2. Academic Validation
  3. A cytotoxicity and mechanistic investigation of mono- and di-chloro naphthalenes

A cytotoxicity and mechanistic investigation of mono- and di-chloro naphthalenes

  • Chemosphere. 2024 Feb:350:141004. doi: 10.1016/j.chemosphere.2023.141004.
Chenglin Cai 1,  Jiajun Qian 2,  Shouyan Xiang 3,  Chenhao Wang 3,  Yufeng Ji 4,  Jiahua Cui 5,  Jinping Jia 6
Affiliations

Affiliations

  • 1 China-UK Low Carbon College, Shanghai Jiao Tong University, Shanghai, China.
  • 2 School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China.
  • 3 School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, China.
  • 4 Faculty of Engineering and Information Technology, The University of Melbourne, Melbourne, Australia.
  • 5 School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China. Electronic address: cpucjh@sjtu.edu.cn.
  • 6 China-UK Low Carbon College, Shanghai Jiao Tong University, Shanghai, China; School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China. Electronic address: jpjia@sjtu.edu.cn.
PMID: 38141682 DOI: 10.1016/j.chemosphere.2023.141004
Abstract

Polychlorinated naphthalenes (PCNs) were characterized as persistent organic pollutants (POPs) that were widely distributed in the environment. Although the striking in vivo toxicity of these pollutants towards both Animals and humans was well documented, their cytotoxicity and mechanism of action have not been extensively investigated. In this study, the in vitro antiproliferative activity of mono- and di-chloronaphthalenes as representative PCNs were evaluated and the results indicated strong growth inhibitory effects against mammalian cells, especially the human breast MCF-10A cell and human hepatic HL-7702 cells. 2-Chloronaphthalene with the most potent antiproliferative effects within the tested PCNs, which showed IC50 values ranging from 0.3 mM to 1.5 mM against selected human cell lines, was investigated for its working mechanisms. It promoted cellular Apoptosis of MCF-10A cells upon the concentration of 200 μM. It also induced the Autophagy of MCF-10A cells in a dose-dependent manner, resulting in cell death via the interaction of Autophagy and Apoptosis. Thus, these findings supported the theoretical foundation for interventional treatment of PCNs toxicity and also provided implications for the use of chemopreventive agents against the toxic chlorinated naphthalenes in the environments.

Keywords

Apoptosis; Autophagy; Chloronaphthalenes; Cytotoxicity; Volatile organic compounds.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z