Lipopolysaccharides, from P. aeruginosa 10 (Synonyms: LPS, from Pseudomonas aeruginosa (10))

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Lipopolysaccharides from P. aeruginosa (Pseudomonas aeruginosa) 10 是来源于铜绿假单胞杆菌 (P. aeruginosa 10) 的脂多糖内毒素和 TLR4 激活剂，是 S 型 LPS。Lipopolysaccharides from P. aeruginosa 10 具有典型的 3 部分结构：O 抗原、核心寡糖和脂质 A。P. aeruginosa 10 的脂多糖具有不同于一般肠杆菌类的脂肪酸组成、异常高的磷酸化程度 (已检测到三磷酸残基) 和独特的核心寡糖的外部区域，同时其 O 特异性侧链通常富含新型氨基糖。Lipopolysaccharides, from P. aeruginosa 10 具有对病毒的易感性，并且其组分中高分子量多糖含量决定了易感性的高低。高分子量多糖的缺失会增强其对噬菌体的敏感性。

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Lipopolysaccharides, from P. aeruginosa 10 Chemical Structure

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Other Forms of Lipopolysaccharides, from P. aeruginosa 10:

Lipopolysaccharides, from E. coli O55:B5 In-stock
Lipopolysaccharides, from E. coli O111:B4 In-stock
Lipopolysaccharides, from E. coli O127:B8 In-stock
Lipopolysaccharides, from E. coli O26:B6 In-stock
Lipopolysaccharides, from Klebsiella pneumoniae In-stock
Lipopolysaccharides, from S. marcescens In-stock
Lipopolysaccharides, from E. coli O128:B12 询价
Lipopolysaccharides, from E. coli K-235 询价
Lipopolysaccharides, from Proteus vulgaris 询价
Lipopolysaccharides, from Proteus mirabilis 询价
Lipopolysaccharides, from Salmonella typhosa 询价
Lipopolysaccharides, from S. enterica serotype enteritidis 询价
Lipopolysaccharides, from S. enterica serotype minnesota 询价
Lipopolysaccharides, from S. enterica serotype typhimurium 询价
Lipopolysaccharides, from S. enterica serotype abortus equi 询价
Lipopolysaccharides, from P. gingivalis 询价

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生物活性
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参考文献

生物活性	Lipopolysaccharides from P. aeruginosa (Pseudomonas aeruginosa) 10 are lipopolysaccharide endotoxins and TLR4 activators derived from Pseudomonas aeruginosa 10, and are classified as S-type LPS. Lipopolysaccharides from P. aeruginosa 10 exhibit a typical three-part structure: O-antigen, core oligosaccharide, and lipid A. The lipopolysaccharides of P. aeruginosa 10 have a fatty acid composition distinct from common enterobacteria, an exceptionally high degree of phosphorylation (triphosphate residues have been detected), and a unique outer region of the core oligosaccharide. Additionally, their O-specific side chains are typically rich in novel aminosugars. Lipopolysaccharides from P. aeruginosa 10 demonstrate susceptibility to viruses, with the level of susceptibility determined by the content of high molecular weight polysaccharides in their composition. The absence of high molecular weight polysaccharides increases their sensitivity to bacteriophages^[1]^[2]^[3].
IC₅₀ & Target	TLR-4^[2]
体外研究 (In Vitro)	P. aeruginosa 10 可同时产生两种 O 抗原：常见多糖抗原 (CPA) 和 O 特异性抗原 (OSA)。CPA 具有常见的保守结构，由 "→3)d-Rha(α1→3)d-Rha(α1→2)d-Rha(α1→" 的重复单元组成；而 OSA 结构多变，是在血清分型中对该细菌分组的决定因素。OSA 在生物膜发育的早期阶段发挥着作用，CPA 进化能够使铜绿假单胞菌能够适应环境，在植物和土壤上形成生物膜^[1]。铜绿假单胞菌 LPS 的脂质 A 通城是六酰化和七酰化，比典型的五酰化脂质具有更有效的炎症诱导活性。并且七酰化脂质 A 常于晚期感染有关^[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Lipopolysaccharides, from P. aeruginosa 10 相关抗体:
性状	固体
颜色	White to off-white
中文名称	脂多糖,来源于铜绿假单胞菌10
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据	细胞实验： H₂O 中的溶解度 : 25 mg/mL (超声助溶) 摩尔计算器稀释计算器 Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) 质量 = 浓度 × 体积 × 分子量 * Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final) This equation is commonly abbreviated as: C₁V₁ = C₂V₂ 浓度 _(start) C1 × 体积 _(start) V1 = 浓度 _(final) C2 × 体积 _(final) V2 扫码获得动物溶解方案动物溶解方案计算器请输入动物实验的基本信息：给药剂量 mg/kg 动物的平均体重 g 每只动物的给药体积 μL 动物数量只由于实验过程有损耗，建议您多配一只动物的量计算结果工作液所需浓度 : mg/mL 该产品水溶性佳，请具体参考实测水 / PBS / Saline 中的溶解度数据。您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。免费服务热线：400-820-3792 E-mail：sales@medchemexpress.cn 技术支持电话：021-58950656 技术支持邮箱：tech@medchemexpress.cn
纯度 & 产品资料	选择批次： Data Sheet (608 KB) SDS (251 KB) COA (255 KB) 产品使用指南 (1538 KB)
参考文献	[1]. Huszczynski SM, et al. The Role of Pseudomonas aeruginosa Lipopolysaccharide in Bacterial Pathogenesis and Physiology. Pathogens. 2019 Dec 19;9(1):6. [Content Brief] [2]. Wilkinson SG. Composition and structure of lipopolysaccharides from Pseudomonas aeruginosa. Rev Infect Dis. 1983 Nov-Dec;5 Suppl 5:S941-9. [Content Brief] [3]. Cryz SJ Jr, et al. Role of lipopolysaccharide in virulence of Pseudomonas aeruginosa. Infect Immun. 1984 May;44(2):508-13. [Content Brief]

Lipopolysaccharides, from P. aeruginosa 10 相关分类

Inflammation/Immunology

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Keywords:

Lipopolysaccharides, from P. aeruginosa 10LPS, from Pseudomonas aeruginosa (10)脂多糖,来源于铜绿假单胞菌10Toll-like Receptor (TLR)Inhibitorinhibitorinhibit

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Lipopolysaccharides, from P. aeruginosa 10 (Synonyms: LPS, from Pseudomonas aeruginosa (10))

Other Forms of Lipopolysaccharides, from P. aeruginosa 10: