HDAC-IN-7 (Synonyms: Chidamide impurity)

目录号: HY-13592: FAQs
Data Sheet SDS 产品使用指南技术支持

HDAC-IN-7 (Chidamide impurity) 是 Chidamide 的一种杂质。Chidamide 是一种有效的，可口服的 HDAC 第 I 类 HDAC1/2/3 和第 IIb 类 HDAC10 抑制剂。

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HDAC-IN-7 Chemical Structure

CAS No. : 743420-02-2

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2 mg	￥1166	询问价格 & 货期
5 mg	￥1750	询问价格 & 货期
10 mg	￥3100	询问价格 & 货期

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HDAC-IN-7 相关产品

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查看所有亚型

HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

生物活性
纯度 & 产品资料

生物活性

HDAC-IN-7 (Chidamide impurity) is an impurity of Chidamide. Chidamide is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor.

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A-375	IC₅₀	4.11 μM Compound: CS055	Antiproliferative activity against human A375 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human A375 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 31991336]
A-375	IC₅₀	4.21 μM Compound: CS055; HBI-8000	Antiproliferative activity against human A375 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human A375 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 31003060]
A-375	IC₅₀	4.77 μM Compound: CS055; HBI-8000	Antiproliferative activity against human A375 cells assessed as decrease in cell viability after 72 hrs by CCK-8 assay Antiproliferative activity against human A375 cells assessed as decrease in cell viability after 72 hrs by CCK-8 assay	[PMID: 31103900]
A-375	IC₅₀	6.72 μM Compound: CS055	Antiproliferative activity against human A-375 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human A-375 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 32361064]
A-375	IC₅₀	7.67 μM Compound: CS055	Antiproliferative activity against human A375 cells after 72 hrs by CCK-8 assay Antiproliferative activity against human A375 cells after 72 hrs by CCK-8 assay	[PMID: 29202397]
A549	IC₅₀	0.665 μM Compound: Chidamide	Antiproliferative activity against human A549 cells after 48 to 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 to 72 hrs by MTT assay	[PMID: 28532668]
A549	IC₅₀	11.02 μM Compound: CS055; HBI-8000	Antiproliferative activity against human A549 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human A549 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 31003060]
A549	IC₅₀	11.02 μM Compound: 4; CS055	Antiproliferative activity against human A549 cells after 72 hrs by CCK-8 reagent based assay Antiproliferative activity against human A549 cells after 72 hrs by CCK-8 reagent based assay	[PMID: 28391133]
A549	IC₅₀	6.81 μM Compound: CS055; HBI-8000	Antiproliferative activity against human A549 cells assessed as decrease in cell viability after 72 hrs by CCK-8 assay Antiproliferative activity against human A549 cells assessed as decrease in cell viability after 72 hrs by CCK-8 assay	[PMID: 31103900]
DLD-1	IC₅₀	> 4 μM Compound: 4	Cytotoxicity against human DLD-1 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay Cytotoxicity against human DLD-1 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay	[PMID: 33588178]
HCT-116	IC₅₀	0.202 μM Compound: Chidamide	Antiproliferative activity against human HCT116 cells after 48 to 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 48 to 72 hrs by MTT assay	[PMID: 28532668]
HCT-116	IC₅₀	1.54 μM Compound: 4	Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay	[PMID: 33588178]
HCT-116	IC₅₀	1.57 μM Compound: CS055; HBI-8000	Antiproliferative activity against human HCT116 cells assessed as decrease in cell viability after 72 hrs by CCK-8 assay Antiproliferative activity against human HCT116 cells assessed as decrease in cell viability after 72 hrs by CCK-8 assay	[PMID: 31103900]
HCT-116	IC₅₀	149 μM Compound: CS055	Antiproliferative activity against human HCT-116 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human HCT-116 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 32361064]
HCT-116	IC₅₀	2.28 μM Compound: CS055; HBI-8000	Antiproliferative activity against human HCT116 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human HCT116 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 31003060]
HCT-116	IC₅₀	2.28 μM Compound: CS055	Antiproliferative activity against human HCT116 cells after 72 hrs by CCK-8 assay Antiproliferative activity against human HCT116 cells after 72 hrs by CCK-8 assay	[PMID: 29202397]
HCT-116	IC₅₀	2.28 μM Compound: 4; CS055	Antiproliferative activity against human HCT116 cells after 72 hrs by CCK-8 reagent based assay Antiproliferative activity against human HCT116 cells after 72 hrs by CCK-8 reagent based assay	[PMID: 28391133]
HCT-116	IC₅₀	2.77 μM Compound: CS055	Antiproliferative activity against human HCT116 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human HCT116 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 31991336]
HEK293	IC₅₀	32 μM Compound: Chidamide	Inhibition of recombinant human ERG expressed in HEK293 cells after 9 mins by patch clamp method Inhibition of recombinant human ERG expressed in HEK293 cells after 9 mins by patch clamp method	[PMID: 28532668]
HeLa	IC₅₀	> 4 μM Compound: 4	Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay	[PMID: 33588178]
HeLa	IC₅₀	0.9 μM Compound: CS055; HBI-8000	Inhibition of HDAC in human HeLa cell nuclear extract assessed as decrease in deacetylation of FLUOR DE LYS Green substrate preincubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence based assay Inhibition of HDAC in human HeLa cell nuclear extract assessed as decrease in deacetylation of FLUOR DE LYS Green substrate preincubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence based assay	[PMID: 31103900]
HeLa	IC₅₀	0.9 μM Compound: CS055; HBI-8000	Inhibition of HDAC in human HeLa cell nuclear extract using fluor-de-lys-green as substrate preincubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence assay Inhibition of HDAC in human HeLa cell nuclear extract using fluor-de-lys-green as substrate preincubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence assay	[PMID: 31003060]
HeLa	IC₅₀	10.97 μM Compound: CS055	Antiproliferative activity against human HeLa cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human HeLa cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 32361064]
HeLa	IC₅₀	11.83 μM Compound: CS055	Antiproliferative activity against human HeLa cells after 72 hrs by CCK-8 assay Antiproliferative activity against human HeLa cells after 72 hrs by CCK-8 assay	[PMID: 29202397]
HeLa	IC₅₀	12.59 μM Compound: CS055; HBI-8000	Antiproliferative activity against human HeLa cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human HeLa cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 31003060]
HeLa	IC₅₀	14.94 μM Compound: CS055	Antiproliferative activity against human Hela cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human Hela cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 31991336]
HeLa	IC₅₀	3.42 μM Compound: CS055; HBI-8000	Antiproliferative activity against human HeLa cells assessed as decrease in cell viability after 72 hrs by CCK-8 assay Antiproliferative activity against human HeLa cells assessed as decrease in cell viability after 72 hrs by CCK-8 assay	[PMID: 31103900]
HepG2	IC₅₀	> 8 μM Compound: 6	Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 32325365]
HepG2	IC₅₀	11.67 μM Compound: CS055	Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 32361064]
HepG2	IC₅₀	22.65 μM Compound: 4; CS055	Antiproliferative activity against human HepG2 cells after 72 hrs by CCK-8 reagent based assay Antiproliferative activity against human HepG2 cells after 72 hrs by CCK-8 reagent based assay	[PMID: 28391133]
HH	IC₅₀	> 1 μM Compound: 4	Cytotoxicity against human HH cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay Cytotoxicity against human HH cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay	[PMID: 33588178]
HL-60	IC₅₀	0.48 μM Compound: 4	Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay	[PMID: 33588178]
HuT78	IC₅₀	> 1 μM Compound: 4	Cytotoxicity against human HuT78 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay Cytotoxicity against human HuT78 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay	[PMID: 33588178]
K562	GI₅₀	0.45 μM Compound: Chidamide	Antiproliferative activity against human K562 cells assessed as cell growth inhibition by MTT assay Antiproliferative activity against human K562 cells assessed as cell growth inhibition by MTT assay	[PMID: 32088129]
K562	IC₅₀	0.975 μM Compound: Chidamide	Antiproliferative activity against human K562 cells after 48 to 72 hrs by MTT assay Antiproliferative activity against human K562 cells after 48 to 72 hrs by MTT assay	[PMID: 28532668]
KG-1	IC₅₀	0.49 μM Compound: 4	Cytotoxicity against human KG-1 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay Cytotoxicity against human KG-1 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay	[PMID: 33588178]
MCF7	GI₅₀	1.43 μM Compound: Chidamide	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition by MTT assay Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition by MTT assay	[PMID: 32088129]
MDA-MB-231	GI₅₀	2.88 μM Compound: Chidamide	Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition by MTT assay	[PMID: 32088129]
MDA-MB-231	IC₅₀	3.41 μM Compound: 4	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay	[PMID: 33588178]
MDA-MB-231	IC₅₀	3.6 μM Compound: 6	Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 32325365]
MDA-MB-468	IC₅₀	> 4 μM Compound: 4	Cytotoxicity against human MDA-MB-468 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay Cytotoxicity against human MDA-MB-468 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay	[PMID: 33588178]
MGC-803	IC₅₀	6.44 μM Compound: CS055	Antiproliferative activity against human MGC803 cells after 72 hrs by CCK-8 assay Antiproliferative activity against human MGC803 cells after 72 hrs by CCK-8 assay	[PMID: 29202397]
MGC-803	IC₅₀	6.44 μM Compound: 4; CS055	Antiproliferative activity against human MGC803 cells after 72 hrs by CCK-8 reagent based assay Antiproliferative activity against human MGC803 cells after 72 hrs by CCK-8 reagent based assay	[PMID: 28391133]
MRC5	IC₅₀	> 30 μM Compound: Chidamide	Antiproliferative activity against human MRC5 cells after 48 to 72 hrs by MTT assay Antiproliferative activity against human MRC5 cells after 48 to 72 hrs by MTT assay	[PMID: 28532668]
NCI-H1299	IC₅₀	16.26 μM Compound: CS055	Antiproliferative activity against human NCI-H1299 cells after 72 hrs by CCK-8 assay Antiproliferative activity against human NCI-H1299 cells after 72 hrs by CCK-8 assay	[PMID: 29202397]
NCI-H460	IC₅₀	> 32 μM Compound: CS055	Antiproliferative activity against human H460 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human H460 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 31991336]
NCI-H460	IC₅₀	13.34 μM Compound: CS055	Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 32361064]
NIH3T3	IC₅₀	2.37 μM Compound: CS055; HBI-8000	Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability after 48 hrs by CCK8 assay Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability after 48 hrs by CCK8 assay	[PMID: 31003060]
NIH3T3	IC₅₀	2.37 μM Compound: CS055; HBI-8000	Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability after 72 hrs by CCK-8 assay Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability after 72 hrs by CCK-8 assay	[PMID: 31103900]
PC-3	IC₅₀	2.093 μM Compound: Chidamide	Antiproliferative activity against human PC3 cells after 48 to 72 hrs by MTT assay Antiproliferative activity against human PC3 cells after 48 to 72 hrs by MTT assay	[PMID: 28532668]
SMMC-7721	IC₅₀	> 26 μM Compound: CS055; HBI-8000	Antiproliferative activity against human SMMC7721 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human SMMC7721 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 31003060]
SMMC-7721	IC₅₀	> 26 μM Compound: CS055	Antiproliferative activity against human SMMC7721 cells after 72 hrs by CCK-8 assay Antiproliferative activity against human SMMC7721 cells after 72 hrs by CCK-8 assay	[PMID: 29202397]
SMMC-7721	IC₅₀	25.59 μM Compound: CS055	Antiproliferative activity against human SMMC7721 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human SMMC7721 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 31991336]
SMMC-7721	IC₅₀	8.63 μM Compound: CS055; HBI-8000	Antiproliferative activity against human SMMC7721 cells assessed as decrease in cell viability after 72 hrs by CCK-8 assay Antiproliferative activity against human SMMC7721 cells assessed as decrease in cell viability after 72 hrs by CCK-8 assay	[PMID: 31103900]
U-937	CC₅₀	5 μM Compound: Chidamide	Cytotoxicity against human U937 cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human U937 cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 29541372]

分子量

390.41

Formula

C₂₂H₁₉FN₄O₂

CAS 号

743420-02-2

性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

纯度 & 产品资料

Data Sheet (493 KB) SDS (241 KB) 产品使用指南 (1538 KB)

HDAC-IN-7 相关分类

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC-IN-7743420-02-2Chidamide impurityHDACHistone deacetylasesInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

HDAC-IN-7 (Synonyms: Chidamide impurity)

Customer Review

HDAC-IN-7 相关产品

•同靶点产品:

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生物活性

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HDAC-IN-7 相关分类

摩尔计算器

稀释计算器

The molarity calculator equation

The dilution calculator equation

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HDAC-IN-7 (Synonyms: Chidamide impurity)

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HDAC-IN-7 相关抗体

HDAC-IN-7 相关产品

•同靶点产品:

•同靶点蛋白产品:

查看 HDAC 亚型特异性产品:

生物活性

纯度 & 产品资料

HDAC-IN-7 相关分类

摩尔计算器

稀释计算器

The molarity calculator equation

The dilution calculator equation

Keywords:

您最近查看的产品:

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