Kdm1a - lysine (K)-specific demethylase 1A Gene

中文名称：赖氨酸 (K) 特异性脱甲基酶 1A

种属: Mus musculus

同用名: Aof2; Kdm1; Lsd1; mKIAA0601; D4Ertd478e; 1810043O07Rik

基因 ID: 99982 | 基因类型: protein coding

关于 Kdm1a

Chromosome 4: 136,277,851-136,330,034 reverse strand.GRCm39:CM000997.3

This gene has 9 transcripts (splice variants), 215 orthologues, 9 paralogues and is associated with 39 phenotypes. Ubiquitous expression in CNS E14 (RPKM 42.5), whole brain E14.5 (RPKM 4.5) and 28 other tissues.

功能概要

该基因编码的蛋白可启动多种功能，包括 DNA 结合转录因子结合活性；组蛋白 H3-di/monomethyl-lysine-4 FAD 依赖性脱甲基酶活性；和启动子特异性染色质结合活性。参与多个过程，包括大分子代谢过程的负调控；细胞群增殖的正向调节；和骨髓细胞分化的调节。作用于组蛋白 H3-K4 去甲基化的上游或内部；神经系统发育；和 RNA 聚合酶 II 对转录的正调控。位于染色质和细胞核中。以多种结构表达，包括大脑；内细胞团；生殖系统;视网膜；和泌尿系统。与人 KDM1A（赖氨酸脱甲基酶 1A）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including DNA-binding transcription factor binding activity; histone H3-di/monomethyl-lysine-4 FAD-dependent demethylase activity; and promoter-specific chromatin binding activity. Involved in several processes, including negative regulation of macromolecule metabolic process; positive regulation of cell population proliferation; and regulation of myeloid cell differentiation. Acts upstream of or within histone H3-K4 demethylation; nervous system development; and positive regulation of transcription by RNA polymerase II. Located in chromatin and nucleus. Is expressed in several structures, including brain; inner cell mass; reproductive system; retina; and urinary system. Orthologous to human KDM1A (lysine demethylase 1A). [provided by Alliance of Genome Resources, Apr 2022]

Kdm1a 基因产物(3)

mRNA	Protein	Name
NM_001347221.1	NP_001334150.1	lysine-specific histone demethylase 1A isoform 1
NM_001356567.1	NP_001343496.1	lysine-specific histone demethylase 1A isoform 3
NM_133872.2	NP_598633.2	lysine-specific histone demethylase 1A isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	20833138	MGI
enables FAD-dependent H3K4me/H3K4me3 demethylase activity	IDA IDA: 通过直接分析推断	24843136	MGI
enables MRF binding	IPI IPI: 通过物理相互作用推断	20833138	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	28053041	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	20123967	MGI
enables chromatin binding	IDA IDA: 通过直接分析推断	17392792	MGI
enables enzyme binding	IPI IPI: 通过物理相互作用推断	17277772	MGI
enables histone H3K4 demethylase activity	IMP IMP: 通过突变表型推断	24217620	MGI
enables histone H3K9me2/H3K9me3 demethylase activity	IMP IMP: 通过突变表型推断	20833138	MGI
enables lncRNA binding	IDA IDA: 通过直接分析推断	27618650	MGI
enables promoter-specific chromatin binding	IDA IDA: 通过直接分析推断	19497860	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	17296600	MGI
enables transcription coactivator activity	IMP IMP: 通过突变表型推断	20123967	MGI
enables transcription corepressor activity	IDA IDA: 通过直接分析推断	17707228	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within DNA repair-dependent chromatin remodeling	IDA IDA: 通过直接分析推断	24217620	MGI
acts upstream of or within cell differentiation	IMP IMP: 通过突变表型推断	17392792	MGI
involved in granulocyte differentiation	IMP IMP: 通过突变表型推断	17707228	MGI
involved in muscle cell development	IMP IMP: 通过突变表型推断	20833138	MGI
acts upstream of or within negative regulation of neurogenesis	IDA IDA: 通过直接分析推断	25018020	MGI
acts upstream of or within negative regulation of neurogenesis	IMP IMP: 通过突变表型推断	25018020	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	19497860	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	17392792	MGI
acts upstream of or within neuron projection extension	IGI IGI: 通过遗传相互作用推断	25018020	MGI
acts upstream of or within neuron projection extension	IMP IMP: 通过突变表型推断	25018020	MGI
acts upstream of or within pituitary gland development	IMP IMP: 通过突变表型推断	17392792	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: 通过突变表型推断	27566776	MGI
involved in positive regulation of erythrocyte differentiation	IMP IMP: 通过突变表型推断	17707228	MGI
involved in positive regulation of megakaryocyte differentiation	IMP IMP: 通过突变表型推断	17707228	MGI
involved in positive regulation of neural precursor cell proliferation	IMP IMP: 通过突变表型推断	20123967	MGI
involved in positive regulation of stem cell proliferation	IMP IMP: 通过突变表型推断	20123967	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	17392792	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	20123967	MGI
acts upstream of or within regulation of neurogenesis	IGI IGI: 通过遗传相互作用推断	25018020	MGI
involved in regulation of primitive erythrocyte differentiation	IMP IMP: 通过突变表型推断	17707228	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	17392792	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in chromatin	IDA IDA: 通过直接分析推断	20833138	MGI
located in nucleus	IDA IDA: 通过直接分析推断	19497860	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Kdm1a 蛋白结构

PHA03378

PLN02328

0
200
400
600
800
873 a.a.

蛋白主名

其他名称

lysine-specific histone demethylase 1A

BRAF35-HDAC complex protein BHC110	amine oxidase (flavin containing) domain 2
flavin-containing amine oxidase domain-containing protein 2	lysine (K)-specific demethylase 1
lysine-specific histone demethylase 1

Kdm1a 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	Kdm1a	Q6ZQ88	Rcor1	Mus musculus	Q8CFE3	Anti Bait CoIP	17392792
种属内	Kdm1a	Q6ZQ88	Cebpa	Mus musculus	P53566	Anti Bait CoIP	26974661
种属内	Kdm1a	Q6ZQ88	Hdac1	Mus musculus	O09106	Anti Bait CoIP	26974661
种属内	Kdm1a	Q6ZQ88	Hdac1	Mus musculus	O09106	Anti Bait CoIP	20404188
种属内	Kdm1a	Q6ZQ88	Hdac1	Mus musculus	O09106	Anti Bait CoIP	22297846
种属内	Kdm1a	Q6ZQ88	Hdac2	Mus musculus	P70288	Anti Bait CoIP	20404188
种属内	Kdm1a	Q6ZQ88	Rnf2	Mus musculus	Q9CQJ4	Anti Bait CoIP	17296600

种属间: 跨种属相互作用 种属内: 同种属相互作用

目录号	产品名	作用方式	纯度	Phase
HY-18632	GSK2879552	Inhibitor	99.90%	Phase 2
HY-103713	Seclidemstat	Inhibitor	99.77%	Phase 2
HY-18632A	GSK2879552 dihydrochloride	Inhibitor	99.19%	Phase 2
HY-109117	Iadademstat	Inhibitor	99.61%	Phase 2
HY-12782T	Iadademstat dihydrochloride	Inhibitor	99.98%	Phase 1
HY-138830	TAK-418	Inhibitor	99.10%	Phase 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-103713A	Seclidemstat mesylate	Inhibitor	99.60%	否
HY-19612B	DDP-38003 trihydrochloride	Inhibitor	/	否
HY-19612A	DDP-38003 dihydrochloride	Inhibitor	98.22%	否
HY-112304	NCD38 TFA	Inhibitor	/	否
HY-112304A	(1R,2S)-NCD38 TFA	Inhibitor	/	否
HY-143238	FY-56	Inhibitor	/	否
HY-RS07205	KDM1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS07206	Kdm1a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS07207	Kdm1a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Kdm1a	NCBI	NCBI:23028

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