NR1D2 - nuclear receptor subfamily 1 group D member 2 Gene

中文名称：核受体亚家族 1 D 组成员 2

种属: Homo sapiens

同用名: RVR; BD73; EAR-1R; REVERBB; REVERBbeta

基因 ID: 9975 | 基因类型: protein coding

关于 NR1D2

Cytogenetic location: 3p24.2 Genomic coordinates (GRCh38): 3:23,945,286-23,980,617 (from NCBI)

This gene has 5 transcripts (splice variants), 474 orthologues and 18 paralogues. Ubiquitous expression in thyroid (RPKM 35.4), ovary (RPKM 18.9) and 25 other tissues.

功能概要

该基因编码核激素受体家族的一个成员，特别是受体的 NR1 亚家族。编码的蛋白质起转录抑制因子的作用，可能在昼夜节律以及碳水化合物和脂质代谢中发挥作用。已经描述了选择性剪接的转录物变体。[RefSeq 提供，2009 年 2 月]

This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

NR1D2 基因产物(2)

mRNA	Protein	Name
NM_001145425.2	NP_001138897.1	nuclear receptor subfamily 1 group D member 2 isoform 2
NM_005126.5	NP_005117.3	nuclear receptor subfamily 1 group D member 2 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	17892483	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17892483	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	17892483	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	17892483	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NR1D2 蛋白结构

zf-C4

Hormone_recep

0
100
200
300
400
500
579 a.a.

蛋白主名

其他名称

nuclear receptor subfamily 1 group D member 2

V-erbA-related protein 1-related

NR1D2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	NR1D2	Q14995	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
种属内	NR1D2	Q14995	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
种属内	NR1D2	Q14995	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
种属内	NR1D2	Q14995	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
种属内	NR1D2	Q14995	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
种属内	NR1D2	Q14995	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
种属内	NR1D2	Q14995	GRN	Homo sapiens	P28799-2	Y2H Pooling	32814053
种属内	NR1D2	Q14995	GRN	Homo sapiens	P28799-2	Validated Y2H	32814053
种属内	NR1D2	Q14995	GRN	Homo sapiens	P28799-2	Y2H Array	32814053
种属内	NR1D2	Q14995	q9y649_human	Homo sapiens	Q9Y649	Validated Y2H	32814053
种属内	NR1D2	Q14995	q9y649_human	Homo sapiens	Q9Y649	Y2H Array	32814053
种属内	NR1D2	Q14995	q9y649_human	Homo sapiens	Q9Y649	Y2H Pooling	32814053
种属内	NR1D2	Q14995	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
种属内	NR1D2	Q14995	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
种属内	NR1D2	Q14995	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
种属内	NR1D2	Q14995	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
种属内	NR1D2	Q14995	GSN	Homo sapiens	P06396	Validated Y2H	32814053
种属内	NR1D2	Q14995	GSN	Homo sapiens	P06396	Y2H Array	32814053
种属内	NR1D2	Q14995	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
种属内	NR1D2	Q14995	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
种属内	NR1D2	Q14995	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
种属内	NR1D2	Q14995	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
种属内	NR1D2	Q14995	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
种属内	NR1D2	Q14995	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
种属内	NR1D2	Q14995	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
种属内	NR1D2	Q14995	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
种属内	NR1D2	Q14995	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
种属内	NR1D2	Q14995	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
种属内	NR1D2	Q14995	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
种属内	NR1D2	Q14995	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
种属内	NR1D2	Q14995	WFS1	Homo sapiens	O76024	Y2H Array	32814053
种属内	NR1D2	Q14995	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
种属内	NR1D2	Q14995	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
种属内	NR1D2	Q14995	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32814053
种属内	NR1D2	Q14995	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32814053
种属内	NR1D2	Q14995	UBQLN1	Homo sapiens	Q9UMX0	Y2H Pooling	32814053
种属内	NR1D2	Q14995	GRN	Homo sapiens	P28799	Y2H Pooling	32814053
种属内	NR1D2	Q14995	GRN	Homo sapiens	P28799	Validated Y2H	32814053
种属内	NR1D2	Q14995	GRN	Homo sapiens	P28799	Y2H Array	32814053
种属间	NR1D2	Q14995	Clock	Mus musculus	O08785	Anti Tag CoIP	23555304

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Atrioventricular Septal Defect

AVSD	Atrioventricular Canal Defect
Avcd	Endocardial Cushion Defect
Ecd	Avc Defect
Atrioventricular Septal Defect, Susceptibility To, 1	Atrioventricular Septal Defect 1
Endocardial Cushion Defects	Septal Defect, Atrioventricular
Atrioventricular Defect With Atrial Shunting Only	Incomplete Atrioventricular Septal Defect With Isolated Atrial Component
Incomplete Atrioventricular Canal Defect With Isolated Atrial Component	Primum Atrial Septal Defect
Partial Atrioventricular Canal Defect With Isolated Atrial Component	Partial Atrioventricular Septal Defect, Ostium Primum Type
Ostium Primum Atrial Septal Defect	Partial Atrioventricular Canal Defect
Partial Atrioventricular Septal Defect	Atrial Septum Primum Defect
Atrioventricular Canal Defect With Isolated Ventricular Component	Atrioventricular Canal Defect With Isolated Ventricular Communication
Atrioventricular Septal Defect With Isolated Ventricular Component	Atrioventricular Septal Defect With Atrial Shunting And Restrictive Ventricular Shunting
Intermediate Atrioventricular Canal Defect With Atrial And Ventricular Components And Separate Atrioventricular Valve	Transitional Atrioventricular Septal Defect With Atrial And Ventricular Components And Separate Atrioventricular Valves
Atrioventricular Canal Defect Associated With A Restrictive Ventricular Septal Defect	Intermediate Atrioventricular Canal Defect
Intermediate Atrioventricular Septal Defect With Atrial And Ventricular Components And Separate Atrioventricular Valvar Orifices	Intermediate Atrioventricular Septal Defect
Transitional Atrioventricular Canal Defect	Transitional Atrioventricular Septal Defect
Complete Atrioventricular Canal With Atrial And Ventricular Components	Complete Atrioventricular Canal Defect
Complete Atrioventricular Septal Defect

Delayed Sleep Phase Disorder

Delayed Sleep Phase Syndrome	Delayed Sleep Phase Syndrome, Susceptibility To
DSPD	Delayed Sleep Phase Disorder, Susceptibility To
DSPS	Sleep Phase, Delayed, Disorder
Sleep Phase Syndrome, Delayed, Susceptibility To

Advanced Sleep Phase Syndrome

Fasps	Familial Advanced Sleep-Phase Syndrome
Advanced Sleep Phase Syndrome, Familial	Familial Advanced Sleep Phase Syndrome
Sleep Phase Syndrome, Advanced, Familial	Advanced Sleep-Phase Syndrome, Familial

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09528	NR1D2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	NR1D2	MGD	MGI:2449205
Canis familiaris	NR1D2	VGNC	VGNC:43941
Felis catus	NR1D2	VGNC	VGNC:68543
Macaca mulatta	NR1D2	VGNC	VGNC:75503
Bos taurus	NR1D2	VGNC	VGNC:32229
Rattus norvegicus	NR1D2	RGD	RGD:628828

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

NR1D2 - nuclear receptor subfamily 1 group D member 2 Gene

关于 NR1D2

功能概要

NR1D2 基因产物(2)

NR1D2 蛋白结构

NR1D2 蛋白互作信息

关联疾病

直系同源

热门区域

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NR1D2 - nuclear receptor subfamily 1 group D member 2 Gene

关于 NR1D2

功能概要

NR1D2 基因产物(2)

NR1D2 蛋白结构

NR1D2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z