋白 EAAT4 相互作用并调节其谷氨酸转运活性。大鼠蛋白的表达诱导肌动蛋白细胞骨架的重组，其过度表达诱导膜褶皱和丝状伪足的形成。已经描述了编码不同亚型的两种替代转录本。[RefSeq 提供，2008 年 7 月]

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin Cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]