Lipopolysaccharides, from Klebsiella pneumoniae (Synonyms: LPS, from bacterial (Klebsiella pneumoniae))

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Lipopolysaccharides, from Klebsiella pneumoniae 是一种脂多糖内毒素。Lipopolysaccharides, from Klebsiella 由三个部分组成：脂质 A、核心寡糖和 O 特异性抗原或 O 侧链。在平滑型 LPS 中，核心区域分为两个区域：靠近脂质 A 的内核和提供 O 抗原附着位点的外核。Klebsiella pneumoniae 的脂多糖在 O-3 位置可以将 l,d-HeppII 替换为α -d-半乳糖醛酸残基 (α-d-GalpA) 残基，在大多数研究的肠杆菌科 (Enterobacteriaceae) 中，核心 LPS 包含内核磷酸化修饰，但 Klebsiella pneumoniae 的核心 LPS 没有这种修饰。特殊的核心结构在 Klebsiella pneumoniae 外膜通透性和发病机制中发挥重要作用。

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Lipopolysaccharides, from Klebsiella pneumoniae Chemical Structure

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生物活性

Lipopolysaccharides, from Klebsiella, are lipopolysaccharide endotoxins. Lipopolysaccharides, from Klebsiella pneumoniae, consist of three parts: lipid A, core oligosaccharide, and O-specific antigen or O-side chain. In smooth LPS, the core region is divided into two areas: the inner core near the lipid A and the outer core that provides attachment sites for the O-antigen. In the lipopolysaccharide of Klebsiella pneumoniae, the l,d-HeppII at the O-3 position can be replaced by an α-d-galacturonic acid residue (α-d-GalpA). In most studied Enterobacteriaceae, the core LPS contains inner core phosphorylation modifications, but the core LPS of Klebsiella pneumoniae lacks this modification. The unique core structure plays an important role in the outer membrane permeability and pathogenesis of Klebsiella pneumoniae^[1]^[2]^[3]^[4]^[5].

IC₅₀ & Target

TLR-4^[2]

性状

固体

颜色

White to off-white

中文名称

脂多糖,来源于肺炎克雷伯氏杆菌

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Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

细胞实验：

H₂O 中的溶解度 : 5 mg/mL (超声加热助溶)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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体积 _(start)

浓度 _(final)

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Data Sheet (594 KB) SDS (251 KB)

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参考文献

[1]. Kabanov DS, et al. Structural analysis of lipopolysaccharides from Gram-negative bacteria. Biochemistry (Mosc). 2010 Apr;75(4):383-404. [Content Brief]

[2]. Cai KC, et al. Age and sex differences in immune response following LPS treatment in mice. Brain Behav Immun. 2016 Nov;58:327-337. [Content Brief]

[3]. Heinrichs DE, et al. Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica. Mol Microbiol. 1998 Oct;30(2):221-32. [Content Brief]

[4]. Ying Liu, et al. Podocyte-Released Migrasomes in Urine Serve as an Indicator for Early Podocyte Injury. Kidney Dis (Basel). 2020 Nov;6(6):422-433. [Content Brief]

[5]. Izquierdo L,et al. The Klebsiella pneumoniae WabG Gene: Role InBiosynthesis of the Core Lipopolysaccharide AndVirulence[J]. Journal of bacteriology, 2003, 185(24): 7213-7221.

Lipopolysaccharides, from Klebsiella pneumoniae 相关分类

Inflammation/Immunology

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Lipopolysaccharides, from Klebsiella pneumoniae (Synonyms: LPS, from bacterial (Klebsiella pneumoniae))

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Other Forms of Lipopolysaccharides, from Klebsiella pneumoniae:

Lipopolysaccharides, from Klebsiella pneumoniae 相关产品

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•同靶点蛋白产品:

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Lipopolysaccharides, from Klebsiella pneumoniae (Synonyms: LPS, from bacterial (Klebsiella pneumoniae))

Customer Review

Other Forms of Lipopolysaccharides, from Klebsiella pneumoniae:

Lipopolysaccharides, from Klebsiella pneumoniae 相关抗体

Lipopolysaccharides, from Klebsiella pneumoniae 相关产品

•同靶点产品:

•同靶点蛋白产品:

查看 Toll-like Receptor (TLR) 亚型特异性产品:

生物活性

纯度 & 产品资料

参考文献

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Lipopolysaccharides, from Klebsiella pneumoniae 相关分类

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