2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. HDAC6-IN-43

HDAC6-IN-43 (compound 26) 是一种有效的 HDAC 抑制剂。HDAC6-IN-43 可有效抑制多种 HDAC，特别是 HDAC1、HDAC2 和 HDAC6 (IC50 < 150 nM)，对 HDAC6 表现出特别高的敏感性 (IC50 = 11 nM)。HDAC6-IN-43 可用于研究常染色体显性多囊肾病 (ADPKD)。

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HDAC6-IN-43 Chemical Structure

HDAC6-IN-43 Chemical Structure

CAS No. : 3037978-19-8

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HDAC6-IN-43 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC6-IN-43 (compound 26) is a potent HDAC inhibitor. HDAC6-IN-43 effectively inhibits several HDACs, notably HDAC1, HDAC2, and HDAC6 (IC50 < 150 nM), displaying a particularly high sensitivity towards HDAC6 (IC50 = 11 nM). HDAC6-IN-43 can be used for the research of autosomal dominant polycystic kidney disease (ADPKD)[1].

IC50 & Target

HDAC6

11 ± 1 nM (IC50)

HDAC2

105 ± 5 nM (IC50)

HDAC1

111 ± 5 nM (IC50)

HDAC8

15404 ± 99 nM (IC50)

体外研究
(In Vitro)

HDAC6-IN-43 (compound 26) 通过上调 α-微管蛋白乙酰化水平显着抑制 Madin-Darby 犬肾 (MDCK) 细胞的生长和增殖[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC6-IN-43 相关抗体:
分子量

400.49

Formula

C21H24N2O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC6-IN-43 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC6-IN-433037978-19-8HDACHistone deacetylasesMadin-Darby canine kidneyMDCKα-tubulinautosomal dominant polycystic kidney diseaseADPKDInhibitorinhibitorinhibit

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目录号：
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