2. Academic Validation
  3. Safety review of phenoxyethanol when used as a preservative in cosmetics

Safety review of phenoxyethanol when used as a preservative in cosmetics

  • J Eur Acad Dermatol Venereol. 2019 Nov;33 Suppl 7:15-24. doi: 10.1111/jdv.15944.
B Dréno 1,  T Zuberbier 2,  C Gelmetti 3,  G Gontijo 4,  M Marinovich 5
Affiliations

Affiliations

  • 1 Dermatology Department, CHU Nantes, CIC 1413 CRCINA, University of Nantes, Nantes, France.
  • 2 Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • 3 UOC Dermatologia Pediatrica, IRCCS Fondazione Ca' Granda "Ospedale Maggiore Policlinico", Dipartimento di Fisiopatologia Medico-Chirurgica, Università degli Studi di Milano, Milan, Italy.
  • 4 Department of Dermatology, UFMG Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  • 5 Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.
PMID: 31588615 DOI: 10.1111/jdv.15944
Abstract

Phenoxyethanol, or 2-phenoxyethanol, has a large spectrum of antimicrobial activity and has been widely used as a preservative in cosmetic products for decades. It is effective against various Gram-negative and Gram-positive bacteria, as well as against yeasts, and has only a weak inhibitory effect on resident skin flora. According to the European Scientific Committee on Consumer Safety, phenoxyethanol is safe for all consumers - including children of all ages - when used as a preservative in cosmetic products at a maximum concentration of 1%. Adverse systemic effects have been observed in toxicological studies on Animals but only when the levels of exposure were many magnitudes higher (around 200-fold higher) than those to which consumers are exposed when using phenoxyethanol-containing cosmetic products. Despite its widespread use in cosmetic products, phenoxyethanol is a rare sensitizer. It can be considered as one of the most well-tolerated Preservatives used in cosmetic products.

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