1. Apoptosis
  2. Apoptosis
  3. HOE 689

HOE 689  (Synonyms: Ramnodigin)

目录号: HY-164033
产品使用指南

HOE 689 (Ramnodigin) 是 Digitoxin (HY-B1357) 的类似物。HOE 689 对肺癌细胞表现出细胞毒性,诱导 NCI-H460 细胞凋亡 (apoptosis),IC50 为 52 nM。

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HOE 689 Chemical Structure

HOE 689 Chemical Structure

CAS No. : 33156-28-4

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HOE 689 (Ramnodigin) is an analog of Digitoxin (HY-B1357). HOE 689 exhibits cytotoxicity to lung cancer cells and induces apoptosis in cancer cell NCI-H460 with an IC50 of 52 nM[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
786-0 GI50
0.00621 μM
Compound: 7, mono-7
Cytotoxicity against human 786-0 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human 786-0 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
786-0 GI50
6.21 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human 786-0 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human 786-0 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
A498 GI50
0.0207 μM
Compound: 7, mono-7
Cytotoxicity against human A498 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human A498 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
A498 GI50
20.7 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human A498 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human A498 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
A549 GI50
0.00156 μM
Compound: 7, mono-7
Cytotoxicity against human A549 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human A549 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
A549 GI50
1.56 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human A549/ATCC cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human A549/ATCC cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
ACHN GI50
0.00431 μM
Compound: 7, mono-7
Cytotoxicity against human ACHN cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human ACHN cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
ACHN GI50
4.31 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human ACHN cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human ACHN cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
BT-549 GI50
2.41 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human BT549 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human BT549 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
CAKI-1 GI50
3.32 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human Caki1 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human Caki1 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
CCRF-CEM GI50
8.49 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human CCRF-CEM cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human CCRF-CEM cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
COLO 205 GI50
0.0296 μM
Compound: 7, mono-7
Cytotoxicity against human COLO205 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human COLO205 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
COLO 205 GI50
29.6 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human COLO205 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human COLO205 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
DU-145 GI50
0.00345 μM
Compound: 7, mono-7
Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
DU-145 GI50
3.45 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
EKVX GI50
0.00513 μM
Compound: 7, mono-7
Cytotoxicity against human EKVX cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human EKVX cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
EKVX GI50
5.13 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human EKVX cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human EKVX cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
HCC 2998 GI50
16.5 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human HCC2998 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human HCC2998 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
HCT-15 GI50
0.0205 μM
Compound: 7, mono-7
Cytotoxicity against human HCT15 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human HCT15 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
HCT-15 GI50
20.5 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human HCT15 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human HCT15 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
HFF CC50
0.7 μM
Compound: 6, alpha-L-Amip-Dig
Cytotoxicity against HFF assessed as inhibition of cell viability after 3 days by MTT assay
Cytotoxicity against HFF assessed as inhibition of cell viability after 3 days by MTT assay
[PMID: 24900847]
HFF CC50
4 μM
Compound: 6, alpha-L-Amip-Dig
Cytotoxicity against HFF assessed as inhibition of cell viability after 3 days by trypan blue exclusion assay
Cytotoxicity against HFF assessed as inhibition of cell viability after 3 days by trypan blue exclusion assay
[PMID: 24900847]
HL-60(TB) GI50
2.96 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human HL-60(TB) cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human HL-60(TB) cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
HOP-62 GI50
0.00855 μM
Compound: 7, mono-7
Cytotoxicity against human HOP62 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human HOP62 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
HOP-62 GI50
8.55 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human HOP62 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human HOP62 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
HOP-92 GI50
0.0113 μM
Compound: 7, mono-7
Cytotoxicity against human HOP92 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human HOP92 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
HOP-92 GI50
11.3 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human HOP92 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human HOP92 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
Hs-578T GI50
0.00457 μM
Compound: 7, mono-7
Cytotoxicity against human Hs578T cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human Hs578T cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
Hs-578T GI50
4.57 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human Hs578T cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human Hs578T cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
HT-29 GI50
0.0119 μM
Compound: 7, mono-7
Cytotoxicity against human HT-29 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human HT-29 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
HT-29 GI50
11.9 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human HT-29 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human HT-29 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
IGROV-1 GI50
5.23 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human IGROV1 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human IGROV1 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
K562 GI50
19.5 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human K562 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human K562 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
KM12 GI50
0.0324 μM
Compound: 7, mono-7
Cytotoxicity against human KM12 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human KM12 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
KM12 GI50
32.4 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human KM12 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human KM12 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
LOX IMVI GI50
0.0118 μM
Compound: 7, mono-7
Cytotoxicity against human LOXIMVI cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human LOXIMVI cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
LOX IMVI GI50
11.8 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human LOXIMVI cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human LOXIMVI cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
M14 GI50
0.0193 μM
Compound: 7, mono-7
Cytotoxicity against human M14 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human M14 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
M14 GI50
19.3 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human M14 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human M14 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
Malme-3M GI50
0.0183 μM
Compound: 7, mono-7
Cytotoxicity against human MALME-3M cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human MALME-3M cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
Malme-3M GI50
18.3 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human MALME-3M cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human MALME-3M cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
MCF7 GI50
0.00589 μM
Compound: 7, mono-7
Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
MCF7 GI50
5.89 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
MDA-MB-231 GI50
0.0339 μM
Compound: 7, mono-7
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
MDA-MB-231 GI50
33.9 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
MDA-MB-435 GI50
0.0277 μM
Compound: 7, mono-7
Cytotoxicity against human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
MDA-MB-435 GI50
21 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human MDA-MB-435 breast cancer cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human MDA-MB-435 breast cancer cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
MDA-MB-435 GI50
27.7 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human MDA-MB-435 melanoma cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human MDA-MB-435 melanoma cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
MOLT-4 GI50
0.00257 μM
Compound: 7, mono-7
Cytotoxicity against human MOLT4 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human MOLT4 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
MOLT-4 GI50
2.57 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human MOLT4 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human MOLT4 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
NCI/ADR-RES GI50
4.12 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human NCI/ADR-RES cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human NCI/ADR-RES cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
NCI-H226 GI50
0.0193 μM
Compound: 7, mono-7
Cytotoxicity against human NCI-H226 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human NCI-H226 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
NCI-H226 GI50
19.3 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human NCI-H226 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human NCI-H226 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
NCI-H23 GI50
0.00413 μM
Compound: 7, mono-7
Cytotoxicity against human NCI-H23 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human NCI-H23 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
NCI-H23 GI50
4.13 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human NCI-H23 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human NCI-H23 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
NCI-H322M GI50
0.00778 μM
Compound: 7, mono-7
Cytotoxicity against human NCI-H322M cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human NCI-H322M cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
NCI-H322M GI50
7.78 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human NCI-H322M cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human NCI-H322M cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
NCI-H460 GI50
0.00383 μM
Compound: 7, mono-7
Cytotoxicity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
NCI-H460 GI50
1.927 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human NCI-H460 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against human NCI-H460 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 21572583]
NCI-H460 GI50
2 nM
Compound: 9, C5'-Me 9
Growth inhibition of human NCI-H460 cells after 48 hrs by MTT assay
Growth inhibition of human NCI-H460 cells after 48 hrs by MTT assay
[PMID: 21572583]
NCI-H460 GI50
2.2 nM
Compound: 7,alpha-L-amicetose
Growth inhibition of human NCI-H460 cells after 48 hrs by MTT assay
Growth inhibition of human NCI-H460 cells after 48 hrs by MTT assay
[PMID: 21643465]
NCI-H460 GI50
3.83 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
NCI-H460 IC50
47.98 nM
Compound: 7, mono-7
Cytotoxicity against human NCI-H460 cell assessed as cell death after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy
Cytotoxicity against human NCI-H460 cell assessed as cell death after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy
[PMID: 21660118]
NCI-H460 IC50
51.73 nM
Compound: 9, C5'-Me 9
Induction of apoptosis in human NCI-H460 cells in serum free medium after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy
Induction of apoptosis in human NCI-H460 cells in serum free medium after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy
[PMID: 21572583]
NCI-H460 IC50
52 nM
Compound: 9, C5'-Me 9
Cytotoxicity in human NCI-H460 cells in serum free medium at 50 nM after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy
Cytotoxicity in human NCI-H460 cells in serum free medium at 50 nM after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy
[PMID: 21572583]
NCI-H460 IC50
55.7 nM
Compound: 7,alpha-L-amicetose
Cytotoxicity against human NCI-H460 cells assessed as cell death at 50 nM after 12 hrs by Hoechst-33342 staining and propidium iodide staining
Cytotoxicity against human NCI-H460 cells assessed as cell death at 50 nM after 12 hrs by Hoechst-33342 staining and propidium iodide staining
[PMID: 21643465]
NCI-H522 GI50
0.00938 μM
Compound: 7, mono-7
Cytotoxicity against human NCI-H522 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human NCI-H522 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
NCI-H522 GI50
9.38 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human NCI-H522 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human NCI-H522 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
OVCAR-3 GI50
0.00494 μM
Compound: 7, mono-7
Cytotoxicity against human OVCAR3 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human OVCAR3 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
OVCAR-3 GI50
4.94 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human OVCAR3 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human OVCAR3 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
OVCAR-4 GI50
0.0189 μM
Compound: 7, mono-7
Cytotoxicity against human OVCAR4 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human OVCAR4 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
OVCAR-4 GI50
18.9 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human OVCAR4 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human OVCAR4 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
OVCAR-5 GI50
17.4 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human OVCAR5 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human OVCAR5 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
OVCAR-8 GI50
0.0025 μM
Compound: 7, mono-7
Cytotoxicity against human OVCAR8 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human OVCAR8 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
OVCAR-8 GI50
2.5 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human OVCAR8 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human OVCAR8 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
PC-3 GI50
0.00955 μM
Compound: 7, mono-7
Cytotoxicity against human PC3 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human PC3 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
PC-3 GI50
9.55 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human PC3 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human PC3 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
RPMI-8226 GI50
0.0235 μM
Compound: 7, mono-7
Cytotoxicity against human RPMI8226 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human RPMI8226 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
RPMI-8226 GI50
23.5 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human RPMI8226 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human RPMI8226 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
RXF 393 GI50
1.22 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human RXF393 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human RXF393 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
SF-268 GI50
0.00428 μM
Compound: 7, mono-7
Cytotoxicity against human SF268 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SF268 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
SF-268 GI50
4.28 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human SF268 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SF268 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
SF-295 GI50
0.0104 μM
Compound: 7, mono-7
Cytotoxicity against human SF295 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SF295 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
SF-295 GI50
10.4 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human SF295 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SF295 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
SF-539 GI50
0.0078 μM
Compound: 7, mono-7
Cytotoxicity against human SF539 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SF539 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
SF-539 GI50
7.8 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human SF539 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SF539 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
SK-MEL-28 GI50
0.0231 μM
Compound: 7, mono-7
Cytotoxicity against human SK-MEL-28 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SK-MEL-28 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
SK-MEL-28 GI50
23.1 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human SK-MEL-28 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SK-MEL-28 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
SK-MEL-5 GI50
0.00544 μM
Compound: 7, mono-7
Cytotoxicity against human SK-MEL-5 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SK-MEL-5 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
SK-MEL-5 GI50
5.44 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human SK-MEL-5 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SK-MEL-5 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
SK-OV-3 GI50
0.0222 μM
Compound: 7, mono-7
Cytotoxicity against human SKOV3 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SKOV3 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
SK-OV-3 GI50
22.2 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human SKOV3 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SKOV3 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
SN12C GI50
0.00361 μM
Compound: 7, mono-7
Cytotoxicity against human SN12C cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SN12C cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
SN12C GI50
3.61 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human SN12C cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SN12C cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
SNB-19 GI50
0.0375 μM
Compound: 7, mono-7
Cytotoxicity against human SNB19 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SNB19 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
SNB-19 GI50
37.5 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human SNB19 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SNB19 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
SNB-75 GI50
0.0149 μM
Compound: 7, mono-7
Cytotoxicity against human SNB75 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SNB75 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
SNB-75 GI50
14.9 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human SNB75 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SNB75 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
SR GI50
0.00225 μM
Compound: 7, mono-7
Cytotoxicity against human SR cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SR cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
SR GI50
2.25 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human SR cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SR cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
SW-620 GI50
0.0111 μM
Compound: 7, mono-7
Cytotoxicity against human SW620 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SW620 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
SW-620 GI50
11.1 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human SW620 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SW620 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
T47D GI50
0.021 μM
Compound: 7, mono-7
Cytotoxicity against human T47D cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human T47D cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
T47D GI50
20.6 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human T47D cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human T47D cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
TK-10 GI50
0.00375 μM
Compound: 7, mono-7
Cytotoxicity against human TK10 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human TK10 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
TK-10 GI50
3.75 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human TK10 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human TK10 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
U-251 GI50
0.00257 μM
Compound: 7, mono-7
Cytotoxicity against human U251 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human U251 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
U-251 GI50
12.7 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human U251 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human U251 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
UACC-257 GI50
0.0196 μM
Compound: 7, mono-7
Cytotoxicity against human UACC257 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human UACC257 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
UACC-257 GI50
19.6 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human UACC257 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human UACC257 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
UACC-62 GI50
0.0127 μM
Compound: 7, mono-7
Cytotoxicity against human UACC62 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human UACC62 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
UACC-62 GI50
12.7 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human UACC62 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human UACC62 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
UO-31 GI50
0.00515 μM
Compound: 7, mono-7
Cytotoxicity against human UO31 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human UO31 cells after 48 hrs by sulforhodamine B assay
[PMID: 21660118]
UO-31 GI50
5.15 nM
Compound: 9, C5'-Me 9
Cytotoxicity against human UO31 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human UO31 cells after 48 hrs by sulforhodamine B assay
[PMID: 21572583]
分子量

488.66

Formula

C29H44O6

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
HOE 689
目录号:
HY-164033
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