2. Cell Cycle/DNA Damage Anti-infection
  3. Topoisomerase Fungal TMV
  4. Luotonin A

Luotonin A 是一种抗病毒 (antiviral) 和抗植物致病真菌 (fungus) 剂。Luotonin A 对烟草花叶病毒 (TMV) 具有良好的抗病毒活性。Luotonin A 对拓扑异构酶 I (topoisomerase I) 和拓扑异构酶 II (topoisomerase II) 也有一定的抑制活性。Luotonin A 具有抗肿瘤活性。

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Luotonin A Chemical Structure

Luotonin A Chemical Structure

CAS No. : 205989-12-4

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Luotonin A 相关抗体

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Topoisomerase Topo I Topo II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Luotonin A is an antiviral and antiphytopathogenic fungus agent. Luotonin A has good antiviral activity against tobacco mosaic virus (TMV). Luotonin A also has certain inhibitory activity on topoisomerase I and topoisomerase II. Luotonin A shows antitumor activity[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
61.25 μM
Compound: 10
Cytotoxicity against Homo sapiens (human) A549 cells assessed as growth inhibition after 48 hr by MTT assay
Cytotoxicity against Homo sapiens (human) A549 cells assessed as growth inhibition after 48 hr by MTT assay
10.1007/s00044-012-0018-x
CCRF-CEM GI50
≥ 40 μM
Compound: 1a, luotonin A
Growth inhibition of human CEM cells by Alamar blue assay
Growth inhibition of human CEM cells by Alamar blue assay
[PMID: 17418582]
CEM/C2 GI50
> 40 μM
Compound: 1a, luotonin A
Growth inhibition of topoisomerase 1 mutated CEM/C2 cells by Alamar blue assay
Growth inhibition of topoisomerase 1 mutated CEM/C2 cells by Alamar blue assay
[PMID: 17418582]
HEK293 IC50
58 μM
Compound: 1
Cytotoxicity against HEK cells after 72 hrs by MTT assay
Cytotoxicity against HEK cells after 72 hrs by MTT assay
[PMID: 25757092]
HeLa GI50
3 μM
Compound: 1a, luotonin A
Growth inhibition of HeLa cells after 4 days
Growth inhibition of HeLa cells after 4 days
[PMID: 17418582]
HeLa IC50
5.94 μM
Compound: 1
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
[PMID: 25757092]
HeLa IC50
6.4 μM
Compound: 1
Inhibition of HDAC1/2 in human HeLa cells using color de lys as substrate after 30 mins by colorimetric analysis
Inhibition of HDAC1/2 in human HeLa cells using color de lys as substrate after 30 mins by colorimetric analysis
[PMID: 25757092]
K562 IC50
28.8 μM
Compound: 1
Cytotoxicity against human K562 cells after 72 hrs by MTT assay
Cytotoxicity against human K562 cells after 72 hrs by MTT assay
[PMID: 25757092]
MCF7 GI50
3 μM
Compound: 1a, luotonin A
Growth inhibition of MCF7 cells after 4 days
Growth inhibition of MCF7 cells after 4 days
[PMID: 17418582]
MCF7 GI50
5 μM
Compound: 1a, luotonin A
Growth inhibition of adriamycin-resistant MCF7 cells after 4 days
Growth inhibition of adriamycin-resistant MCF7 cells after 4 days
[PMID: 17418582]
MCF7 IC50
9.28 μM
Compound: 1
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 25757092]
NCI-H460 IC50
67 μM
Compound: 1a
In vitro inhibitory concentration against human lung large cell carcinoma cell line, H460 (after 1 hour exposure)
In vitro inhibitory concentration against human lung large cell carcinoma cell line, H460 (after 1 hour exposure)
[PMID: 15501036]
NCI-H460 IC50
7.7 μM
Compound: 1a
In vitro inhibitory concentration against human lung large cell carcinoma cell line, H460 (after 72 hours exposure)
In vitro inhibitory concentration against human lung large cell carcinoma cell line, H460 (after 72 hours exposure)
[PMID: 15501036]
SK-N-SH IC50
61.08 μM
Compound: 10
Cytotoxicity against Homo sapiens (human) SK-N-SH cells assessed as growth inhibition after 48 hr by MTT assay
Cytotoxicity against Homo sapiens (human) SK-N-SH cells assessed as growth inhibition after 48 hr by MTT assay
10.1007/s00044-012-0018-x
分子量

285.30

Formula

C18H11N3O
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
纯度 & 产品资料
参考文献

Luotonin A 相关分类

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C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Luotonin A205989-12-4TopoisomeraseFungalTMVTobacco mosaic virustobacco mosaic virusPeganum nigellastrum BungeP-388Inhibitorinhibitorinhibit

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目录号：
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