2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. KVI-020

KVI-020  (Synonyms: WYE-160020)

目录号: HY-14186
产品使用指南

摩尔计算器

KVI-020 是一种口服有效和选择性的心房钾通道 Kv1.5 的阻滞剂，其 IC50 为 480 nM。KVI-020 可抑制 hERG， IC50 为 15100 nM。 KVI-020 是一种有效的抗心律失常剂 (antiarrhythmic)，可用于房颤 (AF) 的研究。

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KVI-020 Chemical Structure

KVI-020 Chemical Structure

CAS No. : 1000306-34-2

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KVI-020 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KVI-020 is an orally active, potent and selective blocker of the atrial potassium channel Kv1.5, with an IC50 of 480 nM. KVI-020 can inhibits hERG, with an IC50 of 15100 nM. KVI-020 is a potent antiarrhythmic agent, and can be used for atrial fibrillation (AF) research[1].

IC50 & Target

IC50: 480 ± 44 nM (Kv1.5), 15100 nM (hERG)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO IC50
> 30 μM
Compound: 4g, KVI-020, WYE-160020
Inhibition of Nav1.5 expressed in CHO cells by patch-clamp technique
Inhibition of Nav1.5 expressed in CHO cells by patch-clamp technique
[PMID: 19888755]
CHO IC50
> 30 μM
Compound: 4g, KVI-020, WYE-160020
Inhibition of Cav1.2 expressed in CHO cells by patch-clamp technique
Inhibition of Cav1.2 expressed in CHO cells by patch-clamp technique
[PMID: 19888755]
CHO IC50
1.41 μM
Compound: 4g, KVI-020, WYE-160020
Inhibition of Kv1.3 expressed in CHO cells by patch-clamp technique
Inhibition of Kv1.3 expressed in CHO cells by patch-clamp technique
[PMID: 19888755]
CHO IC50
2.66 μM
Compound: 4g, KVI-020, WYE-160020
Inhibition of Kv1.1 expressed in CHO cells by patch-clamp technique
Inhibition of Kv1.1 expressed in CHO cells by patch-clamp technique
[PMID: 19888755]
CHO IC50
23.4 μM
Compound: 4g, KVI-020, WYE-160020
Inhibition of Cav1.3 expressed in CHO cells by patch-clamp technique
Inhibition of Cav1.3 expressed in CHO cells by patch-clamp technique
[PMID: 19888755]
CHO IC50
3.87 μM
Compound: 4g, KVI-020, WYE-160020
Inhibition of Kv4.3 expressed in CHO cells by patch-clamp technique
Inhibition of Kv4.3 expressed in CHO cells by patch-clamp technique
[PMID: 19888755]
CHO IC50
480 nM
Compound: 4g, KVI-020, WYE-160020
Inhibition of human Kv1.5 expressed in CHO cells by patch-clamp technique
Inhibition of human Kv1.5 expressed in CHO cells by patch-clamp technique
[PMID: 19888755]
分子量

419.49

Formula

C20H25N3O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KVI-020 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KVI-0201000306-34-2WYE-160020KVI020KVI 020WYE160020WYE 160020Potassium ChannelKcsAAtrial fibrillationcardiac arrhythmiaKv1.5antiarrhythmicorally activeInhibitorinhibitorinhibit

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产品名称：
KVI-020
目录号：
HY-14186
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