2. Metabolic Enzyme/Protease
  3. Lactate Dehydrogenase
  4. MEDS433

MEDS433 是人二氢乳清酸脱氢酶 (hDHODH) 的有效抑制剂，IC50 为 1.2 nM。MEDS433 在纳摩尔范围内对 RSV-A 和 RSV-B 发挥有效的抗病毒活性。MEDS433 诱导干扰素刺激基因编码的抗病毒蛋白表达，能够减少 RSV 复制。

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MEDS433 Chemical Structure

MEDS433 Chemical Structure

CAS No. : 2241027-61-0

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MEDS433 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MEDS433 is a potent inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an IC50 of 1.2 nM. MEDS433 exerts a potent antiviral activity against RSV-A and RSV-B in the one-digit nanomolar range. MEDS433 induces the expression of antiviral proteins encoded by interferon stimulated genes (ISGs) able to reduce RSV replication[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Jurkat IC50
0.75 μM
Compound: 4
Antiproliferative activity against human Jurkat T cells assessed as DNA content after 72 hrs by Hoechst 33258 dye-based fluorescence assay
Antiproliferative activity against human Jurkat T cells assessed as DNA content after 72 hrs by Hoechst 33258 dye-based fluorescence assay
[PMID: 29939742]
Jurkat IC50
68.69 μM
Compound: 4
Antiproliferative activity against human Jurkat T cells assessed as DNA content after 72 hrs in presence of exogenous uridine by Hoechst 33258 dye-based fluorescence assay
Antiproliferative activity against human Jurkat T cells assessed as DNA content after 72 hrs in presence of exogenous uridine by Hoechst 33258 dye-based fluorescence assay
[PMID: 29939742]
PBMC IC50
0.78 μM
Compound: 4
Immunosuppressive activity against human PBMC assessed as inhibition of PHA-stimulated cell proliferation preincubated for 2 hrs followed by PHA stimulation for 72 hrs by Hoechst 33258 dye-based fluorescence assay
Immunosuppressive activity against human PBMC assessed as inhibition of PHA-stimulated cell proliferation preincubated for 2 hrs followed by PHA stimulation for 72 hrs by Hoechst 33258 dye-based fluorescence assay
[PMID: 29939742]
PBMC IC50
57.15 μM
Compound: 4
Immunosuppressive activity against human PBMC assessed as inhibition of PHA-stimulated cell proliferation preincubated for 2 hrs followed by PHA stimulation for 72 hrs in presence of exogenous uridine by Hoechst 33258 dye-based fluorescence assay
Immunosuppressive activity against human PBMC assessed as inhibition of PHA-stimulated cell proliferation preincubated for 2 hrs followed by PHA stimulation for 72 hrs in presence of exogenous uridine by Hoechst 33258 dye-based fluorescence assay
[PMID: 29939742]
THP-1 EC50
0.0397 μM
Compound: 1
Induction of cell differentiation in human THP-1 cells assessed as CD14 expression after 3 days by flow cytometric analysis
Induction of cell differentiation in human THP-1 cells assessed as CD14 expression after 3 days by flow cytometric analysis
[PMID: 33844533]
THP-1 EC50
0.0723 μM
Compound: 1
Induction of apoptosis in human THP-1 cells after 3 days by Annexin-V-FITC staining based flow cytometry
Induction of apoptosis in human THP-1 cells after 3 days by Annexin-V-FITC staining based flow cytometry
[PMID: 33844533]
THP-1 EC50
40 nM
Compound: MEDS433
Induction of cell differentiation in human THP-1 cells measured for 2 days by flow cytometric analysis
Induction of cell differentiation in human THP-1 cells measured for 2 days by flow cytometric analysis
[PMID: 36162075]
THP-1 EC50
72 nM
Compound: MEDS433
Induction of apoptosis in human THP-1 cells measured after 3 days by Annexin-V-FITC staining based FACS analysis
Induction of apoptosis in human THP-1 cells measured after 3 days by Annexin-V-FITC staining based FACS analysis
[PMID: 36162075]
U-937 EC50
0.026 μM
Compound: 1
Induction of cell differentiation in human U-937 cells assessed as CD11b expression after 3 days by flow cytometric analysis
Induction of cell differentiation in human U-937 cells assessed as CD11b expression after 3 days by flow cytometric analysis
[PMID: 33844533]
U-937 EC50
0.0404 μM
Compound: 1
Induction of apoptosis in human U-937 cells after 3 days by Annexin-V-FITC staining based flow cytometry
Induction of apoptosis in human U-937 cells after 3 days by Annexin-V-FITC staining based flow cytometry
[PMID: 33844533]
U-937 EC50
26 nM
Compound: MEDS433
Induction of cell differentiation in human U-937 cells measured for 2 days by flow cytometric analysis
Induction of cell differentiation in human U-937 cells measured for 2 days by flow cytometric analysis
[PMID: 36162075]
U-937 EC50
40 nM
Compound: MEDS433
Induction of apoptosis in human U-937 cells measured after 3 days by Annexin-V-FITC staining based FACS analysis
Induction of apoptosis in human U-937 cells measured after 3 days by Annexin-V-FITC staining based FACS analysis
[PMID: 36162075]
分子量

401.31

Formula

C20H11F4N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MEDS433 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MEDS4332241027-61-0MEDS 433MEDS-433Lactate DehydrogenaseLDHdihydroorotate dehydrogenasehDHODHantiviralRSV-ARSV-BInterferon Stimulated GenesRSV replicationInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-156442
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