2. Academic Validation
  3. Analyzing the role of cannabinoids as modulators of Wnt/β-catenin signaling pathway for their use in the management of neuropathic pain

Analyzing the role of cannabinoids as modulators of Wnt/β-catenin signaling pathway for their use in the management of neuropathic pain

  • Bioorg Med Chem Lett. 2019 May 1;29(9):1043-1046. doi: 10.1016/j.bmcl.2019.03.013.
Yedukondalu Nalli 1,  Mohd Saleem Dar 2,  Nasima Bano 2,  Javeed Ur Rasool 3,  Aminur R Sarkar 1,  Junaid Banday 1,  Aadil Qadir Bhat 2,  Basit Rafia 2,  Ram A Vishwakarma 4,  Mohd Jamal Dar 5,  Asif Ali 6
Affiliations

Affiliations

  • 1 Natural Product Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India.
  • 2 Academy of Scientific and Innovative Research, New Delhi, India; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India.
  • 3 Academy of Scientific and Innovative Research, New Delhi, India.
  • 4 Natural Product Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India.
  • 5 Academy of Scientific and Innovative Research, New Delhi, India; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India. Electronic address: jamal@iiim.ac.in.
  • 6 Natural Product Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific and Innovative Research, New Delhi, India. Electronic address: asifali@iiim.ac.in.
PMID: 30871771 DOI: 10.1016/j.bmcl.2019.03.013
Abstract

Neuropathic pain is a debilitating form of treatment-resistant chronic pain caused by damage to the nervous system. Cannabinoids have been known for suppressing neuropathic pain by modulating the endo cannabinoid system. Since the canonical Wnt/β-catenin signaling has recently been implicated in pain sensation, we investigated the impact of major cannabinoids (1-6) from the leaves of Cannabis sativa and an epoxy derivative of compound 2, here upon referred to as 2a, on modulating Wnt/β-catenin signaling pathway. The results presented in this study show that compound 1, 2 and 2a exhibited potent inhibitory activity against Wnt/β-catenin pathway in a dose-dependent manner. Compound 2a was seen to inhibit this pathway at slightly lower concentrations than its parent molecule 2, under similar conditions. Taken together, compound 1, 2 and 2a, by virtue of their inhibition of Wnt/β-catenin signaling pathway, could be developed as effective neuroprotective agents for the management of neuropathic pain.

Keywords

Anti-proliferative activity; Cannabinoids; Cannabis sativa; Neuropathic pain; Wnt/β-catenin signaling.

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