MitoEbselen-2 chloride  (Synonyms: MitoPeroxidase 2)

MitoEbselen-2 chloride (MitoPeroxidase 2), a mitochondria-targeted mimic of glutathione peroxidase, is a radiation mitigator. MitoEbselen-2 chloride is effective in reducing lipid hydroperoxides, preventing apoptotic cell death^[1].

MitoEbselen-2 chloride (5-20 μM; 30 min) affords ∼50% radioprotection/mitigation of mouse embryonic cells at the concentration of 20 μM^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MitoEbselen-2 chloride (100 μL of 4 mg/mL; i.v.) increases the survival of mice exposed to whole body γ-irradiation^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

656.01

C₃₅H₃₀ClN₂O₂PSe

1638973-78-0

固体

Off-white to light yellow

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

• [1]. Stoyanovsky DA, et, al. Design and Synthesis of a Mitochondria-Targeted Mimic of Glutathione Peroxidase, MitoEbselen-2, as a Radiation Mitigator. ACS Med Chem Lett. 2014 Nov 18;5(12):1304-1307.  [Content Brief]