2. Metabolic Enzyme/Protease
  3. MMP
  4. LY52

LY52 是一种 MMP-2 和 MMP-9 抑制剂。 LY52 可显著阻断明胶酶的蛋白水解活性，减少 SKOV3 细胞中 MMP-2 和 MMP-9 的表达，从而抑制细胞侵袭。LY52 还可以在小鼠体内抑制 Lewis 肺癌细胞肺部转移。LY52 可用于抗癌领域研究。

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LY52 Chemical Structure

LY52 Chemical Structure

CAS No. : 769970-91-4

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LY52 相关抗体

Top Publications Citing Use of Products

查看 MMP 亚型特异性产品:

查看所有亚型
MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LY52 is an MMP-2 and MMP-9 inhibitor. LY52 can significantly block the proteolytic activity of gelatinases, reducing the expression of MMP-2 and MMP-9 in SKOV3 cells, thereby inhibiting cell invasion. LY52 can also suppress the pulmonary metastasis of Lewis lung carcinoma cells in mice. LY52 may be used in cancer research[1].

IC50 & Target

MMP-9

 

MMP-2

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
> 1000 μM
Compound: LY52
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
[PMID: 24755524]
A549 IC50
78.25 μM
Compound: LY52
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
[PMID: 30093347]
C8166 CC50
> 454.37 μM
Compound: LY52
Cytotoxicity against human C8166 cells after 72 hrs by MTT assay
Cytotoxicity against human C8166 cells after 72 hrs by MTT assay
[PMID: 27039251]
C8166 EC50
32.99 μM
Compound: LY52
Antiviral activity against HIV1 3B infected in human C8166 cells assessed as cytopathic effect by counting the number of syncytia by microscopy
Antiviral activity against HIV1 3B infected in human C8166 cells assessed as cytopathic effect by counting the number of syncytia by microscopy
[PMID: 27039251]
HeLa IC50
184.62 μM
Compound: LY52
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
[PMID: 30093347]
HL-60 IC50
> 1000 μM
Compound: LY52
Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay
Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay
[PMID: 24755524]
HUVEC CC50
39.84 μM
Compound: LY52
Cytotoxicity against HUVEC after 48 hrs by MTT assay
Cytotoxicity against HUVEC after 48 hrs by MTT assay
[PMID: 30093347]
K562 IC50
> 200 μM
Compound: LY52
Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
[PMID: 30093347]
MCF7 IC50
> 200 μM
Compound: LY52
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 30093347]
MDA-MB-231 IC50
> 200 μM
Compound: LY52
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
[PMID: 30093347]
SK-OV-3 IC50
0.21 mM
Compound: LY52
Antiproliferative activity against human SKOV3 cells after 48 hrs by MTT assay
Antiproliferative activity against human SKOV3 cells after 48 hrs by MTT assay
[PMID: 20097082]
SK-OV-3 IC50
43.75 μM
Compound: LY52
Inhibition of MMP2 in human SKOV3 cell suspension using succinylated gelatin as substrate preincubated for 10 mins before substrate addition measured after 30 mins by spectrophotometry
Inhibition of MMP2 in human SKOV3 cell suspension using succinylated gelatin as substrate preincubated for 10 mins before substrate addition measured after 30 mins by spectrophotometry
[PMID: 24755524]
SK-OV-3 IC50
697.14 μM
Compound: LY52
Antiproliferative activity against human SKOV3 cells after 48 hrs by MTT assay
Antiproliferative activity against human SKOV3 cells after 48 hrs by MTT assay
[PMID: 24755524]
分子量

440.45

Formula

C22H24N4O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LY52 相关分类

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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY52769970-91-4LY 52LY-52MMPMatrix metalloproteinasesInhibitorinhibitorinhibit

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