Griseofulvin-¹³C,d₃  (Synonyms: 灰黄霉素-¹³C,d₃)

Griseofulvin-¹³C,d₃ is the ¹³C- and deuterium labeled Griseofulvin[1].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[73].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

356.78

C₁₆¹³CH₁₄D₃ClO₆

1329612-29-4

126-07-8

灰黄霉素-¹³C,d₃；灰霉素-¹³C,d₃；微晶灰黄霉素-¹³C,d₃

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.  [Content Brief]

  [2]. Brilhante RSN, et al. In vitro activity of azole derivatives and griseofulvin against planktonic and biofilm growth of clinical isolates of dermatophytes. Mycoses. 2018 Jul;61(7):449-454.  [Content Brief]

  [3]. Schmeel LC, et al. Griseofulvin Efficiently Induces Apoptosis in In Vitro Treatment of Lymphoma and Multiple Myeloma. Anticancer Res. 2017 May;37(5):2289-2295.  [Content Brief]