Lipopolysaccharides, from Klebsiella pneumoniae (Synonyms: LPS, from bacterial (Klebsiella pneumoniae))

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Lipopolysaccharides, from Klebsiella pneumoniae 是一种脂多糖内毒素。Lipopolysaccharides, from Klebsiella 由三个部分组成：脂质 A、核心寡糖和 O 特异性抗原或 O 侧链。在平滑型 LPS 中，核心区域分为两个区域：靠近脂质 A 的内核和提供 O 抗原附着位点的外核。Klebsiella pneumoniae 的脂多糖在 O-3 位置可以将 l,d-HeppII 替换为α -d-半乳糖醛酸残基 (α-d-GalpA) 残基，在大多数研究的肠杆菌科 (Enterobacteriaceae) 中，核心 LPS 包含内核磷酸化修饰，但 Klebsiella pneumoniae 的核心 LPS 没有这种修饰。特殊的核心结构在 Klebsiella pneumoniae 外膜通透性和发病机制中发挥重要作用。

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Lipopolysaccharides, from Klebsiella pneumoniae Chemical Structure

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5 mg	￥2050	In-stock
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生物活性
纯度 & 产品资料
参考文献

生物活性

Lipopolysaccharides, from Klebsiella, are lipopolysaccharide endotoxins. Lipopolysaccharides, from Klebsiella pneumoniae, consist of three parts: lipid A, core oligosaccharide, and O-specific antigen or O-side chain. In smooth LPS, the core region is divided into two areas: the inner core near the lipid A and the outer core that provides attachment sites for the O-antigen. In the lipopolysaccharide of Klebsiella pneumoniae, the l,d-HeppII at the O-3 position can be replaced by an α-d-galacturonic acid residue (α-d-GalpA). In most studied Enterobacteriaceae, the core LPS contains inner core phosphorylation modifications, but the core LPS of Klebsiella pneumoniae lacks this modification. The unique core structure plays an important role in the outer membrane permeability and pathogenesis of Klebsiella pneumoniae^[1]^[2]^[3]^[4]^[5].

IC₅₀ & Target

TLR-4^[2]

性状

固体

颜色

White to off-white

中文名称

脂多糖,来源于肺炎克雷伯氏杆菌

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

细胞实验：

H₂O 中的溶解度 : 5 mg/mL (超声加热助溶)

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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体积 _(start)

浓度 _(final)

体积 _(final)

动物溶解方案计算器

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给药剂量

mg/kg

动物的平均体重

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纯度 & 产品资料

选择批次：

Data Sheet (594 KB) SDS (251 KB)

COA (255 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Kabanov DS, et al. Structural analysis of lipopolysaccharides from Gram-negative bacteria. Biochemistry (Mosc). 2010 Apr;75(4):383-404. [Content Brief]

[2]. Cai KC, et al. Age and sex differences in immune response following LPS treatment in mice. Brain Behav Immun. 2016 Nov;58:327-337. [Content Brief]

[3]. Heinrichs DE, et al. Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica. Mol Microbiol. 1998 Oct;30(2):221-32. [Content Brief]

[4]. Ying Liu, et al. Podocyte-Released Migrasomes in Urine Serve as an Indicator for Early Podocyte Injury. Kidney Dis (Basel). 2020 Nov;6(6):422-433. [Content Brief]

[5]. Izquierdo L,et al. The Klebsiella pneumoniae WabG Gene: Role InBiosynthesis of the Core Lipopolysaccharide AndVirulence[J]. Journal of bacteriology, 2003, 185(24): 7213-7221.

Lipopolysaccharides, from Klebsiella pneumoniae 相关分类

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lipopolysaccharides, from Klebsiella pneumoniaeLPS, from bacterial (Klebsiella pneumoniae)脂多糖,来源于肺炎克雷伯氏杆菌Toll-like Receptor (TLR)Inhibitorinhibitorinhibit

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Lipopolysaccharides, from Klebsiella pneumoniae (Synonyms: LPS, from bacterial (Klebsiella pneumoniae))

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Other Forms of Lipopolysaccharides, from Klebsiella pneumoniae: