2. Anti-infection
  3. Bacterial
  4. MtInhA-IN-1

MtInhA-IN-1 是一种选择性，具有口服活性的结核分枝杆菌 NADH 依赖性烯酰基载体蛋白还原酶 (MtInhA) 抑制剂，IC50 为 0.23 μM。MtInhA-IN-1 有效对抗结核分枝杆菌 H37Rv 菌株，MIC 值为 0.4 μM。

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MtInhA-IN-1 Chemical Structure

MtInhA-IN-1 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

MtInhA-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MtInhA-IN-1 is a selective and orally active Mycobacterium tuberculosis NADH-dependent enoyl-acyl carrier protein reductase (MtInhA) inhibitor with an IC50 of 0.23 μM. MtInhA-IN-1 potently against M. tuberculosis H37Rv strain with a MIC value of 0.4 μM[1].

IC50 & Target

IC50: 0.23 μM (Mycobacterium tuberculosis NADH-dependent enoyl-acyl carrier protein reductase (MtInhA))[1]
MIC: 0.4 μM (M. tuberculosis H37Rv strain), 0.1 μM (M. tuberculosis strains PT2), 0.2 μM (M. tuberculosis strains PT12), and 0.1 μM (M. tuberculosis strains PT20)[1]
体外研究
(In Vitro)

MtInhA-IN-1 (compound 19k) 显示出对一组多重耐药结核分枝杆菌菌株、结核分枝杆菌菌株 PT2、PT12 和 PT20 的抑制活性。对 PT2、PT12 和 PT20 的 MIC 值分别为 0.1 μM、0.2 μM 和 0.1 μM。此外，MtInhA-IN-1 对 HepG2 和 Vero 细胞的细胞毒性较低[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MtInhA-IN-1 相关抗体:
体内研究
(In Vivo)

MtInhA-IN-1 (compound 19k; 300-450 μM/kg; p.o; daily; for 14 days）在小鼠结核病模型中表现出抑菌作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: M. tuberculosis-infected mice [1]
Dosage: 300 μM/kg and 450 μM/kg
Administration: Oral administration; daily; for 14 days
Result: Reduced the growth of bacilli in the lungs of mice.
分子量

396.32

Formula

C21H22BrN3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MtInhA-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MtInhA-IN-1BacterialMtInhA inhibitorMycobacterium tuberculosisorally active4-aminoquinolinesInhibitorinhibitorinhibit

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目录号：
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