1. Metabolic Enzyme/Protease
  2. Farnesyl Transferase
  3. L-778123 dihydrochloride

L-778123 dihydrochloride 是 FPTaseGGPTase-I 双重抑制剂, IC50 值分别为2 nM 和 98 nM。

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L-778123 dihydrochloride Chemical Structure

L-778123 dihydrochloride Chemical Structure

CAS No. : 183499-56-1

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L-778123 dihydrochloride 的其他形式现货产品:

Other Forms of L-778123 dihydrochloride:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

L-778123 dihydrochloride is a dual FPTase and GGPTase-I inhibitor, with IC50s of 2 nM and 98 nM, respectively[1][2].

体外研究
(In Vitro)

L-778123 dihydrochloride 单独使用对 HT-29 和 A549 细胞系没有明显的细胞毒性 (IC50: >100 μM),但可以与 Doxorubicin (HY-15142A) 产生协同作用,且 IC50s 分别降低为 1.72 和 1.52 μM[2]
L-778123 dihydrochloride 抑制骨髓性白血病细胞细胞系的增殖,IC50 值为 0.2 μM-1.8 μM,原代样品中的 IC50 值为 0.1 μM-161.8 μM[3]
L-778123 dihydrochloride (0-1 μM, 12 小时; 或 5 μM,6 小时) 抑制 HL-60 细胞中的 H-RAS 异戊二烯化,并抑制磷酸化 MEK-1/2 水平 (5 μM,24 小时)[3]
L-778123 dihydrochloride (0-100 μM,72 小时) 抑制人 PBMC 中的淋巴细胞活化 (标志物: CD71 或 CD25) 和功能[4]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

L-778123 dihydrochloride (50 mg/kg/天,输注,7 天) 抑制狗 PBMC 细胞中的 HDJ2 和 Rap1A 异戊烯化,但不抑制 Ki-Ras 异戊烯化[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

478.80

Formula

C22H22Cl3N5O

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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L-778123 dihydrochloride
目录号:
HY-16273B
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