2. Academic Validation
  3. Astrocytic Piezo1-mediated mechanotransduction determines adult neurogenesis and cognitive functions

Astrocytic Piezo1-mediated mechanotransduction determines adult neurogenesis and cognitive functions

  • Neuron. 2022 Sep 21;110(18):2984-2999.e8. doi: 10.1016/j.neuron.2022.07.010.
Shaopeng Chi 1,  Yaxiong Cui 1,  Haiping Wang 1,  Jinghui Jiang 1,  Tingxin Zhang 1,  Suhua Sun 2,  Zhuan Zhou 2,  Yi Zhong 3,  Bailong Xiao 4
Affiliations

Affiliations

  • 1 State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, IDG/McGovern Institute for Brain Research, Beijing Frontier Research Center for Biological Structure, Beijing Advanced Innovation Center for Structural Biology, School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China.
  • 2 State Key Laboratory of Membrane Biology, Peking-Tsinghua Center for Life Sciences, PKU-IDG/McGovern Institute for Brain Research, College of Future Technology, Peking University, Beijing 100871, China.
  • 3 Tsinghua-Peking Center for Life Sciences, IDG/McGovern Institute for Brain Research, School of Life Science, Tsinghua University, Beijing 100084, China.
  • 4 State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, IDG/McGovern Institute for Brain Research, Beijing Frontier Research Center for Biological Structure, Beijing Advanced Innovation Center for Structural Biology, School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China. Electronic address: xbailong@mail.tsinghua.edu.cn.
PMID: 35963237 DOI: 10.1016/j.neuron.2022.07.010
Abstract

Adult brain activities are generally believed to be dominated by chemical and electrical transduction mechanisms. However, the importance of mechanotransduction mediated by mechano-gated ion channels in brain functions is less appreciated. Here, we show that the mechano-gated Piezo1 channel is expressed in the exploratory processes of astrocytes and utilizes its mechanosensitivity to mediate mechanically evoked CA2+ responses and ATP release, establishing Piezo1-mediated mechano-chemo transduction in astrocytes. Piezo1 deletion in astrocytes causes a striking reduction of hippocampal volume and brain weight and severely impaired (but ATP-rescuable) adult neurogenesis in vivo, and it abolishes ATP-dependent potentiation of neural stem cell (NSC) proliferation in vitro. Piezo1-deficient mice show impaired hippocampal long-term potentiation (LTP) and learning and memory behaviors. By contrast, overexpression of Piezo1 in astrocytes sufficiently enhances mechanotransduction, LTP, and learning and memory performance. Thus, astrocytes utilize Piezo1-mediated mechanotransduction mechanisms to robustly regulate adult neurogenesis and cognitive functions, conceptually highlighting the importance of mechanotransduction in brain structure and function.

Keywords

ATP; LTP; Piezo1; adult neurogenesis; astrocyte; calcium; learning; mechano-gated channel; mechanotransduction; memory.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z