2. Academic Validation
  3. Bioactive Triterpenoids from the Twigs of Chaenomeles sinensis

Bioactive Triterpenoids from the Twigs of Chaenomeles sinensis

  • J Nat Prod. 2017 Apr 28;80(4):1134-1140. doi: 10.1021/acs.jnatprod.7b00111.
Chung Sub Kim 1,  Lalita Subedi 2 3,  Joonseok Oh 4 5,  Sun Yeou Kim 2 3,  Sang Un Choi 6,  Kang Ro Lee 1
Affiliations

Affiliations

  • 1 Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University , Suwon 16419, Republic of Korea.
  • 2 Gachon Institute of Pharmaceutical Science, Gachon University , Incheon 21936, Republic of Korea.
  • 3 College of Pharmacy, Gachon University , #191, Hambakmoero, Yeonsu-gu, Incheon 21936, Republic of Korea.
  • 4 Department of Chemistry, Yale University , New Haven, Connecticut 06520, United States.
  • 5 Chemical Biology Institute, Yale University , West Haven, Connecticut 06516, United States.
  • 6 Korea Research Institute of Chemical Technology , Daejeon 34114, Republic of Korea.
PMID: 28358502 DOI: 10.1021/acs.jnatprod.7b00111
Abstract

Chaenomeles sinensis has been consumed traditionally for the treatment of throat diseases, diarrhea, inflammatory diseases, and dry beriberi. Repeated chromatography of the CHCl3-soluble fraction from the 80% MeOH extract of C. sinensis twigs led to the isolation of three new triterpenoids, sinenic acid A (1), 3β-O-cis-feruloyl-2α,19α-dihydroxyurs-12-en-28-oic acid (2), and 3β-O-cis-caffeoylbetulin (3), together with 20 analogues. The chemical structures of 1-3 were determined using diverse NMR techniques and HRMS data analysis, chemical methods, and computational approaches supported by advanced statistics (CP3). All the purified compounds were evaluated not only for their cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15) but for their potential neuroprotective effects through induction of nerve growth factor in C6 glioma cells. Their anti-inflammatory effects were also assessed by measuring nitric oxide levels in lipopolysaccharide-insulted murine microglia BV2 cells.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z