2. Academic Validation
  3. Extracellular microvesicles-derived from microglia treated with unaggregated α-synuclein attenuate mitochondrial fission and toxicity-induced by Parkinsonian toxin MPP

Extracellular microvesicles-derived from microglia treated with unaggregated α-synuclein attenuate mitochondrial fission and toxicity-induced by Parkinsonian toxin MPP

  • Biochem Biophys Res Commun. 2019 Oct 1;517(4):642-647. doi: 10.1016/j.bbrc.2019.07.084.
Na Li 1,  Yufeng Wu 2,  Liangyi Zhu 1,  Yang Huang 1,  Zongran Liu 1,  Min Shi 3,  David Soltys 3,  Jing Zhang 4,  Qing Chang 5
Affiliations

Affiliations

  • 1 Department of Pathology, School of Basic Medical Sciences, Peking University Third Hospital, Peking University Health Science Center, Beijing, 100191, China.
  • 2 Department of Laboratory Medicine, Peking University Third Hospital, Peking University Health Science Center, Beijing, China.
  • 3 Department of Pathology, University of Washington, Seattle, WA, 98106, USA.
  • 4 Department of Pathology, University of Washington, Seattle, WA, 98106, USA. Electronic address: zhangj@uw.edu.
  • 5 Department of Pathology, School of Basic Medical Sciences, Peking University Third Hospital, Peking University Health Science Center, Beijing, 100191, China. Electronic address: qingchang@bjmu.edu.cn.
PMID: 31402119 DOI: 10.1016/j.bbrc.2019.07.084
Abstract

Biological functions of extracellular vesicles (EVs) are being discovered to be critical in neurodegenerative disorders, including Parkinson's disease (PD). A previous study using cellular models of PD has suggested that EVs derived from microglia exposed to aggregated α-synuclein (α-Syn) leads to enhanced neurotoxicity. However, the function of EVs derived from microglia not treated with aggregated a-Syn or treated with monomeric α-Syn are unclear. Here, employing a widely used cellular model of PD, i.e. SH-SY5Y cells treated with MPP+, a well-established parkinsonian toxicant, we revealed that microglial EVs, when not stimulated by aggregated α-Syn, appeared to be protective, and the mechanisms, though remain to be defined further, appeared to involve mitochondrial dynamics, especially mitochondrial fission.

Keywords

MPP(+); Microglia-derived EVs; Mitochondrial fission/fusion; PD cell model; α-synuclein.

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