2. Academic Validation
  3. Multiple RONS-Loaded Plasma-Activated Ice Microneedle Patches for Transdermal Treatment of Psoriasis

Multiple RONS-Loaded Plasma-Activated Ice Microneedle Patches for Transdermal Treatment of Psoriasis

  • ACS Appl Mater Interfaces. 2024 Sep 4;16(35):46123-46132. doi: 10.1021/acsami.4c10067.
Tong Wu 1,  Jishen Zhang 1,  Xixi Jing 1,  Zewei Wang 2,  Zijin Wu 2,  Hao Zhang 1 2 3,  Dingxin Liu 1 3,  Mingzhe Rong 1,  Paul K Chu 4
Affiliations

Affiliations

  • 1 State Key Laboratory of Electrical Insulation and Power Equipment, Centre for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, P. R. China.
  • 2 Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, P. R. China.
  • 3 Interdisciplinary Research Center of Frontier Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, P. R. China.
  • 4 Department of Physics, Department of Materials Science and Engineering, and Department of Biomedical Engineering, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong 999077, P. R. China.
PMID: 39180585 DOI: 10.1021/acsami.4c10067
Abstract

Cold atmospheric plasma (CAP) is a fledgling therapeutic technique for psoriasis treatment with noninvasiveness, but clinical adoption has been stifled by the insufficient production and delivery of plasma-generated reactive oxygen and nitrogen species (RONS). Herein, patches of air-discharge plasma-activated ice microneedles (PA-IMNs) loaded with multiple RONS are designed for local transdermal delivery to treat psoriasis as an alternative to direct CAP irradiation treatment. By mixing two RONS generated by the air-discharge plasma in the NOx mode and O3 mode, abundant high-valence RONS are produced and incorporated into PA-IMNs via complex gas-gas and gas-liquid reactions. The PA-IMNs abrogate keratinocyte overproliferation by inducing Reactive Oxygen Species (ROS)-mediated loss of the mitochondrial membrane potential and Apoptosis of keratinocytes. The in vivo transdermal treatment confirms that PA-IMNs produce significant anti-inflammatory and therapeutic actions for imiquimod (IMQ)-induced psoriasis-like dermatitis in mice by inhibiting the release of associated inflammatory factors while showing no evident systemic toxicity. Therefore, PA-IMNs have a large potential in transdermal delivery platforms as they overcome the limitations of using CAP directly in the clinical treatment of psoriasis.

Keywords

cold atmospheric plasma; plasma-activated ice microneedles; psoriasis; reactive oxygen and nitrogen species; transdermal delivery.

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