2. Academic Validation
  3. Preparation and properties of calcium citrate nanosheets for bone graft substitute

Preparation and properties of calcium citrate nanosheets for bone graft substitute

  • Bioengineered. 2016 Sep 2;7(5):376-381. doi: 10.1080/21655979.2016.1226656.
Junfeng Li 1,  Yuqing Liu 1,  Yang Gao 1,  Liangzhao Zhong 1,  Qin Zou 2,  Xuefei Lai 3
Affiliations

Affiliations

  • 1 a College of Materials, Chemistry & Chemical Engineering, Chengdu University of Technology , Chengdu, Sichuan , P.R. China.
  • 2 b Research Center for Nano-Biomaterials , Analytical & Testing Center, Sichuan University , Chengdu, Sichuan , P.R. China.
  • 3 c College of Chemical Engineering, Sichuan University, Chengdu , Sichuan , P.R. China.
PMID: 27710434 DOI: 10.1080/21655979.2016.1226656
Abstract

A convenient and effective soft chemical method is presented for the synthesis of nano-scaled calcium citrate sheets. The preparation involved the precipitation of nano-calcium citrate by adding ethanol to reach the super saturation state of a solution containing calcium and citrate salts. The obtained nano-calcium citrate formed nanosheets, with the following dimensions: width of about 50∼500 nm and thickness of about 8∼30 nm. The results of the XRD analysis confirmed that the obtained sample is calcium citrate tetrahydrate, and the crystal degree decreased with an increase quantity of ethanol added. Animal experiments showed that the calcium citrate can promote the formation of new bone.

Keywords

animal experiment; bone graft substitute; calcium citrate; nanosheet; soft chemistry synthesis.

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