2. Academic Validation
  3. WWamide-1, -2 and -3: novel neuromodulatory peptides isolated from ganglia of the African giant snail, Achatina fulica

WWamide-1, -2 and -3: novel neuromodulatory peptides isolated from ganglia of the African giant snail, Achatina fulica

  • FEBS Lett. 1993 May 24;323(1-2):104-8. doi: 10.1016/0014-5793(93)81458-c.
H Minakata 1,  T Ikeda,  Y Muneoka,  M Kobayashi,  K Nomoto
Affiliations

Affiliation

  • 1 Suntory Institute for Bioorganic Research, Osaka, Japan.
PMID: 8495720 DOI: 10.1016/0014-5793(93)81458-c
Abstract

Three novel neuropeptides, isolated from ganglia of the African giant snail, Achatina fulica, were named WWamide-1, -2 and -3. These substances were biologically active heptapeptide amides with a Trp residue at both the N- and C-termini. WWamide-1, which displayed an inhibitory activity on a central neuron of the snail, exhibited peripherally modulatory effects on muscular contractions of not only the gut and other tissues of the snail but also certain tissues of other molluscs.

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