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  3. LY-195448 hydrochloride

LY-195448 hydrochloride是一种苯乙醇胺,在各种鼠肿瘤模型中表现出抗肿瘤活性。LY-195448 hydrochloride 通过阻断中期细胞起作用。LY-195448 hydrochloride 已证明没有癌症抑制中常见的“标准”副作用,例如骨髓抑制和胃肠道毒性。LY-195448 hydrochloride 在 I 期试验中进行了评估,结果显示它仅表现出轻微且可逆的副作用,例如低血压、心动过速和震颤。

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LY-195448 hydrochloride Chemical Structure

LY-195448 hydrochloride Chemical Structure

CAS No. : 111112-18-6

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  • 生物活性

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生物活性

LY-195448 hydrochloride is a phenethanolamine that exhibits anti-tumour activity across various murine tumour models. LY-195448 hydrochloride acts by blocking cells at metaphase. LY-195448 hydrochloride has demonstrated a lack of "standard" side effects commonly associated with cancer treatments, such as myelosuppression and gastrointestinal toxicity. LY-195448 hydrochloride was evaluated in a phase I trial, where it showed only mild and reversible side effects like hypotension, tachycardia, and tremor.

分子量

362.89

Formula

C20H27ClN2O2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

LY-195448 hydrochloride 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
LY-195448 hydrochloride
目录号:
HY-119200
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