2. Gene
  3. TOX4 - TOX high mobility group box family member 4 Gene

TOX4 - TOX high mobility group box family member 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：TOX 高机动性组盒家族成员 4

种属: Homo sapiens

同用名: LCP1; MIG7; C14orf92; KIAA0737

基因 ID: 9878 | 基因类型: protein coding

关于 TOX4

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:21,477,195-21,499,170 (from NCBI)

This gene has 14 transcripts (splice variants), 278 orthologues and 20 paralogues.

功能概要

预测启用染色质 DNA 结合活性。预计参与 RNA 聚合酶 II 的转录调控。位于染色质中。 PTW/PP1 磷酸酶复合物的一部分。与染色体、端粒区域共定位。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable chromatin DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in chromatin. Part of PTW/PP1 Phosphatase complex. Colocalizes with chromosome, telomeric region. [provided by Alliance of Genome Resources, Apr 2022]

TOX4 基因产物(2)

mRNA Protein Name
NM_001303523.2 NP_001290452.1 TOX high mobility group box family member 4 isoform 2
NM_014828.4 NP_055643.1 TOX high mobility group box family member 4 isoform 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16713569 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of PTW/PP1 phosphatase complex IDA
IDA: 通过直接分析推断
20516061 GOA
located in chromatin IDA
IDA: 通过直接分析推断
20516061 GOA
colocalizes with chromosome, telomeric region IDA
IDA: 通过直接分析推断
24270157 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TOX4 蛋白结构

HMG_box

HMG_box: HMG (high mobility group) box (200 - 268)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 598 a.a.
蛋白主名 其他名称

TOX high mobility group box family member 4

epidermal Langerhans cell protein LCP1

TOX4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TOX4 O94842 MYL7 Homo sapiens Q01449
Y2H Array
25416956
Intra TOX4 O94842 MYL7 Homo sapiens Q01449
Validated Y2H
25416956
Intra TOX4 O94842 FNDC3B Homo sapiens Q53EP0-3
Validated Y2H
32296183
Intra TOX4 O94842 FNDC3B Homo sapiens Q53EP0-3
Y2H Array
25416956
Intra TOX4 O94842 FNDC3B Homo sapiens Q53EP0-3
Validated Y2H
25416956
Intra TOX4 O94842 BANP Homo sapiens Q8N9N5-2
Validated Y2H
32296183
Intra TOX4 O94842 QRICH1 Homo sapiens Q2TAL8
Validated Y2H
32296183
Intra TOX4 O94842 TBX6 Homo sapiens O95947
Validated Y2H
32296183
Intra TOX4 O94842 BANP Homo sapiens Q8N9N5
Y2H Array
25416956
Intra TOX4 O94842 ZMYND19 Homo sapiens Q96E35
Y2H Prey Pooling
25416956
Intra TOX4 O94842 ZMYND19 Homo sapiens Q96E35
Y2H Array
25416956
Intra TOX4 O94842 ZMYND19 Homo sapiens Q96E35
Validated Y2H
25416956
Intra TOX4 O94842 ZMYND19 Homo sapiens Q96E35
Validated Y2H
32296183
Intra TOX4 O94842 GEMIN6 Homo sapiens Q8WXD5
Y2H Array
25416956
Intra TOX4 O94842 GEMIN6 Homo sapiens Q8WXD5
Y2H Prey Pooling
25416956
Intra TOX4 O94842 ATXN1 Homo sapiens P54253
Y2H Pooling
32814053
Intra TOX4 O94842 ATXN1 Homo sapiens P54253
Validated Y2H
32814053
Intra TOX4 O94842 ATXN1 Homo sapiens P54253
Y2H Array
32814053
Intra TOX4 O94842 ATXN1 Homo sapiens P54253
Y2H
16713569
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Breast Intraductal Papillomatosis

Breast Papillomatosis

Intraductal Papillomatosis Of The Breast
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14911 TOX4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta TOX4 VGNC VGNC:99334
Rattus norvegicus TOX4 RGD RGD:708449
Canis familiaris TOX4 VGNC VGNC:55005
Felis catus TOX4 VGNC VGNC:66460
Bos taurus TOX4 VGNC VGNC:36230
Mus musculus TOX4 MGD MGI:1915389
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