2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Apoptosis
  3. HSP Apoptosis
  4. JG-98

JG-98 是一种热休克蛋白 70 (Hsp70) 变构抑制剂，可与 Hsp70 上的保守位点紧密结合，打断 Hsp70-Bag3 相互作用。JG-98 影响癌细胞和肿瘤相关巨噬细胞，显示抗癌活性。

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JG-98 Chemical Structure

JG-98 Chemical Structure

CAS No. : 1456551-16-8

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1 mg ￥1333
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5 mg ￥3163
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10 mg ￥3800
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Customer Review

JG-98 相关抗体

Top Publications Citing Use of Products

    JG-98 purchased from MCE. Usage Cited in: Sci Rep. 2019 Oct 7;9(1):14394.  [Abstract]

    Western blot analysis of activated caspase-3 and cleaved PARP in cells non-treated and treated with JG-98 or VER (72 h). Representative immunoblots are shown (n = 2), actin is used as a protein loading control.

    查看 HSP 亚型特异性产品:

    查看所有亚型
    HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction. JG-98 shows anti-cancer activities affecting both cancer cells and tumor-associated macrophages[1][2][3].

    IC50 & Target

    Heat shock protein 70[1]
    细胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    MCF7 EC50
    0.7 μM
    Compound: 30, JG-98
    Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 24312699]
    MCF7 IC50
    0.71 μM
    Compound: JG-98
    Antiproliferative activity against human MCF7 cells by MTT assay
    Antiproliferative activity against human MCF7 cells by MTT assay
    		[PMID: 29953808]
    MDA-MB-231 IC50
    0.39 μM
    Compound: JG-98
    Antiproliferative activity against human MDA-MB-231 cells by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells by MTT assay
    		[PMID: 29953808]
    MDA-MB-231 EC50
    0.4 μM
    Compound: 30, JG-98
    Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 24312699]
    MEF EC50
    24 μM
    Compound: 30, JG-98
    Cytotoxicity against C57BL/6 mouse MEF assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against C57BL/6 mouse MEF assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 24312699]
    MEF IC50
    4.2 μM
    Compound: JG-98
    Antiproliferative activity against MEF cells by MTT assay
    Antiproliferative activity against MEF cells by MTT assay
    		[PMID: 29953808]
    体外研究
    (In Vitro)

    JG-98 (30 nM-30 μM; 72 hours) has antiproliferative activity across a range of cell lines with the EC50s between ~0.3 and 4 μM[2].
    JG-98 (10 μM; 48 hours) activates apoptotic mediators (cleavage of caspase-3 and PARP) in MDA-MB-231 cells[1].
    JG-98 destabilizes FoxM1 and relieves suppression of downstream effectors, including p21 and p27[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    JG-98 相关抗体:

    Cell Proliferation Assay[2]

    Cell Line: MCF-7, MDA-MB-231, A375, MeWo, HeLa, HT-29, SKOV3, Jurkat, mouse embryonic fibroblasts (MEF), MM1.R, INA6, RPMI-8226, JJN-3, U266, NCI-H929, L363, MM1.S, KMS11, LP-1, AMO-1, OPM1, OPM2 cells
    Concentration: 30 nM-30 μM
    Incubation Time: 72 hours
    Result: Active against all of the lines tested, and the EC50s were variable (between ~0.3 μM and 4 μM). Normal MEFs and OPM1 and OPM2 were relatively less sensitive.

    Western Blot Analysis[1]

    Cell Line: MDA-MB-231 cells
    Concentration: 10 μM
    Incubation Time: 48 hours
    Result: Incudes apoptotic mediators cleavage of caspase 3 and PARP.
    体内研究
    (In Vivo)

    JG-98 (3 mg/kg; i.p.; on days 0, 2, and 4) suppresses tumor growth in xenograft models bearing MCF7 and HeLa cells[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: 6-week-old NCR mice (xenografts of MCF7 and HeLa cells)[2]
    Dosage: 3 mg/kg
    Administration: Intraperitoneal injection; on days 0, 2, and 4
    Result: Limited tumor growth, but somewhat less effectively.
    分子量

    534.54

    Formula

    C24H21Cl2N3OS3
    CAS 号
    性状

    固体

    颜色

    Yellow to orange

    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    溶解性数据
    细胞实验： 

    DMSO 中的溶解度 : 5 mg/mL (9.35 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 1.8708 mL 9.3538 mL 18.7077 mL
    5 mM 0.3742 mL 1.8708 mL 3.7415 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    纯度 & 产品资料

    纯度: 99.88%

    COA (286 KB) LCMS (103 KB)

    产品使用指南 (1538 KB)
    参考文献

    JG-98 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.8708 mL 9.3538 mL 18.7077 mL 46.7692 mL
    5 mM 0.3742 mL 1.8708 mL 3.7415 mL 9.3538 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    JG-981456551-16-8JG98JG 98HSPApoptosisHeat shock proteinsInhibitorinhibitorinhibit

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    产品名称：
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    目录号：
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