HOE 689 (Synonyms: Ramnodigin)

目录号: HY-164033: FAQs
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HOE 689 (Ramnodigin) 是 Digitoxin (HY-B1357) 的类似物。HOE 689 对肺癌细胞表现出细胞毒性，诱导 NCI-H460 细胞凋亡 (apoptosis)，IC₅₀ 为 52 nM。

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HOE 689 Chemical Structure

CAS No. : 33156-28-4

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生物活性
纯度 & 产品资料
参考文献

生物活性

HOE 689 (Ramnodigin) is an analog of Digitoxin (HY-B1357). HOE 689 exhibits cytotoxicity to lung cancer cells and induces apoptosis in cancer cell NCI-H460 with an IC₅₀ of 52 nM^[1].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
786-0	GI₅₀	0.00621 μM Compound: 7, mono-7	Cytotoxicity against human 786-0 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human 786-0 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
786-0	GI₅₀	6.21 nM Compound: 9, C5'-Me 9	Cytotoxicity against human 786-0 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human 786-0 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
A498	GI₅₀	0.0207 μM Compound: 7, mono-7	Cytotoxicity against human A498 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human A498 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
A498	GI₅₀	20.7 nM Compound: 9, C5'-Me 9	Cytotoxicity against human A498 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human A498 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
A549	GI₅₀	0.00156 μM Compound: 7, mono-7	Cytotoxicity against human A549 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human A549 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
A549	GI₅₀	1.56 nM Compound: 9, C5'-Me 9	Cytotoxicity against human A549/ATCC cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human A549/ATCC cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
ACHN	GI₅₀	0.00431 μM Compound: 7, mono-7	Cytotoxicity against human ACHN cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human ACHN cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
ACHN	GI₅₀	4.31 nM Compound: 9, C5'-Me 9	Cytotoxicity against human ACHN cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human ACHN cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
BT-549	GI₅₀	2.41 nM Compound: 9, C5'-Me 9	Cytotoxicity against human BT549 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human BT549 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
CAKI-1	GI₅₀	3.32 nM Compound: 9, C5'-Me 9	Cytotoxicity against human Caki1 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human Caki1 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
CCRF-CEM	GI₅₀	8.49 nM Compound: 9, C5'-Me 9	Cytotoxicity against human CCRF-CEM cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human CCRF-CEM cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
COLO 205	GI₅₀	0.0296 μM Compound: 7, mono-7	Cytotoxicity against human COLO205 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human COLO205 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
COLO 205	GI₅₀	29.6 nM Compound: 9, C5'-Me 9	Cytotoxicity against human COLO205 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human COLO205 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
DU-145	GI₅₀	0.00345 μM Compound: 7, mono-7	Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
DU-145	GI₅₀	3.45 nM Compound: 9, C5'-Me 9	Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
EKVX	GI₅₀	0.00513 μM Compound: 7, mono-7	Cytotoxicity against human EKVX cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human EKVX cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
EKVX	GI₅₀	5.13 nM Compound: 9, C5'-Me 9	Cytotoxicity against human EKVX cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human EKVX cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
HCC 2998	GI₅₀	16.5 nM Compound: 9, C5'-Me 9	Cytotoxicity against human HCC2998 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human HCC2998 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
HCT-15	GI₅₀	0.0205 μM Compound: 7, mono-7	Cytotoxicity against human HCT15 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human HCT15 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
HCT-15	GI₅₀	20.5 nM Compound: 9, C5'-Me 9	Cytotoxicity against human HCT15 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human HCT15 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
HFF	CC₅₀	0.7 μM Compound: 6, alpha-L-Amip-Dig	Cytotoxicity against HFF assessed as inhibition of cell viability after 3 days by MTT assay Cytotoxicity against HFF assessed as inhibition of cell viability after 3 days by MTT assay	[PMID: 24900847]
HFF	CC₅₀	4 μM Compound: 6, alpha-L-Amip-Dig	Cytotoxicity against HFF assessed as inhibition of cell viability after 3 days by trypan blue exclusion assay Cytotoxicity against HFF assessed as inhibition of cell viability after 3 days by trypan blue exclusion assay	[PMID: 24900847]
HL-60(TB)	GI₅₀	2.96 nM Compound: 9, C5'-Me 9	Cytotoxicity against human HL-60(TB) cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human HL-60(TB) cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
HOP-62	GI₅₀	0.00855 μM Compound: 7, mono-7	Cytotoxicity against human HOP62 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human HOP62 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
HOP-62	GI₅₀	8.55 nM Compound: 9, C5'-Me 9	Cytotoxicity against human HOP62 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human HOP62 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
HOP-92	GI₅₀	0.0113 μM Compound: 7, mono-7	Cytotoxicity against human HOP92 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human HOP92 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
HOP-92	GI₅₀	11.3 nM Compound: 9, C5'-Me 9	Cytotoxicity against human HOP92 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human HOP92 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
Hs-578T	GI₅₀	0.00457 μM Compound: 7, mono-7	Cytotoxicity against human Hs578T cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human Hs578T cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
Hs-578T	GI₅₀	4.57 nM Compound: 9, C5'-Me 9	Cytotoxicity against human Hs578T cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human Hs578T cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
HT-29	GI₅₀	0.0119 μM Compound: 7, mono-7	Cytotoxicity against human HT-29 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human HT-29 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
HT-29	GI₅₀	11.9 nM Compound: 9, C5'-Me 9	Cytotoxicity against human HT-29 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human HT-29 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
IGROV-1	GI₅₀	5.23 nM Compound: 9, C5'-Me 9	Cytotoxicity against human IGROV1 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human IGROV1 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
K562	GI₅₀	19.5 nM Compound: 9, C5'-Me 9	Cytotoxicity against human K562 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human K562 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
KM12	GI₅₀	0.0324 μM Compound: 7, mono-7	Cytotoxicity against human KM12 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human KM12 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
KM12	GI₅₀	32.4 nM Compound: 9, C5'-Me 9	Cytotoxicity against human KM12 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human KM12 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
LOX IMVI	GI₅₀	0.0118 μM Compound: 7, mono-7	Cytotoxicity against human LOXIMVI cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human LOXIMVI cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
LOX IMVI	GI₅₀	11.8 nM Compound: 9, C5'-Me 9	Cytotoxicity against human LOXIMVI cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human LOXIMVI cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
M14	GI₅₀	0.0193 μM Compound: 7, mono-7	Cytotoxicity against human M14 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human M14 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
M14	GI₅₀	19.3 nM Compound: 9, C5'-Me 9	Cytotoxicity against human M14 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human M14 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
Malme-3M	GI₅₀	0.0183 μM Compound: 7, mono-7	Cytotoxicity against human MALME-3M cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human MALME-3M cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
Malme-3M	GI₅₀	18.3 nM Compound: 9, C5'-Me 9	Cytotoxicity against human MALME-3M cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human MALME-3M cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
MCF7	GI₅₀	0.00589 μM Compound: 7, mono-7	Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
MCF7	GI₅₀	5.89 nM Compound: 9, C5'-Me 9	Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
MDA-MB-231	GI₅₀	0.0339 μM Compound: 7, mono-7	Cytotoxicity against human MDA-MB-231 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human MDA-MB-231 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
MDA-MB-231	GI₅₀	33.9 nM Compound: 9, C5'-Me 9	Cytotoxicity against human MDA-MB-231 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human MDA-MB-231 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
MDA-MB-435	GI₅₀	0.0277 μM Compound: 7, mono-7	Cytotoxicity against human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
MDA-MB-435	GI₅₀	21 nM Compound: 9, C5'-Me 9	Cytotoxicity against human MDA-MB-435 breast cancer cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human MDA-MB-435 breast cancer cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
MDA-MB-435	GI₅₀	27.7 nM Compound: 9, C5'-Me 9	Cytotoxicity against human MDA-MB-435 melanoma cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human MDA-MB-435 melanoma cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
MOLT-4	GI₅₀	0.00257 μM Compound: 7, mono-7	Cytotoxicity against human MOLT4 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human MOLT4 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
MOLT-4	GI₅₀	2.57 nM Compound: 9, C5'-Me 9	Cytotoxicity against human MOLT4 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human MOLT4 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
NCI/ADR-RES	GI₅₀	4.12 nM Compound: 9, C5'-Me 9	Cytotoxicity against human NCI/ADR-RES cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human NCI/ADR-RES cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
NCI-H226	GI₅₀	0.0193 μM Compound: 7, mono-7	Cytotoxicity against human NCI-H226 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human NCI-H226 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
NCI-H226	GI₅₀	19.3 nM Compound: 9, C5'-Me 9	Cytotoxicity against human NCI-H226 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human NCI-H226 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
NCI-H23	GI₅₀	0.00413 μM Compound: 7, mono-7	Cytotoxicity against human NCI-H23 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human NCI-H23 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
NCI-H23	GI₅₀	4.13 nM Compound: 9, C5'-Me 9	Cytotoxicity against human NCI-H23 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human NCI-H23 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
NCI-H322M	GI₅₀	0.00778 μM Compound: 7, mono-7	Cytotoxicity against human NCI-H322M cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human NCI-H322M cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
NCI-H322M	GI₅₀	7.78 nM Compound: 9, C5'-Me 9	Cytotoxicity against human NCI-H322M cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human NCI-H322M cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
NCI-H460	GI₅₀	0.00383 μM Compound: 7, mono-7	Cytotoxicity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
NCI-H460	GI₅₀	1.927 nM Compound: 9, C5'-Me 9	Cytotoxicity against human NCI-H460 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against human NCI-H460 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 21572583]
NCI-H460	GI₅₀	2 nM Compound: 9, C5'-Me 9	Growth inhibition of human NCI-H460 cells after 48 hrs by MTT assay Growth inhibition of human NCI-H460 cells after 48 hrs by MTT assay	[PMID: 21572583]
NCI-H460	GI₅₀	2.2 nM Compound: 7,alpha-L-amicetose	Growth inhibition of human NCI-H460 cells after 48 hrs by MTT assay Growth inhibition of human NCI-H460 cells after 48 hrs by MTT assay	[PMID: 21643465]
NCI-H460	GI₅₀	3.83 nM Compound: 9, C5'-Me 9	Cytotoxicity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
NCI-H460	IC₅₀	47.98 nM Compound: 7, mono-7	Cytotoxicity against human NCI-H460 cell assessed as cell death after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy Cytotoxicity against human NCI-H460 cell assessed as cell death after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy	[PMID: 21660118]
NCI-H460	IC₅₀	51.73 nM Compound: 9, C5'-Me 9	Induction of apoptosis in human NCI-H460 cells in serum free medium after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy Induction of apoptosis in human NCI-H460 cells in serum free medium after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy	[PMID: 21572583]
NCI-H460	IC₅₀	52 nM Compound: 9, C5'-Me 9	Cytotoxicity in human NCI-H460 cells in serum free medium at 50 nM after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy Cytotoxicity in human NCI-H460 cells in serum free medium at 50 nM after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy	[PMID: 21572583]
NCI-H460	IC₅₀	55.7 nM Compound: 7,alpha-L-amicetose	Cytotoxicity against human NCI-H460 cells assessed as cell death at 50 nM after 12 hrs by Hoechst-33342 staining and propidium iodide staining Cytotoxicity against human NCI-H460 cells assessed as cell death at 50 nM after 12 hrs by Hoechst-33342 staining and propidium iodide staining	[PMID: 21643465]
NCI-H522	GI₅₀	0.00938 μM Compound: 7, mono-7	Cytotoxicity against human NCI-H522 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human NCI-H522 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
NCI-H522	GI₅₀	9.38 nM Compound: 9, C5'-Me 9	Cytotoxicity against human NCI-H522 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human NCI-H522 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
OVCAR-3	GI₅₀	0.00494 μM Compound: 7, mono-7	Cytotoxicity against human OVCAR3 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human OVCAR3 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
OVCAR-3	GI₅₀	4.94 nM Compound: 9, C5'-Me 9	Cytotoxicity against human OVCAR3 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human OVCAR3 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
OVCAR-4	GI₅₀	0.0189 μM Compound: 7, mono-7	Cytotoxicity against human OVCAR4 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human OVCAR4 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
OVCAR-4	GI₅₀	18.9 nM Compound: 9, C5'-Me 9	Cytotoxicity against human OVCAR4 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human OVCAR4 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
OVCAR-5	GI₅₀	17.4 nM Compound: 9, C5'-Me 9	Cytotoxicity against human OVCAR5 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human OVCAR5 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
OVCAR-8	GI₅₀	0.0025 μM Compound: 7, mono-7	Cytotoxicity against human OVCAR8 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human OVCAR8 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
OVCAR-8	GI₅₀	2.5 nM Compound: 9, C5'-Me 9	Cytotoxicity against human OVCAR8 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human OVCAR8 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
PC-3	GI₅₀	0.00955 μM Compound: 7, mono-7	Cytotoxicity against human PC3 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human PC3 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
PC-3	GI₅₀	9.55 nM Compound: 9, C5'-Me 9	Cytotoxicity against human PC3 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human PC3 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
RPMI-8226	GI₅₀	0.0235 μM Compound: 7, mono-7	Cytotoxicity against human RPMI8226 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human RPMI8226 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
RPMI-8226	GI₅₀	23.5 nM Compound: 9, C5'-Me 9	Cytotoxicity against human RPMI8226 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human RPMI8226 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
RXF 393	GI₅₀	1.22 nM Compound: 9, C5'-Me 9	Cytotoxicity against human RXF393 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human RXF393 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
SF-268	GI₅₀	0.00428 μM Compound: 7, mono-7	Cytotoxicity against human SF268 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SF268 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
SF-268	GI₅₀	4.28 nM Compound: 9, C5'-Me 9	Cytotoxicity against human SF268 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SF268 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
SF-295	GI₅₀	0.0104 μM Compound: 7, mono-7	Cytotoxicity against human SF295 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SF295 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
SF-295	GI₅₀	10.4 nM Compound: 9, C5'-Me 9	Cytotoxicity against human SF295 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SF295 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
SF-539	GI₅₀	0.0078 μM Compound: 7, mono-7	Cytotoxicity against human SF539 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SF539 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
SF-539	GI₅₀	7.8 nM Compound: 9, C5'-Me 9	Cytotoxicity against human SF539 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SF539 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
SK-MEL-28	GI₅₀	0.0231 μM Compound: 7, mono-7	Cytotoxicity against human SK-MEL-28 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SK-MEL-28 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
SK-MEL-28	GI₅₀	23.1 nM Compound: 9, C5'-Me 9	Cytotoxicity against human SK-MEL-28 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SK-MEL-28 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
SK-MEL-5	GI₅₀	0.00544 μM Compound: 7, mono-7	Cytotoxicity against human SK-MEL-5 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SK-MEL-5 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
SK-MEL-5	GI₅₀	5.44 nM Compound: 9, C5'-Me 9	Cytotoxicity against human SK-MEL-5 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SK-MEL-5 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
SK-OV-3	GI₅₀	0.0222 μM Compound: 7, mono-7	Cytotoxicity against human SKOV3 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SKOV3 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
SK-OV-3	GI₅₀	22.2 nM Compound: 9, C5'-Me 9	Cytotoxicity against human SKOV3 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SKOV3 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
SN12C	GI₅₀	0.00361 μM Compound: 7, mono-7	Cytotoxicity against human SN12C cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SN12C cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
SN12C	GI₅₀	3.61 nM Compound: 9, C5'-Me 9	Cytotoxicity against human SN12C cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SN12C cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
SNB-19	GI₅₀	0.0375 μM Compound: 7, mono-7	Cytotoxicity against human SNB19 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SNB19 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
SNB-19	GI₅₀	37.5 nM Compound: 9, C5'-Me 9	Cytotoxicity against human SNB19 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SNB19 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
SNB-75	GI₅₀	0.0149 μM Compound: 7, mono-7	Cytotoxicity against human SNB75 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SNB75 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
SNB-75	GI₅₀	14.9 nM Compound: 9, C5'-Me 9	Cytotoxicity against human SNB75 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SNB75 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
SR	GI₅₀	0.00225 μM Compound: 7, mono-7	Cytotoxicity against human SR cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SR cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
SR	GI₅₀	2.25 nM Compound: 9, C5'-Me 9	Cytotoxicity against human SR cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SR cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
SW-620	GI₅₀	0.0111 μM Compound: 7, mono-7	Cytotoxicity against human SW620 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SW620 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
SW-620	GI₅₀	11.1 nM Compound: 9, C5'-Me 9	Cytotoxicity against human SW620 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SW620 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
T47D	GI₅₀	0.021 μM Compound: 7, mono-7	Cytotoxicity against human T47D cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human T47D cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
T47D	GI₅₀	20.6 nM Compound: 9, C5'-Me 9	Cytotoxicity against human T47D cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human T47D cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
TK-10	GI₅₀	0.00375 μM Compound: 7, mono-7	Cytotoxicity against human TK10 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human TK10 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
TK-10	GI₅₀	3.75 nM Compound: 9, C5'-Me 9	Cytotoxicity against human TK10 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human TK10 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
U-251	GI₅₀	0.00257 μM Compound: 7, mono-7	Cytotoxicity against human U251 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human U251 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
U-251	GI₅₀	12.7 nM Compound: 9, C5'-Me 9	Cytotoxicity against human U251 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human U251 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
UACC-257	GI₅₀	0.0196 μM Compound: 7, mono-7	Cytotoxicity against human UACC257 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human UACC257 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
UACC-257	GI₅₀	19.6 nM Compound: 9, C5'-Me 9	Cytotoxicity against human UACC257 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human UACC257 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
UACC-62	GI₅₀	0.0127 μM Compound: 7, mono-7	Cytotoxicity against human UACC62 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human UACC62 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
UACC-62	GI₅₀	12.7 nM Compound: 9, C5'-Me 9	Cytotoxicity against human UACC62 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human UACC62 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
UO-31	GI₅₀	0.00515 μM Compound: 7, mono-7	Cytotoxicity against human UO31 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human UO31 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
UO-31	GI₅₀	5.15 nM Compound: 9, C5'-Me 9	Cytotoxicity against human UO31 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human UO31 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]

分子量

488.66

Formula

C₂₉H₄₄O₆

CAS 号

33156-28-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

产品使用指南 (1538 KB)

参考文献

[1]. Wang HY, et al., C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity. ACS Med Chem Lett. 2011 Apr 14;2(4):259-263. [Content Brief]

HOE 689 相关分类

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HOE 68933156-28-4RamnodiginHOE689HOE-689ApoptosisNCI-H460DigitoxinrhamnoseamicetoseInhibitorinhibitorinhibit

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HOE 689 (Synonyms: Ramnodigin)

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HOE 689 (Synonyms: Ramnodigin)

HOE 689 相关抗体

HOE 689 相关产品

•同靶点产品:

•同靶点蛋白产品:

生物活性

纯度 & 产品资料

参考文献

HOE 689 相关分类

摩尔计算器

稀释计算器

The molarity calculator equation

The dilution calculator equation

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您最近查看的产品:

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