2. Metabolic Enzyme/Protease
  3. Isocitrate Dehydrogenase (IDH)
  4. mIDH1-IN-1

mIDH1-IN-1 (compound 43) 是一种有效且选择性的 mIDH1 (异柠檬酸脱氢酶 1 突变体)抑制剂，其 IC50 为 961.5 nM。在 HT1080 细胞中，mIDH1-IN-1 能有效抑制细胞内 2-HG (2-hydroxyglutarate) 的产生，其 EC50 为 208.6±8.0 nM。 mIDH1-IN-1 对 IDH1 突变体 U-87 细胞具有显著的抗增殖活性，其 IC50 为 41.8 nM。 mIDH1-IN-1 是一种抗肿瘤剂，可用于 IDH1 突变实体瘤的研究。

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mIDH1-IN-1 Chemical Structure

mIDH1-IN-1 Chemical Structure

CAS No. : 2757155-96-5

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mIDH1-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Isocitrate Dehydrogenase (IDH) 亚型特异性产品:

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IDH1 IDH2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

mIDH1-IN-1 (compound 43) is a potent and selective mIDH1 (mutant isocitrate dehydrogenases 1) inhibitor, with an IC50 of 961.5 nM. mIDH1-IN-1 potently inhibits intracellular 2-HG (2-hydroxyglutarate) production in HT1080 cells, with an EC50 of 208.6 ± 8.0 nM. mIDH1-IN-1 shows a significant anti-proliferation activity on IDH1 mutant-U-87 cells, with an IC50 of 41.8 nM. mIDH1-IN-1 is an antitumor agent, and can be used for IDH1 mutated solid tumors research[1].

IC50 & Target

IC50: 961.5 ± 25.3 nM (IDH1R132H); EC50: 208.6 ± 8.0 nM (2-HG)[1]
分子量

449.50

Formula

C25H27N3O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

mIDH1-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

mIDH1-IN-12757155-96-5Isocitrate Dehydrogenase (IDH)HT1080 cellU-87 cellsMutant IDH12-HGAntitumorUgi reactionInhibitorinhibitorinhibit

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