2. Academic Validation
  3. Gilvocarcins, new antitumor antibiotics. 1. Taxonomy, fermentation, isolation and biological activities

Gilvocarcins, new antitumor antibiotics. 1. Taxonomy, fermentation, isolation and biological activities

  • J Antibiot (Tokyo). 1981 Mar;34(3):266-70. doi: 10.7164/antibiotics.34.266.
H Nakano,  Y Matsuda,  K Ito,  S Ohkubo,  M Morimoto,  F Tomita
PMID: 7275807 DOI: 10.7164/antibiotics.34.266
Abstract

Gilvocarcin V and gilvocarcin M, a group of antitumor Antibiotics with a novel skeleton, were discovered in culture broths of Actinomycete DO-38. The producing organism, subsequently determined to be a new species and named Streptomyces gilvotanareus (NRRL 11382). Gilvocarcin V and M were isolated by ethyl acetate extraction and chromatography on silica gel. The Antibiotics are active against Gram-positive bacteria and experimental tumors such as mouse sarcoma 180 and mouse leukemia P388.

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