2. Academic Validation
  3. In vitro activity of a new isothiazoloquinolone, ACH-702, against Mycobacterium tuberculosis and other mycobacteria

In vitro activity of a new isothiazoloquinolone, ACH-702, against Mycobacterium tuberculosis and other mycobacteria

  • Antimicrob Agents Chemother. 2010 May;54(5):2188-90. doi: 10.1128/AAC.01603-09.
Carmen A Molina-Torres 1,  Jorge Ocampo-Candiani,  Adrian Rendón,  Michael J Pucci,  Lucio Vera-Cabrera
Affiliations

Affiliation

  • 1 Servicio de Dermatología, Hospital Universitario José E. González, Monterrey, Nuevo León, México.
PMID: 20231398 DOI: 10.1128/AAC.01603-09
Abstract

In this work, we describe the activity of ACH-702 against clinical isolates of Mycobacterium tuberculosis and six different nontuberculous mycobacteria. The MIC(50) and MIC(90) of both susceptible and drug-resistant M. tuberculosis strains tested were 0.0625 and 0.125 microg/ml, respectively. The MIC(50) and MIC(90) values for Mycobacterium fortuitum isolates were 0.0625 microg/ml in both cases; Mycobacterium avium complex isolates showed MIC(50) and MIC(90) values of 0.25 and 4 microg/ml, respectively.

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