2. Academic Validation
  3. Two polyphenols isolated from Corallodiscus flabellata B. L. Burtt ameliorate amyloid β-protein induced Alzheimer's disease neuronal injury by improving mitochondrial homeostasis

Two polyphenols isolated from Corallodiscus flabellata B. L. Burtt ameliorate amyloid β-protein induced Alzheimer's disease neuronal injury by improving mitochondrial homeostasis

  • Behav Brain Res. 2022 Dec 16;440:114264. doi: 10.1016/j.bbr.2022.114264.
Bing Cao 1,  Mengnan Zeng 2,  Fengxiao Hao 3,  Changqing Zhao 4,  Beibei Zhang 5,  Yuanyuan Wu 6,  Yuhan Zhang 7,  Meng Li 8,  Weisheng Feng 9,  Xiaoke Zheng 10
Affiliations

Affiliations

  • 1 College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, China. Electronic address: cb960821@163.com.
  • 2 College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, China. Electronic address: 17320138484@163.com.
  • 3 College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, China. Electronic address: 2978640783@qq.com.
  • 4 College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China. Electronic address: 2283217595@qq.com.
  • 5 College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, China. Electronic address: WYY96191711@163.com.
  • 6 College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, China. Electronic address: zyh1306228674@163.com.
  • 7 College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, China. Electronic address: zhangs9426@163.com.
  • 8 College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, China. Electronic address: limeng31716@163.com.
  • 9 College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, China. Electronic address: fwsh@hactcm.edu.cn.
  • 10 College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, China. Electronic address: zhengxk.2006@163.com.
PMID: 36535434 DOI: 10.1016/j.bbr.2022.114264
Abstract

Corallodiscus flabellata B. L. Burtt (CF) is a Chinese folk herb with reported potential for the treatment of Alzheimer's disease (AD). 3,4-Dihydroxyphenylethanol-8-O-[4-O-trans-caffeoyl-β-D-apiofuranosyl-(1→3)-β-D-glucopyranosyl (1→6)][1]-β-D-glucopyranoside (SDC-1-8) and hydroxytyrosol (HT) are two polyphenolic compounds isolated from CF. The aim of this study was to investigate the protective effects of SDC-1-8 and HT on an Aβ25-35-induced AD model and to study the underlying mechanism. The AD mouse model was established using a brain injection of amyloid β-protein 25-35 (Aβ25-35, 200 μM), followed by continuous administration of SDC-1-8 and HT for 4 weeks, and found that they improved cognitive dysfunction; ameliorated neuronal damage and apoptosis; decreased oxidative stress, and mitochondrial fission protein levels; and increased mitochondrial fusion protein levels in AD mice. Moreover, SDC-1-8 and HT inhibited mitochondrial membrane depolarization, reduced intracellular stored CA2+ levels, enhanced mitochondrial respiration, increased mitochondrial fusion, and decreased mitochondrial division in Aβ25-35-induced PC12 cells even in the presence of mdivi-1. Furthermore, molecular docking simulations showed that SDC-1-8 and HT interacted with dynamin-related protein 1 with higher affinity than mitofusin 1. Thus, it is summarized that SDC-1-8 and HT may have neuroprotective effects by balancing the abnormalities of mitochondrial fission and fusion, and SDC-1-8 and HT are the components providing the therapeutic basis of CF.

Keywords

3,4-Dihydroxyphenylethanol-8-O-[4-O-trans-caffeoyl-β-D-apiofuranosyl-(1→3)-β-D-glucopyranosyl (1→6)]-β-D-glucopyranoside; Alzheimer's disease; Aβ(25–35); Hydroxytyrosol; Mitochondrial fission; Mitochondrial fusion.

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