2. Anti-infection
  3. SARS-CoV
  4. Ipomoeassin F

Ipomoeassin F 是一种有效的、选择性内质网 (ER) 蛋白易位抑制剂，通过靶向 ER 膜上的 Sec61 复合物 (Sec61α) 的成孔亚基。Ipomoeassin F 选择性抑制 SARS-CoV-2 蛋白的 ER 膜转位。Ipomoeassin F 阻断分泌蛋白和 I 型跨膜蛋白 (TMP) 的内质网易位，但不阻断 III 型 TMP。

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Ipomoeassin F Chemical Structure

Ipomoeassin F Chemical Structure

CAS No. : 915392-44-8

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Ipomoeassin F 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ipomoeassin F is a potent and selective endoplasmic reticulum (ER) protein-translocation inhibitor by targeting the pore-forming subunit of the Sec61 complex (Sec61α) at the ER membrane. Ipomoeassin F selectively inhibits the ER membrane translocation of SARS-CoV-2 proteins. Ipomoeassin F block the ER translocation of secretory proteins and type I transmembrane proteins (TMPs), but not type III TMPs[1][2][3].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A2780 IC50
36 nM
Compound: Ipomoeassin F
Cytotoxicity against human A2780 cells after 72 hrs
Cytotoxicity against human A2780 cells after 72 hrs
[PMID: 29291442]
HeLa IC50
16.4 nM
Compound: 188
Cytotoxicity against human HeLa cells assessed as cell growth inhibition incubated for 3 days by MTT assay
Cytotoxicity against human HeLa cells assessed as cell growth inhibition incubated for 3 days by MTT assay
[PMID: 29126728]
HT-29 IC50
4.2 nM
Compound: Ipomoeassin F
Cytotoxicity against human HT-29 cells after 72 hrs
Cytotoxicity against human HT-29 cells after 72 hrs
[PMID: 29291442]
Jurkat IC50
6.1 nM
Compound: 188
Cytotoxicity against human Jurkat cells assessed as cell growth inhibition incubated for 3 days by MTT assay
Cytotoxicity against human Jurkat cells assessed as cell growth inhibition incubated for 3 days by MTT assay
[PMID: 29126728]
L929 IC50
7.4 nM
Compound: Ipomoeassin F
Cytotoxicity against mouse L929 cells after 72 hrs
Cytotoxicity against mouse L929 cells after 72 hrs
[PMID: 29291442]
MCF-10A IC50
5.1 nM
Compound: Ipomoeassin F
Cytotoxicity against human MCF10A cells assessed as reduction in cell viability after 72 hrs by Alamar Blue assay
Cytotoxicity against human MCF10A cells assessed as reduction in cell viability after 72 hrs by Alamar Blue assay
[PMID: 29291442]
MCF-10A IC50
5.4 nM
Compound: 188
Cytotoxicity against human MCF-10A cells assessed as cell growth inhibition incubated for 3 days by MTT assay
Cytotoxicity against human MCF-10A cells assessed as cell growth inhibition incubated for 3 days by MTT assay
[PMID: 29126728]
MCF7 IC50
36.4 nM
Compound: Ipomoeassin F
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 29291442]
MCF7 IC50
43.7 nM
Compound: 188
Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 3 days by MTT assay
Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 3 days by MTT assay
[PMID: 29126728]
MCF7 IC50
43.7 nM
Compound: Ipomoeassin F
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 28465102]
MDA-MB-231 IC50
6.5 nM
Compound: 188
Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 3 days by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 3 days by MTT assay
[PMID: 29126728]
MDA-MB-231 IC50
6.5 nM
Compound: Ipomoeassin F
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by alamarBlue assay
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by alamarBlue assay
[PMID: 28465102]
MDA-MB-231 IC50
7.7 nM
Compound: Ipomoeassin F
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by Alamar Blue assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by Alamar Blue assay
[PMID: 29291442]
MDA-MB-435 IC50
9.4 nM
Compound: Ipomoeassin F
Cytotoxicity against human MDA-MB-435 cells after 72 hrs
Cytotoxicity against human MDA-MB-435 cells after 72 hrs
[PMID: 29291442]
NIH3T3 IC50
16.8 nM
Compound: 188
Cytotoxicity against mouse NIH/3T3 cells assessed as cell growth inhibition incubated for 3 days by MTT assay
Cytotoxicity against mouse NIH/3T3 cells assessed as cell growth inhibition incubated for 3 days by MTT assay
[PMID: 29126728]
Panel NCI-60 cells GI50
30 nM
Compound: Ipomoeassin F
Growth inhibition of human NCI60 cells after 48 hrs by SRB assay
Growth inhibition of human NCI60 cells after 48 hrs by SRB assay
[PMID: 29291442]
U-937 IC50
2.6 nM
Compound: Ipomoeassin F
Cytotoxicity against human U937 cells after 72 hrs
Cytotoxicity against human U937 cells after 72 hrs
[PMID: 29291442]
U-937 IC50
5.4 nM
Compound: 188
Cytotoxicity against human U-937 cells assessed as cell growth inhibition incubated for 3 days by MTT assay
Cytotoxicity against human U-937 cells assessed as cell growth inhibition incubated for 3 days by MTT assay
[PMID: 29126728]
体外研究
(In Vitro)

Ipomoeassin F (1-500 nM; 24 小时) 有效抑制 α1AT 易位到 ER[1]。
Ipomoeassin F 在人卵巢癌细胞系 A2780 中具有很强的活性，IC50 值为 0.036 μM[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ipomoeassin F 相关抗体:

Western Blot Analysis[1]

Cell Line: HepG2 cells
Concentration: 1, 5, 10, 25, 50, 75, 100, 250, 500 nM
Incubation Time: 24 h
Result: Downregulated cellular ATP levels and inhibited Sec61-mediated protein translocation with comparable potency.
分子量

830.95

Formula

C44H62O15
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ipomoeassin F 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ipomoeassin F915392-44-8Ipom-FSARS-CoVSARS coronavirusendoplasmic reticulumERprotein-translocationSec61Sec61αSARS-CoV-2secretory proteintransmembrane proteinsTMPInhibitorinhibitorinhibit

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