2. Academic Validation
  3. Benfuracarb inhibits body growth and causes oxidative stress in zebrafish (Danio rerio)

Benfuracarb inhibits body growth and causes oxidative stress in zebrafish (Danio rerio)

  • Chemosphere. 2022 Mar;291(Pt 2):132955. doi: 10.1016/j.chemosphere.2021.132955.
Shanshan Guo 1,  Yaqing Wu 2,  Peng Xiao 3,  Wenhua Li 4
Affiliations

Affiliations

  • 1 Engineering Research Center of Molecular Medicine of Ministry of Education, Key Laboratory of Fujian Molecular Medicine, Key Laboratory of Xiamen Marine and Gene Drugs, Key Laboratory of Precision Medicine and Molecular Diagnosis of Fujian Universities, School of Biomedical Sciences, Huaqiao University, Xiamen, 361021, PR China.
  • 2 Instrumental Analysis Center of Huaqiao University, Xiamen, 361021, PR China.
  • 3 College of Life and Environmental Science, Wenzhou University, Wenzhou, 325035, PR China.
  • 4 Engineering Research Center of Molecular Medicine of Ministry of Education, Key Laboratory of Fujian Molecular Medicine, Key Laboratory of Xiamen Marine and Gene Drugs, Key Laboratory of Precision Medicine and Molecular Diagnosis of Fujian Universities, School of Biomedical Sciences, Huaqiao University, Xiamen, 361021, PR China. Electronic address: wenhuali@hqu.edu.cn.
PMID: 34801571 DOI: 10.1016/j.chemosphere.2021.132955
Abstract

Benfuracarb (BEN), a broad-spectrum carbamate insecticide used for crop protection, is considered toxic to humans and aquatic organisms. However, the potential risk level of BEN to aquatic organisms is still unclear. In this study, we exposed zebrafish embryos to BEN (0.08, 0.49, and 0.90 mg/L) from 3 to 96 hours post-fertilization (hpf). The results showed that BEN caused shorter body length in zebrafish larvae. The activity of superoxide dismutase (SOD) was significantly increased after BEN exposure. Furthermore, the transcription levels of marker genes associated with early embryonic development (myoD, nkx2.4b, myh6, and gh) were disrupted after BEN treatment. Taken together, the data indicate that BEN possesses developmental toxicity to zebrafish. The results provide a valuable reference for assessing BEN's potentially harmful effects on aquatic ecosystems.

Keywords

Benfuracarb; Body length; Embryo; Oxidative stress; Zebrafish.

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