2. 天然产物
  3. 植物 萜类
  4. 葫芦科 三萜
  5. Cucumis prophetarum L.
  6. Isocucurbitacin D

Isocucurbitacin D 是一种抗癌剂。

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Isocucurbitacin D Chemical Structure

Isocucurbitacin D Chemical Structure

CAS No. : 68422-20-8

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Isocucurbitacin D 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Isocucurbitacin D is an antitumor agent[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HepG2 EC50
13.8 μM
Compound: 4
Hepatoprotective activity in human HepG2 cells assessed as inhibition of CCl4-induced toxicity after 24 hrs by MTT assay
Hepatoprotective activity in human HepG2 cells assessed as inhibition of CCl4-induced toxicity after 24 hrs by MTT assay
[PMID: 21459003]
HepG2 IC50
80.33 μM
Compound: 4
Cytotoxicity against human HepG2 cells after 24 hrs assessed as inhibition of cell viability by MTT assay
Cytotoxicity against human HepG2 cells after 24 hrs assessed as inhibition of cell viability by MTT assay
[PMID: 21459003]
HSC-T6 EC50
0.06 μM
Compound: 4
Antiproliferative activity against serum-stimulated rat HSC-T6 cells after 24 hrs by MTT assay
Antiproliferative activity against serum-stimulated rat HSC-T6 cells after 24 hrs by MTT assay
[PMID: 21459003]
HSC-T6 IC50
8.7 μM
Compound: 4
Cytotoxicity against rat HSC-T6 cell after 24 hrs by MTT assay
Cytotoxicity against rat HSC-T6 cell after 24 hrs by MTT assay
[PMID: 21459003]
体外研究
(In Vitro)

Isocucurbitacin D inhibits tumor cell growth with ED50s of 0.06, 0.2, 0.6, 0.8 and 1.2 μg/mL against SK-MEL-2, A549, XF498, HCT15 and SK-OV-3 cells, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Isocucurbitacin D 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MCF-7, MDA MB 231, A2780, A2780 CP, HepG2 and HCT-116 cells
Concentration: 0-100 μM
Incubation Time: 48 h
Result: Inhibited cell proliferation with IC50s of 12.0, 30.7, 37.8, 47.9, >100 and >100 μM against MDA MB 231, HCT-116, HepG2, MCF-7, A2780 and A2780 CP, respectively.
分子量

516.67

Formula

C30H44O7
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Isocucurbitacin D 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isocucurbitacin D68422-20-8OthersSK-MEL-2A549XF498HCT15SK-OV-3Inhibitorinhibitorinhibit

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