Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia

Affiliations

• 1 Department of Biochemistry and Biophysics, and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC;
• 2 Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, NY;
• 3 Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC;
• 4 Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina at Chapel Hill, Chapel Hill, NC;
• 5 Department of Genetics, and Departments of Neurology and Neuroscience, Albert Einstein College of Medicine, Bronx, NY;
• 6 Epigenetics Program, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA;
• 7 Ansary Stem Cell Institute and Department of Genetic Medicine, Weill Cornell Medical College, New York, NY; and.
• 8 Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.
• 9 Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC; Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina at Chapel Hill, Chapel Hill, NC;