2. Academic Validation
  3. Studies on beta-lactam antibiotics. III. Synthesis and enzymatic stability of 3-acyloxymethyl-7 beta-[(Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetamido]-3-cephem-4-carboxylic acids

Studies on beta-lactam antibiotics. III. Synthesis and enzymatic stability of 3-acyloxymethyl-7 beta-[(Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetamido]-3-cephem-4-carboxylic acids

  • J Antibiot (Tokyo). 1981 Oct;34(10):1300-10. doi: 10.7164/antibiotics.34.1300.
T Takaya,  H Takasugi,  T Murakawa,  H Nakano
PMID: 7309624 DOI: 10.7164/antibiotics.34.1300
Abstract

3-Acyloxymethyl-7 beta-[(Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino) acetamido]-3-cephem-4-carboxylic acids (7) were synthesized. The stability of 7 to enzymatic hydrolysis and their antimicrobial activity were evaluated. 7 showed good antimicrobial activity against a wide range of Microorganisms. Cephems (7b and 7c) with sterically more hindered acyl groups such as t-butyl and cyclohexyl were most resistant to enzymatic hydrolysis.

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