2. Academic Validation
  3. GERI-BP002-A, novel inhibitor of acyl-CoA: cholesterol acyltransferase produced by Aspergillus fumigatus F93

GERI-BP002-A, novel inhibitor of acyl-CoA: cholesterol acyltransferase produced by Aspergillus fumigatus F93

  • J Antibiot (Tokyo). 1996 Jan;49(1):31-6. doi: 10.7164/antibiotics.49.31.
Y K Kim 1,  H W Lee,  K H Son,  B M Kwon,  T S Jeong,  D H Lee,  J Shin,  Y Seo,  S U Kim,  S H Bok
Affiliations

Affiliation

  • 1 Bioproducts Research Group, Korea Research Institute of Bioscience & Biotechnology, KIST, Yusung , Korea.
PMID: 8609082 DOI: 10.7164/antibiotics.49.31
Abstract

A new inhibitor of acyl-CoA:cholesterol Acyltransferase (ACAT), designated GERI-BP002-A, was isolated from the culture broth of Aspergillus fumigatus F93 by acetone extraction, EtOAc extraction, SiO2 column chromatography and reverse phase HPLC. Spectroscopic analyses of the compound identified bis (2-hydroxy-3-tert-butyl-5-methylphenyl) methane as the structure and its molecular weight and formula to be 340 and C23H32O2, respectively. GERI-BP002-A inhibited ACAT activity by 50% at the concentration of 50 microM in an Enzyme assay system using rat liver microsomes.

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