2. Metabolic Enzyme/Protease
  3. 5 alpha Reductase
  4. Izonsteride

Izonsteride (Compound LY320236) 是 5α-还原酶 (5α-reductase) 的抑制剂 (IC50=11.6 nM (type I); 7.37 nM (type II))。LY320236 通过抑制甾体 5α-还原酶活性，阻止睾酮 (T) 转化为二氢睾酮 (DHT)。LY320236 能够显著抑制 LNCaP 肿瘤在胸腺小鼠中的生长，且未出现明显的宿主毒性。

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Izonsteride Chemical Structure

Izonsteride Chemical Structure

CAS No. : 176975-26-1

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Izonsteride 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Izonsteride (Compound LY320236) is an inhibitor of 5α-reductase (IC50 = 11.6 nM for type I; 7.37 nM for type II). LY320236 inhibits the activity of steroid 5α-reductase, preventing the conversion of testosterone (T) to dihydrotestosterone (DHT). LY320236 can significantly inhibit the growth of LNCaP tumors in thymic mice without exhibiting obvious host toxicity[1].

分子量

422.61

Formula

C24H26N2OS2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Izonsteride 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Izonsteride176975-26-1LY 320236LY320236LY-3202365 alpha Reductase5α-reductaseSteroid 5α- reductaseInhibition of testosterone conversionLNCaPInhibitorinhibitorinhibit

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