Rnf2 - ring finger protein 2 Gene

种属: Mus musculus

同用名: dinG; Ring1B

基因 ID: 19821 | 基因类型: protein coding

关于 Rnf2

功能概要

Enables chromatin binding activity and ubiquitin protein Ligase activity. Involved in germ cell development and histone H2A-K119 monoubiquitination. Acts upstream of or within with a negative effect on gene expression. Acts upstream of or within several processes, including gastrulation with mouth forming second; histone ubiquitination; and negative regulation of transcription by RNA polymerase II. Located in euchromatin; nuclear body; and sex chromatin. Part of PcG protein complex and ubiquitin Ligase complex. Is expressed in several structures, including central nervous system; limb; ovary; retina; and urinary system. Orthologous to human RNF2 (ring finger protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Rnf2 基因产物(4)

mRNA	Protein	Name
NM_001360844.1	NP_001347773.1	E3 ubiquitin-protein ligase RING2 isoform a
NM_001360845.1	NP_001347774.1	E3 ubiquitin-protein ligase RING2 isoform b
NM_001360847.1	NP_001347776.1	E3 ubiquitin-protein ligase RING2 isoform b
NM_011277.3	NP_035407.1	E3 ubiquitin-protein ligase RING2 isoform b

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables chromatin binding	IDA IDA: 通过直接分析推断	12183370	MGI
enables histone H2AK119 ubiquitin ligase activity	IMP IMP: 通过突变表型推断	24034696	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	9627119	MGI
enables ubiquitin protein ligase activity	IDA IDA: 通过直接分析推断	16359901	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within anterior/posterior axis specification	IMP IMP: 通过突变表型推断	12183370	MGI
acts upstream of or within positive effect chromatin organization	IDA IDA: 通过直接分析推断	16359901	MGI
acts upstream of or within positive effect chromatin organization	IGI IGI: 通过遗传相互作用推断	15525528	MGI
acts upstream of or within gastrulation with mouth forming second	IMP IMP: 通过突变表型推断	12589020	MGI
acts upstream of or within negative effect gene expression	IMP IMP: 通过突变表型推断	23027973	MGI
involved in germ cell development	IMP IMP: 通过突变表型推断	23486062	MGI
acts upstream of or within mitotic cell cycle	IMP IMP: 通过突变表型推断	12589020	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	16687444	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	24034696	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of PRC1 complex	IDA IDA: 通过直接分析推断	16359901	MGI
part of PcG protein complex	IDA IDA: 通过直接分析推断	16624538	MGI
is active in cytoplasm	IDA IDA: 通过直接分析推断	24980959	MGI
located in euchromatin	IDA IDA: 通过直接分析推断	18311137	MGI
located in heterochromatin	IDA IDA: 通过直接分析推断	18311137	MGI
located in nuclear body	IDA IDA: 通过直接分析推断	12183370	MGI
is active in nucleus	IDA IDA: 通过直接分析推断	24980959	MGI
located in nucleus	IDA IDA: 通过直接分析推断	14557078	MGI
located in sex chromatin	IDA IDA: 通过直接分析推断	15525528	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

E3 ubiquitin-protein ligase RING2

RING finger protein 1B

RING-type E3 ubiquitin transferase RING2

Rnf2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	Rnf2	Q9CQJ4	Skp1	Mus musculus	Q9WTX5	Pull Down	17296600
种属内	Rnf2	Q9CQJ4	Skp1	Mus musculus	Q9WTX5	Anti Bait CoIP	17296600
种属内	Rnf2	Q9CQJ4	Kdm2b	Mus musculus	Q6P1G2	Pull Down	17296600
种属内	Rnf2	Q9CQJ4	Kdm2b	Mus musculus	Q6P1G2	Anti Bait CoIP	17296600
种属内	Rnf2	Q9CQJ4	Kdm1a	Mus musculus	Q6ZQ88	Anti Bait CoIP	17296600
种属内	Rnf2	Q9CQJ4	Kdm1a	Mus musculus	Q6ZQ88	Pull Down	17296600
种属内	Rnf2	Q9CQJ4	Csnk2a1	Mus musculus	Q61177	Anti Bait CoIP	17296600
种属内	Rnf2	Q9CQJ4	Csnk2a1	Mus musculus	Q61177	Pull Down	17296600
种属内	Rnf2	Q9CQJ4	Cbx8	Mus musculus	Q9QXV1	Anti Bait CoIP	17296600
种属内	Rnf2	Q9CQJ4	Cbx8	Mus musculus	Q9QXV1	Pull Down	17296600
种属内	Rnf2	Q9CQJ4	Phc2	Mus musculus	Q9QWH1	Anti Bait CoIP	16024804
种属内	Rnf2	Q9CQJ4	Phc2	Mus musculus	Q9QWH1	Pull Down	17296600
种属内	Rnf2	Q9CQJ4	Phc2	Mus musculus	Q9QWH1	Y2H	9627119
种属内	Rnf2	Q9CQJ4	Phc2	Mus musculus	Q9QWH1	Pull Down	16359901
种属内	Rnf2	Q9CQJ4	Pcgf2	Mus musculus	P23798	Anti Bait CoIP	22325148
种属内	Rnf2	Q9CQJ4	Pcgf2	Mus musculus	P23798	Pull Down	17296600
种属内	Rnf2	Q9CQJ4	Pcgf2	Mus musculus	P23798	Y2H	12183370
种属内	Rnf2	Q9CQJ4	Pcgf2	Mus musculus	P23798	Anti Bait CoIP	12183370
种属内	Rnf2	Q9CQJ4	Phc1	Mus musculus	Q64028	Pull Down	17296600
种属内	Rnf2	Q9CQJ4	Phc1	Mus musculus	Q64028	Anti Bait CoIP	22325148
种属内	Rnf2	Q9CQJ4	Phc1	Mus musculus	Q64028	Pull Down	18650381
种属内	Rnf2	Q9CQJ4	Bmi1	Mus musculus	P25916	Pull Down	17296600
种属内	Rnf2	Q9CQJ4	Bmi1	Mus musculus	P25916	Pull Down	18650381
种属内	Rnf2	Q9CQJ4	Bmi1	Mus musculus	P25916	Y2H	9627119
种属内	Rnf2	Q9CQJ4	Bmi1	Mus musculus	P25916	GMS	18650381
种属内	Rnf2	Q9CQJ4	Bmi1	Mus musculus	P25916	Pull Down	16359901
种属内	Rnf2	Q9CQJ4	Bmi1	Mus musculus	P25916	Y2H	12183370
种属内	Rnf2	Q9CQJ4	Rybp	Mus musculus	Q8CCI5	Anti Bait CoIP	10369680
种属内	Rnf2	Q9CQJ4	Rybp	Mus musculus	Q8CCI5	Anti Bait CoIP	22325148
种属内	Rnf2	Q9CQJ4	Ring1	Mus musculus	O35730	Pull Down	16359901
种属内	Rnf2	Q9CQJ4	Ring1	Mus musculus	O35730	Pull Down	17296600
种属内	Rnf2	Q9CQJ4	Ring1	Mus musculus	O35730	Anti Bait CoIP	17296600

种属间: 跨种属相互作用 种属内: 同种属相互作用

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12074	RNF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Rnf2	NCBI	NCBI:6045

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