2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. Lipopolysaccharides, from S. enterica serotype enteritidis

Lipopolysaccharides, from S. enterica serotype enteritidis  (Synonyms: LPS, from Salmonella enterica (Serotype enteritidis))

目录号: HY-D1056C1
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Lipopolysaccharides, from S. enterica (Salmonella enterica) serotype enteritidis 是来源于肠道沙门氏菌 (S. enterica) 血清型的致肠炎脂多糖内毒素和 TLR-4 激活剂，是一种 S 型 LPS，可激活免疫系统的致病相关分子模式 (PAMP) 和诱导细胞分泌迁移体。Lipopolysaccharides, from S. enterica serotype enteritidis 具有典型的 3 部分结构：O 抗原、核心寡糖和脂质 A。Lipopolysaccharides, from S. enterica serotype enteritidis 可诱导全身炎症反应，升高血浆中的 TNF-α、IFN-γ、IL-6、IL-10 以及硝酸盐水平。
建议配制 ≥2 mg/mL 母液，并保证充分混合溶解。由于 LPS 具有吸附特性，分装保存时需使用低吸附离心管。

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Lipopolysaccharides, from S. enterica serotype enteritidis Chemical Structure

Lipopolysaccharides, from S. enterica serotype enteritidis Chemical Structure

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Lipopolysaccharides, from S. enterica serotype enteritidis 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lipopolysaccharides, from S. enterica (Salmonella enterica) serotype enteritidis are lipopolysaccharide endotoxins and TLR-4 activators derived from the enteritidis serotype of S. enterica, classified as S-type LPS, which can activate pathogen-associated molecular patterns (PAMP) of the immune system and induce cellular secretion of migrasomes. Lipopolysaccharides, from S. enterica serotype enteritidis exhibit a typical three-part structure: O-antigen, core oligosaccharide, and lipid A. Lipopolysaccharides, from S. enterica serotype enteritidis can induce systemic inflammatory responses, increasing levels of TNF-α, IFN-γ, IL-6, IL-10, and nitrate in plasma[1][2].
It is recommended to prepare a stock solution of ≥2 mg/mL and ensure that it is fully mixed and dissolved. Due to the adsorption characteristics of LPS, low adsorption centrifuge tubes should be used for aliquoting and storage.

IC50 & Target

TLR-4[2]
体外研究
(In Vitro)

Note:
1. 为了保持 LPS 的完整性，建议将 LPS 溶液存放在硅烷化容器中。因为 LPS 可以粘附在塑料和某些类型的玻璃上，尤其是在浓度低于 0.1 mg/mL 时。如果 LPS 浓度超过 1 mg/mL，这种吸附作用相对较小，建议配制 ≥2 mg/mL 母液，并保证充分混合溶解。如果使用玻璃容器，请确保使用前充分混合至少 30 分钟，以重新溶解任何吸附在管壁的 LPS。
2. LPS 是一种能在溶液中形成不同尺寸胶束的分子，分子量不固定，储备液及工作液可直接配制成质量浓度 (mg/mL, μg/mL, etc.)。
3. LPS 溶于水或 PBS 后可能会观察到均匀的浑浊溶液，如需过滤除菌，请勿直接过滤储备液，建议稀释成工作液之后用 0.22 μm 的滤膜过滤除菌。

Lipopolysaccharides, from S. enterica serotype enteritidis 介导的氧化应激程度比病原体的鞭毛蛋白 (Flagellin) 更轻，并只引发肾脏而非肝脏损伤。Lipopolysaccharides, from S. enterica serotype enteritidis 在小鼠肺中多形核中性粒细胞的滞留（髓过氧化物酶活性增加），而只有 LPS 会在肠道中募集中性粒细胞[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lipopolysaccharides, from S. enterica serotype enteritidis 相关抗体:
体内研究
(In Vivo)

Lipopolysaccharides, from S. enterica serotype enteritidis (4 mg/kg, 0.2 mL；IV；单剂量) 在小鼠模型中，诱导 TNF-α、IFN-γ、IL-6 和 IL-10 显著释放[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/c mice (8 to 10 weeks old, 25 to 30 g)[1]
Dosage: (1) 100 μg (4 mg/kg), given in 0.2 mL of vehicle (10 mM PBS [pH 7.4]). (2) 20 μg/mous or 10 μg of LPS plus 10 μg of flagellin/mouse.
Administration: Intravenous injection, via the tail vein; single dose.
Result: Induced a significant increase in MPO after 8 h in n the liver and kidney.
Decreased the levels of reduced glutathione in tissue in a comparable way in the lung, gut, and kidney.
Compared treatment separately, significantly enhanced the release of both cytokines when injected LPS and flagellin together.
同用名

LPS, from Salmonella enterica (Serotype enteritidis)

性状

固体

颜色

White to off-white

中文名称

脂多糖,来源于肠沙门氏菌肠炎血清型
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献

Lipopolysaccharides, from S. enterica serotype enteritidis 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lipopolysaccharides, from S. enterica serotype enteritidisLPS, from Salmonella enterica (Serotype enteritidis)脂多糖,来源于肠沙门氏菌肠炎血清型Toll-like Receptor (TLR)Inhibitorinhibitorinhibit

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