Lipopolysaccharides, from E. coli O127:B8 (Synonyms: LPS, from Escherichia coli (O127:B8))

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Lipopolysaccharides, from E. coli O127:B8 是一种来源于大肠杆菌 O127:B8脂多糖内毒素和 TLR-4 激活剂，可激活免疫系统的致病相关分子模式 (PAMP) 和诱导细胞分泌迁移体。Lipopolysaccharides, from E. coli O127:B8 由一个抗原 O-特异性链、一个核心寡糖和脂质 A 构成。Lipopolysaccharides, from E. coli O127:B8 可以引起大鼠体温变化且具有剂量和血清型特异性具有剂量和血清型特异性，高剂量 Lipopolysaccharides, from E. coli O127:B8 可引起了大鼠体温的双重变化，即先出现低体温然后是发热。此外，Lipopolysaccharides, from E. coli O127:B8 具有炎症诱导与生殖抑制作用，并可导致软体动物有丝分裂活性大幅度增加。

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Lipopolysaccharides, from E. coli O127:B8 Chemical Structure

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生物活性
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生物活性	Lipopolysaccharides, from E. coli O127:B8 is a lipopolysaccharide endotoxin from E. coli O127:B8 and TLR-4 activator, Activates disease-associated molecular patterns (PAMPs) of the immune system and induces cell secretion of migratory bodies. Lipopolysaccharides, from E. coli O127:B8 consists of an antigen-specific O-chain, A core oligosaccharide, and lipid A. Lipopolysaccharides, from E. coli O127:B8 can induce changes in body temperature in rats and is dose and serotype specific. High dose of Lipopolysaccharides, from E. coli O127:B8 can cause a double change of body temperature in rats, that is, hypothermia followed by fever. In addition, Lipopolysaccharides, from E. coli O127:B8 can induce inflammation and inhibit reproduction, and can significantly increase the mitotic activity of mollusks^[1]^[2]^[3]^[4]^[5]^[6]^[7].
IC₅₀ & Target	TLR-4^[2]
性状	固体
颜色	White to off-white
中文名称	脂多糖,来源于大肠杆菌O127:B8
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据	细胞实验： H₂O 中的溶解度 : 1 mg/mL (超声助溶 (<60°C)) 摩尔计算器稀释计算器 Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) 质量 = 浓度 × 体积 × 分子量 * Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final) This equation is commonly abbreviated as: C₁V₁ = C₂V₂ 浓度 _(start) C1 × 体积 _(start) V1 = 浓度 _(final) C2 × 体积 _(final) V2 扫码获得动物溶解方案动物溶解方案计算器请输入动物实验的基本信息：给药剂量 mg/kg 动物的平均体重 g 每只动物的给药体积 μL 动物数量只由于实验过程有损耗，建议您多配一只动物的量计算结果工作液所需浓度 : mg/mL 您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。免费服务热线：400-820-3792 E-mail：sales@medchemexpress.cn 技术支持电话：021-58950656 技术支持邮箱：tech@medchemexpress.cn
纯度 & 产品资料	选择批次： Data Sheet (598 KB) SDS (251 KB) COA (256 KB) 产品使用指南 (1538 KB)
参考文献	[1]. Kabanov DS, et al. Structural analysis of lipopolysaccharides from Gram-negative bacteria. Biochemistry (Mosc). 2010 Apr;75(4):383-404. [Content Brief] [2]. Cai KC, et al. Age and sex differences in immune response following LPS treatment in mice. Brain Behav Immun. 2016 Nov;58:327-337. [Content Brief] [3]. Heinrichs DE, et al. Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica. Mol Microbiol. 1998 Oct;30(2):221-32. [Content Brief] [4]. Ying Liu, et al. Podocyte-Released Migrasomes in Urine Serve as an Indicator for Early Podocyte Injury. Kidney Dis (Basel). 2020 Nov;6(6):422-433. [Content Brief] [5]. Dogan M D,et al. Effects of different serotypes of Escherichia coli lipopolysaccharides on body temperature in rats[J]. Life sciences, 2000, 67(19): 2319-2329. [6]. Castellini C,et al. Effect of LPS-induced inflammatory state on some aspects of reproductive function of rabbit does [lipopolysaccharides][J]. Italian Journal of Animal Science (Italy), 2005, 4(2). [7]. Sullivan J T,et al. Effect of crude lipopolysaccharide from Escherichia coli O127: B8 on the amebocyte-producing organ of Biomphalaria glabrata (Mollusca)[J]. Developmental & Comparative Immunology, 2011, 35(11): 1182-1185.

Lipopolysaccharides, from E. coli O127:B8 相关分类

Inflammation/Immunology

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Lipopolysaccharides, from E. coli O127:B8LPS, from Escherichia coli (O127:B8)脂多糖,来源于大肠杆菌O127:B8Toll-like Receptor (TLR)Inhibitorinhibitorinhibit

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Lipopolysaccharides, from E. coli O127:B8 (Synonyms: LPS, from Escherichia coli (O127:B8))

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Lipopolysaccharides, from E. coli O127:B8 (Synonyms: LPS, from Escherichia coli (O127:B8))

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