2. Academic Validation
  3. Cytotoxic constituents from the rhizomes of Curcuma zedoaria

Cytotoxic constituents from the rhizomes of Curcuma zedoaria

  • ScientificWorldJournal. 2014:2014:321943. doi: 10.1155/2014/321943.
Omer Abdalla Ahmed Hamdi 1,  Syarifah Nur Syed Abdul Rahman 2,  Khalijah Awang 1,  Norhanom Abdul Wahab 3,  Chung Yeng Looi 4,  Noel Francis Thomas 5,  Sri Nurestri Abd Malek 6
Affiliations

Affiliations

  • 1 Center for Natural Products and Drugs Discovery (CENAR), University of Malaya, 50603 Kuala Lumpur, Malaysia ; Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
  • 2 Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
  • 3 Center for Natural Products and Drugs Discovery (CENAR), University of Malaya, 50603 Kuala Lumpur, Malaysia ; Biology Division, Center for Foundation Studies in Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
  • 4 Center for Natural Products and Drugs Discovery (CENAR), University of Malaya, 50603 Kuala Lumpur, Malaysia ; Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
  • 5 Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
  • 6 Center for Natural Products and Drugs Discovery (CENAR), University of Malaya, 50603 Kuala Lumpur, Malaysia ; Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
PMID: 25126594 DOI: 10.1155/2014/321943
Abstract

Curcuma zedoaria also known as Temu putih is traditionally used in food preparations and treatment of various ailments including Cancer. The cytotoxic activity of hexane, dichloromethane, ethyl acetate, methanol, and the methanol-soxhlet extracts of Curcuma zedoaria rhizomes was tested on two human Cancer cell lines (CA Ski and MCF-7) and a noncancer cell line (HUVEC) using MTT assay. Investigation on the chemical components in the hexane and dichloromethane fractions gave 19 compounds, namely, labda-8(17),12 diene-15,16 dial (1), dehydrocurdione (2), curcumenone (3), comosone II (4), curcumenol (5), procurcumenol (6), germacrone (7), zerumbone epoxide (8), zederone (9), 9-isopropylidene-2,6-dimethyl-11-oxatricyclo[6.2.1.0(1,5)]undec-6-en-8-ol (10), furanodiene (11), germacrone-4,5-epoxide (12), calcaratarin A (13), isoprocurcumenol (14), germacrone-1,10-epoxide (15), zerumin A (16), curcumanolide A (17), curcuzedoalide (18), and gweicurculactone (19). Compounds (1-19) were evaluated for their antiproliferative effect using MTT assay against four Cancer cell lines (CA Ski, MCF-7, PC-3, and HT-29). Curcumenone (3) and curcumenol (5) displayed strong antiproliferative activity (IC50 = 8.3 ± 1.0 and 9.3 ± 0.3 μg/mL, resp.) and were found to induce apoptotic cell death on MCF-7 cells using phase contrast and Hoechst 33342/PI double-staining assay. Thus, the present study provides basis for the ethnomedical application of Curcuma zedoaria in the treatment of breast Cancer.

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