2. GPCR/G Protein Neuronal Signaling Apoptosis
  3. Adrenergic Receptor Apoptosis
  4. Metoprolol tartrate

Metoprolol tartrate  (Synonyms: 酒石酸美托洛尔)

目录号: HY-17503B 纯度: 99.98%
COA 产品使用指南

摩尔计算器

Metoprolol tartrate 是一种具有口服活性的、选择性的 β1-肾上腺素受体 (β1-adrenoceptor) 拮抗剂。Metoprolol tartrate 具有抗炎、抗肿瘤和抗血管生成的特性。

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Metoprolol tartrate Chemical Structure

Metoprolol tartrate Chemical Structure

CAS No. : 56392-17-7

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规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ￥253
In-stock
5 mg ￥230
In-stock
10 mg ￥368
In-stock
25 mg ￥700
In-stock
50 mg ￥1250
In-stock
100 mg ￥2200
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Other Forms of Metoprolol tartrate:

Metoprolol tartrate 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Metoprolol tartrate is an orally active, selective β1-adrenoceptor antagonist. Metoprolol tartrate shows anti-inflammation, antitumor and anti-angiogenic properties[1][2][3].

IC50 & Target

β1 adrenoceptor

 

体外研究
(In Vitro)

Metoprolol (0-1000 μg/mL; 24-72 h) shows cytotoxic effect on U937 and MOLT-4 cells dose and time dependently[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Metoprolol tartrate 相关抗体:

Cell Cytotoxicity Assay[3]

Cell Line: U937 and MOLT-4 cells
Concentration: 1, 10, 50, 100, 500 and 1000 μg/mL
Incubation Time: 24, 48 and 72 h
Result: Significantly decreased the viability of U937 and MOLT-4 cells at 1000 μg/mL (3740.14µM) concentration after 48 hours incubation time, significantly reduced the viability of U937 cells at ≥500 μg/ml (≥1870.07µM) concentrations after 72 hours incubation time, and significantly decreased the viability of MOLT4 cells at ≥100 μg/ml (≥374.01µM) concentrations after 72 hours incubation.
体内研究
(In Vivo)

Metoprolol (2.5 mg/kg/h; infusion; 11 weeks) reduces proinflammatory cytokines and atherosclerosis in ApoE−/− Mice[1].
Metoprolol (15 mg/kg/q12h; i.g.; 5 days) shows anti-inflammation and anti-virus effects in murine model with coxsackievirus B3-induced viral myocarditis[2].
Metoprolol (2.5 mg/kg; i.v.; 3 bolus injections) significantly decreased activated caspase-9 protein expression and inhibits myocardial apoptosis in coronary microembolization (CME) rats[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ApoE−/− mice[1]
Dosage: 2.5 mg/kg/h
Administration: Via osmotic minipumps, 11 weeks
Result: Significantly reduced atherosclerotic plaque area in thoracic aorta, reduced serum TNFα and the chemokine CXCL1 as well as decreasing the macrophage content in the plaques.
Animal Model: Balb/c mice, coxsackievirus B3 (CVB3) induced viral myocarditis (VMC) model[2]
Dosage: 15 mg/kg/q12h
Administration: Oral gavage, 5 consecutive days
Result: Reduced pathological scores of VMC induced by CVB3 infection, protected the myocardium against viral damage by reducing serum cTn-I levels. Decreased the levels of myocardial pro-inflammatory cytokines and increase the expression of anti-inflammatory cytokine. Significantly decreased myocardial virus titers.
Clinical Trial
分子量

342.41

Formula

C19H31NO9
CAS 号
性状

固体

颜色

White to light yellow

中文名称

酒石酸美托洛尔
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 100 mg/mL (292.05 mM; 超声助溶)

DMSO 中的溶解度 : 70 mg/mL (204.43 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9205 mL 14.6024 mL 29.2048 mL
5 mM 0.5841 mL 2.9205 mL 5.8410 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 99.98%

COA (288 KB) HNMR (254 KB) LCMS (95 KB)

产品使用指南 (1538 KB)
参考文献

Metoprolol tartrate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 2.9205 mL 14.6024 mL 29.2048 mL 73.0119 mL
5 mM 0.5841 mL 2.9205 mL 5.8410 mL 14.6024 mL
10 mM 0.2920 mL 1.4602 mL 2.9205 mL 7.3012 mL
15 mM 0.1947 mL 0.9735 mL 1.9470 mL 4.8675 mL
20 mM 0.1460 mL 0.7301 mL 1.4602 mL 3.6506 mL
25 mM 0.1168 mL 0.5841 mL 1.1682 mL 2.9205 mL
30 mM 0.0973 mL 0.4867 mL 0.9735 mL 2.4337 mL
40 mM 0.0730 mL 0.3651 mL 0.7301 mL 1.8253 mL
50 mM 0.0584 mL 0.2920 mL 0.5841 mL 1.4602 mL
60 mM 0.0487 mL 0.2434 mL 0.4867 mL 1.2169 mL
80 mM 0.0365 mL 0.1825 mL 0.3651 mL 0.9126 mL
100 mM 0.0292 mL 0.1460 mL 0.2920 mL 0.7301 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Metoprolol56392-17-7酒石酸美托洛尔Adrenergic ReceptorApoptosisBeta Receptorhypertensionischaemic heart diseaseanginaanti-inflammationanti-virusprostate cancerbreast cancerInhibitorinhibitorinhibit

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目录号：
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