2. Academic Validation
  3. Multicargo-loaded inverse opal gelatin hydrogel microparticles for promoting bacteria-infected wound healing

Multicargo-loaded inverse opal gelatin hydrogel microparticles for promoting bacteria-infected wound healing

  • Int J Biol Macromol. 2024 Jan 17:129557. doi: 10.1016/j.ijbiomac.2024.129557.
Wenhan Li 1,  Haiwen Su 2,  Yanyu Ma 3,  Haoyu Ren 4,  Zhenhua Feng 3,  Yu Wang 3,  Yong Qiu 3,  Hengjin Wang 2,  Huan Wang 5,  Quanchi Chen 6,  Zezhang Zhu 7
Affiliations

Affiliations

  • 1 Division of Spine Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing 210008, China.
  • 2 Department of Nephrology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing 210008, China.
  • 3 Division of Spine Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China.
  • 4 The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, China.
  • 5 The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, China. Electronic address: wangh679@mail.sysu.edu.cn.
  • 6 Division of Spine Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China. Electronic address: quanchichen@njglyy.com.
  • 7 Division of Spine Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing 210008, China; Division of Spine Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China. Electronic address: zhuzezhang@126.com.
PMID: 38242411 DOI: 10.1016/j.ijbiomac.2024.129557
Abstract

Nowadays, many strategies have been developed to design biomaterials to accelerate bacteria-infected wound healing. Here, we presented a new type of multicargo-loaded inverse opal hydrogel microparticle (IOHM) for regulating oxidative stress, antibiosis, and angiogenesis of the bacteria-infected wound. The methacrylate acylated gelatin (GelMA)-based inverse opal hydrogel microparticles (IOHMs) were obtained by using the colloidal crystal microparticles as templates, and fullerol, silver nanoparticles (Ag NPs), and vascular endothelial growth factor (VEGF) were loaded in IOHMs. The developed multicargo-loaded IOHMs displayed good size distribution and biocompatibility, and when they were applied in Cell Culture, bacteria culture, and animal experiments, they exhibited excellent anti-oxidative stress properties, Antibacterial properties, and angiogenesis. These characteristics of the developed multicargo-loaded IOHMs make them ideal for bacteria-infected wound healing.

Keywords

Antibacterial effect; Fullerol; Inverse opal; Reactive oxygen species; Wound healing.

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