2. Epigenetics Cell Cycle/DNA Damage Apoptosis
  3. Histone Demethylase CDK Apoptosis Caspase
  4. KDM1/CDK1-IN-1

KDM1/CDK1-IN-1 (compound 4) 是一种有效的 KDM1 和 CDK1 抑制剂，IC50 值分别为 0.096 和 0.078 μM。KDM1/CDK1-IN-1 诱导 HOP-92 细胞周期阻滞在 G2/M 期并诱导凋亡 (apoptosis)。KDM1/CDK1-IN-1 对 CCRF-CEM、HOP-92 和 Hep-G2 细胞表现出较强的细胞毒性活性，IC50 分别为 16.34、3.45 和 7.79 μM。

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KDM1/CDK1-IN-1 Chemical Structure

KDM1/CDK1-IN-1 Chemical Structure

CAS No. : 2938990-92-0

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KDM1/CDK1-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Histone Demethylase 亚型特异性产品:

查看所有亚型
KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6

查看 CDK 亚型特异性产品:

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

查看 Caspase 亚型特异性产品:

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KDM1/CDK1-IN-1 (compound 4) is a potent KDM1 and CDK1 inhibitor, with IC50 values of 0.096 and 0.078 μM, respectively.KDM1/CDK1-IN-1 induces cell cycle arrest at G2/M phase and apoptosis in HOP-92 cells. KDM1/CDK1-IN-1 exhibits potent cytotoxic activity against the CCRF-CEM, HOP-92 and Hep-G2 cells, with IC50 values of 16.34, 3.45 and 7.79 μM, respectively[1].

IC50 & Target

KDM1/LSD1

 

CDK1

0.078 ± 2. μM (IC50)

Caspase-3

 

体外研究
(In Vitro)

KDM1/CDK1-IN-1 (compound 4) induces apoptosis by the activation of Caspase-3[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KDM1/CDK1-IN-1 相关抗体:
分子量

431.47

Formula

C22H17N5O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KDM1/CDK1-IN-1 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KDM1/CDK1-IN-12938990-92-0Histone DemethylaseCDKApoptosisCaspaseCyclin dependent kinasePyrazolo[1,5-a]pyrimidineBenzothiazoleCytotoxicCaspase-3antitumorHOP-92 cellsCCRF-CEMHep-G2leukemialung cancerliver cancerInhibitorinhibitorinhibit

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